GlpBio

IDO

IDO(吲哚胺2,3-双加氧酶)

Indoleamine 2,3-dioxygenase (IDO) is an enzyme catalyzing the oxidative degradation of L-tryptophan in the kynurenine pathway, in which the pyrrole ring of L-tryptophan is cleaved to generate N-formyl-kynurenine. Mature human IDO enzyme is a 45 kDa monomeric protein of 403 amino acids that is encoded by the IDO gene (15 kb with 10 exons). According to X-ray crystallographic analysis, the chemical structure of human IDO enzyme consists of two distinct α-helical domains (one small and one large) and a heme prosthetic group, where the heme is coordinated to the active site by a histidine (His) imidazole as the proximal fifth ligand.

IDO 相关产品(45)

  • GC13912 structure
    GC13912NLG919
    CAS: 1402836-58-1
    纯度: >99.50%

    An IDO pathway inhibitor

  • GC14425 structure
    GC14425IDO inhibitor 1
    CAS: 1204669-37-3

    Indoleamine-2,3-dioxygenase inhibitor

  • GC11008 structure
    GC11008Necrostatin-1
    CAS: 4311-88-0
    纯度: >98.00% / >99.00%

    Necrostatin-1主要作用于细胞中的RIP1，Necrostatin-1是一种RIP1激酶抑制剂，IC50值为0.32 mM。

  • GC11066 structure
    GC11066Indoximod (NLG-8189)
    CAS: 110117-83-4
    纯度: >99.00%

    An inhibitor of indoleamine 2,3-dioxygenase

  • GC13519 structure
    GC13519Navoximod
    CAS: 1402837-78-8
    纯度: >99.00%

    Navoximod (GDC-0919; NLG-919) 是一种有效的 IDO（吲哚胺-(2,3)-双加氧酶）通路抑制剂，Ki/EC50 为 7 nM/75 nM。

  • GC15833 structure
    GC15833Norharmane
    CAS: 244-63-3
    纯度: >98.00%

    A co-mutagenic heterocyclic amine

  • GC15846 structure
    GC15846INCB024360 analogue
    CAS: 914471-09-3
    纯度: >98.00%

    A selective IDO1 inhibitor

  • GC15876 structure
    GC15876IDO-IN-1
    CAS: 914638-30-5
    纯度: >98.00%

    A potent IDO inhibitor

  • GC17968 structure
    GC17968INCB-024360
    CAS: 1204669-58-8
    纯度: >99.50%

    INCB-024360，又名epacadostat，是一种口服小分子选择性IDO1抑制剂（IC 50 = 71.8nM）。

  • GC19079 structure
    GC19079BMS-986205
    CAS: 1923833-60-6
    纯度: >99.50%

    BMS-986205是一种选择性的不可逆的吲哚胺2,3-双加氧酶1（IDO1）的抑制剂，在过表达人IDO1的HEK293细胞中，IC 50 值为1.1μM。

  • GC32879 structure
    GC32879PF-06840003 (EOS200271)
    CAS: 198474-05-4
    纯度: >98.00%

    An inhibitor of IDO-1

  • GC32899 structure
    GC32899IDO-IN-4
    CAS: 1629125-65-0
    纯度: >99.00%

    IDO-IN-4 (IDO-IN-4) 是一种吲哚胺 2,3-双加氧酶 1 (IDO-1) 抑制剂，提取自专利 WO2014150677A1，化合物实施例 1 对映异构体 1。

  • GC33012 structure
    GC33012IDO-IN-2
    CAS: 1668565-74-9
    纯度: >99.50%

    An IDO1 inhibitor

  • GC33058 structure
    GC33058IDO-IN-3
    CAS: 2070018-30-1
    纯度: >99.50%

    An inhibitor of IDO1

  • GC33191 structure
    GC33191IDO-IN-9
    CAS: 1888378-12-8

    IDO-IN-9是一个吲哚胺-2,3-双加氧酶(IDO)抑制剂，在激酶实验和Hela细胞实验中的IC50值分别为0.011和0.0018μM,来自专利WO2016041489A1，化合物6。

  • GC33287 structure
    GC33287LY-3381916
    CAS: 2166616-75-5
    纯度: >98.00%

    An IDO1 inhibitor

  • GC33671 structure
    GC33671GNF-PF-3777 (8-Nitrotryptanthrin)
    CAS: 77603-42-0

    A tryptanthrin derivative with diverse biological activities

  • GC33963 structure
    GC33963IDO-IN-12
    CAS: 1888341-29-4
    纯度: >98.00%

    IDO-IN-12是一个吲哚胺2,3-双加氧酶(IDO)抑制剂，来自专利WO2017181849A1。

  • GC34137 structure
    GC34137IDO-IN-5 (NLG-1489)
    CAS: 1402837-79-9

    IDO-IN-5 (NLG-1489) (NLG-1489) 是一种吲哚胺 2,3-双加氧酶 (IDO) 抑制剂，提取自专利 WO WO2012142237A1，化合物 1489，IC50 为 1-10 μM.

  • GC34139 structure
    GC34139IDO-IN-8 (NLG-1487)
    CAS: 1402837-77-7
    纯度: >99.50%

    IDO-IN-8 (NLG-1487) (NLG-1487) 是一种吲哚胺 2,3-双加氧酶 (IDO) 抑制剂，提取自专利 WO WO2012142237A1，化合物 1487，IC50 为 1-10 μM.

  • GC34149 structure
    GC34149IDO-IN-6 (NLG-1486)
    CAS: 1402837-76-6
    纯度: >99.50%

    IDO-IN-6 (NLG-1486) (NLG-1486) 是一种吲哚胺 2,3-双加氧酶 (IDO) 抑制剂，提取自专利 WO WO2012142237A1，化合物 1486，IC50 <1 μM.

  • GC34621 structure
    GC34621IACS-8968
    CAS: 2144425-14-7
    纯度: >98.00%

    IACS-8968是IDO和TDO的双抑制剂，其pIC50s值分别为6.43，<5。

  • GC34622 structure
    GC34622IACS-8968 R-enantiomer
    CAS: 2239305-67-8
    纯度: >98.00%

    IACS-8968(R-enantiomer)是IACS-8968的R型对映异构体。IACS-8968是IDO和TDO的双抑制剂，其pIC50s值分别为6.43，<5。

  • GC34623 structure
    GC34623IACS-8968 S-enantiomer
    CAS: 2239305-70-3
    纯度: >98.00%

    IACS-8968(S-enantiomer)是IACS-8968的S型对映异构体。IACS-8968是IDO和TDO的双抑制剂，其pIC50s值分别为6.43，<5。