PPAR
PPAR(过氧化物酶体增殖剂激活受体)
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
PPAR 相关产品(215)
- GC13639Inolitazone dihydrochlorideCAS: 223132-38-5纯度: >98.00%
Inolitazone dihydrochloride (Efatutazone dihydrochloride) 是一种新型的高亲和力 PPARγ 激动剂，其生物活性依赖于 PPARγ，抑制生长的 IC50 为 0.8 nM。
- GC1396015-deoxy-Δ-12,14-Prostaglandin J2CAS: 87893-55-8纯度: >95.00%
Contains 90-95% of the trans,trans-Δ 12,14 isomer
- GC14584Fenofibric acidCAS: 42017-89-0纯度: >99.50%
An agonist of PPARα, PPARγ, and PPARδ and an active metabolite of fenofibrate
- GC16607MesalamineCAS: 89-57-6纯度: >98.00%
An NSAID and active metabolite of sulfasalazine, balsalazide, and olsalazine
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC12134 | FH535 | 108409-83-2 | >99.50% | |
An inhibitor of β-catenin signaling | ||||
| GC12252 | S26948 | 353280-43-0 | - | |
A PPARγ agonist | ||||
| GC12289 | 3-Thiatetradecanoic Acid | 116296-31-2 | - | |
An analog of myristic acid | ||||
| GC12400 | N-Octadecyl-N'-propyl-sulfamide | 925891-74-3 | - | |
A potent PPARα activator | ||||
| GC12760 | LT175 | 862901-87-9 | - | |
A dual PPARα/γ ligand | ||||
| GC13639 | Inolitazone dihydrochloride | 223132-38-5 | >98.00% | |
Inolitazone dihydrochloride (Efatutazone dihydrochloride) 是一种新型的高亲和力 PPARγ 激动剂，其生物活性依赖于 PPARγ，抑制生长的 IC50 为 0.8 nM。 | ||||
| GC13829 | BADGE | 1675-54-3 | >85.00% | |
A PPARγ ligand that disrupts hormone-mediated cell differentiation | ||||
| GC13960 | 15-deoxy-Δ-12,14-Prostaglandin J2 | 87893-55-8 | >95.00% | |
Contains 90-95% of the trans,trans-Δ 12,14 isomer | ||||
| GC14187 | GW 6471 | 880635-03-0 | >98.50% / >98.00% | |
GW 6471 是一种有效的双重 PPARα/γ 拮抗剂，其具有体内外抗增殖活性。GW 6471与 PPARα 和 PPARγ 的结合亲和力的IC 50 值分别为95.3 ± 42.0 nM 和39.4 ± 18.2 nM。GW 6471可用于癌症的研究。 | ||||
| GC14232 | SR 1824 | 1338259-06-5 | - | |
A non-agonist PPARγ ligand | ||||
| GC14246 | Muraglitazar | 331741-94-7 | - | |
A PPARα and PPARγ dual agonist | ||||
| GC14531 | Glycerophospho-N-Oleoyl Ethanolamine | 201738-24-1 | - | |
Precursor of oleoyl ethanolamide | ||||
| GC14543 | Bezafibrate | 41859-67-0 | >99.00% | |
A non-selective PPAR agonist | ||||
| GC14584 | Fenofibric acid | 42017-89-0 | >99.50% | |
An agonist of PPARα, PPARγ, and PPARδ and an active metabolite of fenofibrate | ||||
| GC14595 | MCC-555 | 161600-01-7 | - | |
A structural homolog of rosiglitazone | ||||
| GC15085 | G3335 | 36099-95-3 | - | |
A PPARγ antagonist III | ||||
| GC15673 | CP 775146 | 702680-17-9 | - | |
A PPARα agonist | ||||
| GC15909 | RB394 | 1830320-32-5 | - | |
A dual modulator of sEH and PPARγ | ||||
| GC15995 | BMS 687453 | 1000998-59-3 | >99.00% | |
A potent PPARα agonist | ||||
| GC16103 | Oleylethanolamide | 111-58-0 | >90.00% | |
An endogenous, potent agonist for PPARα | ||||
| GC16125 | L-165041 | 79558-09-1 | >99.50% | |
An agonist of PPARβ/δ | ||||
| GC16301 | Cetaben | 55986-43-1 | >99.00% | |
A non-fibrate hypolipidemic drug | ||||
| GC16488 | SR 2595 | 1415252-61-7 | - | |
An inverse agonist of PPARγ | ||||
| GC16607 | Mesalamine | 89-57-6 | >98.00% | |
An NSAID and active metabolite of sulfasalazine, balsalazide, and olsalazine | ||||