Prostaglandin DM (PGDM)-d4 contains four deuterium atoms at the 18, 18', 19 and 19' positions. It is intended for use as an internal standard for the quantification of PGDM by GC- or LC-mass spectrometry. PGD2 plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.1 PGDM is a major urinary metabolite of PGD2 with a unique lower sidechain that readily undergoes reversible cyclization.2 It is used as a biomarker to assess endogenous production of PGD2.
1.Giles, H., and Leff, P.The biology and pharmacology of PGD2Prostaglandins35(2)277-300(1988)
2.Morrow, J.D., Prakash, C., Awad, J.A., et al.Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assayAnal. Biochem.193(1)142-148(1991)
