GW 1929 hydrochloride

目录号: GC50019纯度: >98%
A non-thiazolidinedione activator of PPARγ

GW 1929 hydrochloride
Cas No.: 1217466-21-1
规格价格库存数量操作
5mg¥961.00现货
1
10mg¥1,668.00现货
1
25mg¥3,590.00现货
1
50mg¥6,169.00现货
1
10mM (in 1mL DMSO)¥1,056.00现货
1

文献被引

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产品描述 Description

Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.

Brown et al (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48 1415 PMID:10389847 |Nugent et al (2001) Potentiation of glucose uptake in 3T3-L1 adipocytes by PPARγ agonists is maintained in cells expressing a PPARγ dominant-negative mutant: evidence for selectivity in the downstream responses to PPARγ activation. Mol.Endocrinol. 15 1729 PMID:11579205 |Way et al (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists. J.Biol.Chem. 276 25651 PMID:11373275

产品文档 Product Documents

化学性质Chemical Properties

CAS 号
1217466-21-1
SMILES
Cl.CN(CCOC1=CC=C(C[C@H](NC2=CC=CC=C2C(=O)C2=CC=CC=C2)C(O)=O)C=C1)C1=NC=CC=C1
分子式
C30H29N3O4.HCl
分子量
532.03 g/mol
溶解性
Soluble in DMSO
保存条件
Store at -20&#176;C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至 37°C,然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备 RT,或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol