GlpBio

NN1177 (trifluoroacetate salt)

目录号: GC92131纯度: >98.00%
NN1177 (trifluoroacetate salt)是胰高血糖素受体（GCGR）和胰高血糖激素样肽1受体（GLP-1R）的双肽激动剂。
NN1177 (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥1,386.00现货
1
5 mg¥5,544.00现货
1
10 mg¥9,702.00现货
1
25 mg¥13,860.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

NN1177 is a dual peptide agonist of the glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R).1 It induces cAMP production in BHK-21 cells expressing human GCGR or GLP-1R (EC50s = 1.83 and 0.92 pM, respectively). In vivo, NN1177 (3-5 nmol/kg) reduces body weight and cumulative food intake in a mouse model of diet-induced obesity. It also reduces body weight, hepatic fat accumulation and fibrosis, and plasma alanine transaminase (ALT) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-fat, high-fructose, and high-cholesterol diet.2

References:
[1]. Simonsen, L., Lau, J., Kruse, T., et al.Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfallsPLoS One17(3)e0264974(2022).
[2]. Monfeuga, T., Norlin, J., Bugge, A., et al.Evaluation of long acting GLP1R/GCGR agonist in a DIO and biopsy-confirmed mouse model of NASH suggest a beneficial role of GLP-1/glucagon agonism in NASH patientsMol. Metab.79101850(2024).

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

SMILES
NC([C@@]([C@H](O)C)([H])NC([C@H](CCCCNC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CC[C@H](NC(CC[C@H](NC(CCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)C(O)=O)=O)CO)=O)CCC(O)=O)=O)CO)=O)=O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@@]([C@H](O)C)([H])NC([C@@H](NC([C@@]([C@H](O)C)([H])NC(CNC([C@H](CCC(N)=O)NC(C(C)(C)NC([C@@H](N)CC1=CN=CN1)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)CC(C=C3)=CC=C3O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)=O)=O)=O)=O.FC(F)(F)C(O)=O
分子式
C206H323N51O66 ? XCF3COOH
分子量
4570.1 g/mol
溶解性
Acetonitrile: Slightly soluble: 0.1-1 mg/ml,DMSO: Sparingly soluble: 1-10 mg/ml,Water: Slightly soluble: 0.1-1 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol