GlpBio

PPAR

PPAR(过氧化物酶体增殖剂激活受体)

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

PPAR 相关产品(215)

  • GC47819 structure
    GC47819Oleoyl Ethanolamide-d2
    CAS: 1245477-09-1
    纯度: >99.00%

    An internal standard for the quantification of oleoyl ethanolamide

  • GC47820 structure
    GC47820Oleoyl Ethanolamide-d4
    CAS: 946524-36-3
    纯度: >99.00%

    An internal standard for the quantification of oleoyl ethanolamide

  • GC47866 structure
    GC47866Palmitoyl Ethanolamide-d5
    CAS: 2117730-91-1
    纯度: >99.00%

    A neuropeptide with diverse biological activities

  • GC48059 structure
    GC48059Rosiglitazone-d3
    CAS: 1132641-22-5
    纯度: >99.00%

    An internal standard for the quantification of rosiglitazone

  • GC48272 structure
    GC48272ZLY032
    CAS: 2314465-67-1
    纯度: >98.00%

    A dual FFAR1 and PPARδ agonist

  • GC48426 structure
    GC48426CAY10771
    CAS: 2522599-79-5
    纯度: >98.00%

    A dual agonist of FXR and PPARδ

  • GC48521 structure
    GC48521KRP 297
    CAS: 213252-19-8
    纯度: >98.00%

    A dual agonist of PPARα and PPARγ

  • GC48782 structure
    GC4878210,13-epoxy-11-methyl-Octadecadienoic Acid
    CAS: 57818-39-0
    纯度: >95.00%

    A furan fatty acid

  • GC49087 structure
    GC49087Clofibric Acid-d4
    CAS: 1184991-14-7
    纯度: >99.00%

    An internal standard for the quantification of clofibric acid

  • GC49521 structure
    GC49521MHY553
    CAS: 6265-56-1
    纯度: >98.00%

    An agonist of PPARα

  • GC49884 structure
    GC49884Trigonelline-d3 (chloride)
    纯度: >99.00%

    An internal standard for the quantification of trigonelline

  • GC50019 structure
    GC50019GW 1929 hydrochloride
    CAS: 1217466-21-1

    A non-thiazolidinedione activator of PPARγ

  • GC60675 structure
    GC60675Caulophyllogenin
    CAS: 52936-64-8

    Caulophyllogenin是一种从M.polimorpha中提取的三萜皂苷。Caulophyllogenin是PPARγ的部分激动剂，EC50值为12.6μM。Caulophyllogenin可用于研究2型糖尿病，肥胖症，代谢综合征和炎症。

  • GC60710 structure
    GC60710Ciprofibrate impurity A
    CAS: 1474058-89-3

    CiprofibrateimpurityA是Ciprofibrate的一种杂质。Ciprofibrate是一种PPARα激动剂。

  • GC61043 structure
    GC61043Mesalamine impurity P
    CAS: 887256-40-8

    MesalamineimpurityP是Mesalamine的杂质。5-Aminosalicylicacid(Mesalamine)是一种特异性的 PPARγ 激动剂，还抑制p21-激活激酶1(PAK1)和 NF-κB。

  • GC61055 structure
    GC61055Methyl oleanonate
    CAS: 1721-58-0
    纯度: >99.00%

    Methyloleanonate是从Pistacia中分离得到的三萜类PPARγ激动剂。Methyloleanonate是齐墩果酸衍生物，具有抗癌作用。

  • GC61187 structure
    GC61187Pioglitazone D4
    CAS: 1134163-29-3

    An internal standard for the quantification of pioglitazone

  • GC61805 structure
    GC61805Cefminox sodium
    CAS: 75498-96-3
    纯度: >98.00%

    Cefminox Sodium (Meicelin, MT-141) is the sodium salt form of cefminox, a semi-synthetic, second-generation, beta-lactamase-stable cephalosporin with antibacterial activity.

  • GC62203 structure
    GC62203Falcarindiol
    CAS: 55297-87-5
    纯度: >99.00% / >98.00%

    Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.

  • GC62836 structure
    GC62836AMG131
    CAS: 315224-26-1
    纯度: >99.00%

    AMG131 (INT131) 是一种有效且高度选择性的 PPARγ 部分激动剂，可与 PPARγ 结合，取代罗格列酮，Ki 为~10 nM。 AMG131 可用于研究 2 型糖尿病 (T2DM)。

  • GC62974 structure
    GC62974FK614
    CAS: 193012-35-0
    纯度: >99.50%

    FK614 是一种具有口服活性，有效的，选择性的 PPARγ 调制剂 (SPPARM)。FK614 对脂肪细胞分化各阶段 PPARγ 的激活有不同的影响。FK614 是一种非噻唑烷二酮类胰岛素增敏剂。FK614 可用于高血糖、高甘油三酯、葡萄糖耐受不良和 2 型糖尿病的研究。

  • GC63358 structure
    GC633585-Aminosalicylic Acid-D3 hydrochloride
    CAS: 1346601-18-0

    5-Aminosalicylic Acid-D3 (Mesalamine-D3) hydrochloride 是 5-Aminosalicylic Acid hydrochloride 的氘代物。5-Aminosalicylic acid (Mesalamine) hydrochloride 是一种特异性的 PPARγ 激动剂，还抑制 p21-激活激酶1 (PAK1) 和 NF-κB。

  • GC64099 structure
    GC64099AZD-9574
    CAS: 2756333-39-6

    AZD-9574是一种新型的、具有血脑屏障通透性的PARP1抑制剂，AZD-9574在SSB位点选择性抑制PARP1。

  • GC64699 structure
    GC64699Bocidelpar
    CAS: 2095128-20-2
    纯度: >98.00%

    Bocidelpar 是过氧化物酶体增殖物激活受体 delta (PPAR-δ) 的调节剂。Bocidelpar 可改善杜兴肌营养不良 (DMD) 肌肉细胞中的线粒体生物合成和功能 (信息提取自专利 WO2017062468A1，compound 2b)。