Fascaplysin is an inhibitor of cyclin D kinase 4/ cyclin D1 (IC50 = 0.35 μM) that was originally isolated from the marine sponge Thorectandra. It is significantly less selective for Cdk6/cyclin D1 (IC50 = 3.4 μM) and does not inhibit other Cdks and tyrosine kinases. Fascaplysin is reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest. Inhibition of Cdk4 via fascaplysin has been shown to induce peroxisome-proliferator-activated receptor γ-1α deacetylation (IC50 = 0.7 uM) and has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism.
Fascaplysin (chloride)
目录号: GC18693纯度: >95.00%同义词: NSC 622398
A selective Cdk4 inhibitor
Cas No.: 114719-57-2
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 1mg | ¥755.00 | 现货 | 1 | |
| 5mg | ¥2,983.00 | 现货 | 1 |
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Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
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产品描述 Description
产品文档 Product Documents
Purity:>95.00%
化学性质Chemical Properties
CAS 号
114719-57-2
同义词
NSC 622398
化学名
12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium, monochloride
SMILES
O=C1C2=[N+](C=CC3=C2C4=C(C=CC=C4)N3[H])C5=CC=CC=C51.[Cl-]
分子式
C18H11N2O.Cl
分子量
306.8 g/mol
溶解性
DMF: 0.14 mg/mL,DMSO: 16 mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
保存条件
Store at -20°C; protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。
计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度
g/mol