GlpBio

PPAR

PPAR(过氧化物酶体增殖剂激活受体)

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

PPAR 相关产品(215)

  • GC16944 structure
    GC16944SR 1664
    CAS: 1338259-05-4

    An inhibitor of Cdk5-mediated PPARγ phosphorylation

  • GC17135 structure
    GC17135Ciglitazone
    CAS: 74772-77-3

    A potent, selective PPARγ ligand

  • GC17824 structure
    GC17824GSK 0660
    CAS: 1014691-61-2
    纯度: >98.00%

    GSK 0660是一种强效的PPARβ拮抗剂，IC 50 值为155nM。

  • GC18024 structure
    GC18024GW 7647
    CAS: 265129-71-3
    纯度: >98.00% / >99.00%

    A selective PPARα agonist

  • GC18037 structure
    GC18037Tesaglitazar
    CAS: 251565-85-2
    纯度: >98.00%

    A PPARα/γ agonist

  • GC18147 structure
    GC18147Tretinoin (Aberela)
    CAS: 302-79-4
    纯度: >99.50% / >98.00%

    Tretinoin (Aberela) 是一种维生素 A 衍生的非肽类亲脂性小分子，可作为核 RA 受体 (RAR) 的配体，将其从转录抑制因子转化为激活因子 .在培养的人系膜细胞中，维甲酸 (Aberela) 以剂量和时间依赖性方式增加还原型谷胱甘肽含量和过氧化氢酶活性，从而阻止 H2O2 的细胞毒性。

  • GC18876 structure
    GC18876CAY10599
    CAS: 1143573-33-4

    An agonist of PPARγ

  • GC19242 structure
    GC19242Seladelpar
    CAS: 851528-79-5
    纯度: >98.00% / >98.50%

    Seladelpar (MBX-8025) 是一种口服有效的（50% 作用浓度 EC50 2 nM）和特异性 PPAR-δ 激动剂。

  • GC19280 structure
    GC19280Pemafibrate
    CAS: 848259-27-8

    Pemafibrate (K-877) 是一种口服过氧化物酶体增殖物激活受体 (PPAR)-α 激动剂，用于治疗高脂血症，对 Gal4hPPARα 的 EC50 = 1 nM 。

  • GC19450 structure
    GC19450MA-0204
    CAS: 2095128-17-7
    纯度: >99.50%

    MA-0204 是一种有效的、高选择性和可口服的过氧化物酶体增殖物激活受体 δ (PPARδ) 调节剂，对人类、小鼠和大鼠 PPARδ 的 EC50 分别为 0.4 nM、7.9 nM 和 10 nM。

  • GC19504 structure
    GC19504LJ570
    CAS: 2252488-69-8

    LJ570 是一种 PPARα/PPARγ 双重激动剂，EC50 分别为 1.05 和 0.12 μM。

  • GC30379 structure
    GC30379Saroglitazar
    CAS: 495399-09-2
    纯度: >98.00%

    A PPARα and PPARγ dual agonist

  • GC30462 structure
    GC30462Pparδ agonist 1
    CAS: 1902161-12-9

    Pparδagonist1是PPAR-δ的激动剂，EC50值为5.06nM，可用于研究与PPAR-δ相关的疾病，例如:线粒体疾病、肌肉疾病、血管疾病、脱髓鞘疾病和代谢疾病。

  • GC31325 structure
    GC31325Saroglitazar Magnesium
    CAS: 1639792-20-3
    纯度: >98.50%

    Saroglitazarmagnesium是一种新型的过氧化物酶体增殖物活化受体PPAR的激动剂，具有显著PPARα活性和中度PPARγ活性,在HepG2细胞中的EC50值分别为0.65pMand3nM。

  • GC31350 structure
    GC31350Astaxanthin
    CAS: 472-61-7
    纯度: >98.00%

    Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.

  • GC31396 structure
    GC31396Raspberry ketone (Frambione)
    CAS: 5471-51-2
    纯度: >99.50%

    Raspberry ketone (p-Hydroxybenzyl acetone, Frambinone, Oxyphenylon, Rheosmin, Rasketone) is a natural phenolic compound that is the primary aroma compound of red raspberries. Raspberry ketone shows cardioprotective action against isoproterenol-induced myocardial infarction in rats, and the effects may be due to its PPAR-α agonistic activity.

  • GC31408 structure
    GC31408Indeglitazar (PPM 204)
    CAS: 835619-41-5
    纯度: >99.50%

    Indeglitazar (PPM 204) (PPM 204) 是一种可口服的 PPAR 泛激动剂，适用于所有三种 PPARα, PPARδ和PPARγ；。

  • GC31450 structure
    GC31450Naveglitazar racemate
    CAS: 916085-47-7

    Naveglitazarracemate是Naveglitazar的外消旋体。Naveglitazar是过氧化物酶体增殖物激活受体(PPAR)α-γ双重，γ显性激动剂，在动物模型具有降低葡萄糖潜力。

  • GC31451 structure
    GC31451Peliglitazar racemate (BMS 426707-01 racemate)
    CAS: 331744-72-0

    Peliglitazar 外消旋体（BMS 426707-01 外消旋体）是 Peliglitazar 的外消旋体。

  • GC31452 structure
    GC31452AVE-8134
    CAS: 304025-09-0

    AVE-8134是PPARα的有效激动剂，对人体和啮齿类动物的PPARα的EC50值分别为100和3000nM。

  • GC31462 structure
    GC31462Arhalofenate (MBX 102)
    CAS: 24136-23-0

    A prodrug form of a PPARγ partial agonist

  • GC31471 structure
    GC31471GSK376501A
    CAS: 1010412-80-2
    纯度: >99.00%

    GSK376501A是一种选择性的过氧化物酶体增殖物激活受体γ(PPARγ)调节剂。可用于治疗2型糖尿病。

  • GC31497 structure
    GC31497KD-3010
    CAS: 934760-92-6

    KD3010是一种具有口服活性的有效的选择性PPARδ激动剂。

  • GC31510 structure
    GC31510Pparδ agonist
    CAS: 942594-93-6

    PPARδagonist是PPARδ的激动剂，来自专利US20180071304，化合物实例10。