CYP3A/CYP450
CYP3A4 is an enzyme of cytochrome P450 superfamily found in human liver. It catalyzes the metabolism of endogenous and exogenous agents ( e.g. xenobiotics).
CYP3A/CYP450 相关产品(18)
- GC13079VoriconazoleCAS: 137234-62-9纯度: >99.50%
Voriconazole是一种强效竞争性抑制剂，可抑制CYP2B6（IC 50 =1.71μM）、CYP2C9（IC 50 =3.62μM）、CYP2C19（IC 50 =5.25μM）和CYP3A（IC 50 =2.90μM）。
- GC137847-EthoxyresorufinCAS: 5725-91-7纯度: >98.00%
A fluorogenic substrate for, and inhibitor of, CYP1A1
- GC147811-Aminobenzotriazole (ABT)CAS: 1614-12-6纯度: >99.50%
1-Aminobenzotriazole (ABT)是具有口服活性的细胞色素P450（CYP）的非特异性和不可逆抑制剂。
- GC16754ClarithromycinCAS: 81103-11-9纯度: >98.00%
Clarithromycin是一种大环内酯类抗生素，通过抑制细菌蛋白质合成发挥作用，与细菌核糖体的50S亚基结合，阻止肽链延长，从而抑制细菌生长。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC14269 | Cobicistat (GS-9350) | 1004316-88-4 | >98.00% | |
An inhibitor of CYP3A | ||||
| GC10554 | 3-Cyano-7-ethoxycoumarin | 117620-77-6 | >98.00% | |
A fluorogenic CYP450 substrate | ||||
| GC10762 | 4β-hydroxy Cholesterol | 17320-10-4 | >95.00% | |
An oxysterol | ||||
| GC10778 | DDMS | 206052-03-1 | - | |
A potent inhibitor of 20-HETE synthesis | ||||
| GC10886 | Methoxyresorufin | 5725-89-3 | - | |
A fluorogenic CYP1A1/2 substrate | ||||
| GC11731 | 4-phenyl-1,2,3-Thiadiazole | 25445-77-6 | - | |
Selective inhibitor of CYP2B4 and CYP2E1 | ||||
| GC11864 | 6,7-dihydroxy Bergamottin | 145414-76-2 | >98.00% | |
A potent CYP3A4 inhibitor | ||||
| GC13079 | Voriconazole | 137234-62-9 | >99.50% | |
Voriconazole是一种强效竞争性抑制剂，可抑制CYP2B6（IC 50 =1.71μM）、CYP2C9（IC 50 =3.62μM）、CYP2C19（IC 50 =5.25μM）和CYP3A（IC 50 =2.90μM）。 | ||||
| GC13784 | 7-Ethoxyresorufin | 5725-91-7 | >98.00% | |
A fluorogenic substrate for, and inhibitor of, CYP1A1 | ||||
| GC14618 | PPOH | 206052-01-9 | - | |
Selective inhibitor of epoxygenation reactions catalyzed by CYP4A2 and CYP4A3 | ||||
| GC14781 | 1-Aminobenzotriazole (ABT) | 1614-12-6 | >99.50% | |
1-Aminobenzotriazole (ABT)是具有口服活性的细胞色素P450（CYP）的非特异性和不可逆抑制剂。 | ||||
| GC15445 | TMS | 24144-92-1 | >99.00% / >98.00% | |
TMS（2,3',4,5'-tetramethoxystilbene）是一种特异性强效的CYP1B1抑制剂，IC 50 值为6±2nmol/L。 | ||||
| GC16073 | Dronedarone | 141626-36-0 | >99.50% | |
An antiarrhythmic agent | ||||
| GC16550 | Diosmetin | 520-34-3 | >99.50% | |
A flavonoid with diverse biological activities | ||||
| GC16754 | Clarithromycin | 81103-11-9 | >98.00% | |
Clarithromycin是一种大环内酯类抗生素，通过抑制细菌蛋白质合成发挥作用，与细菌核糖体的50S亚基结合，阻止肽链延长，从而抑制细菌生长。 | ||||
| GC16777 | YM 511 | 148869-05-0 | - | |
YM 511 是一种高度特异性的非甾体芳香酶抑制剂。 | ||||
| GC17552 | Pentoxyresorufin | 87687-03-4 | >98.00% | |
A fluorogenic substrate for CYP enzymes | ||||
| GC14382 | VT-464 R enantiomer | - | - | |
CYP17 lyase inhibitor | ||||