Signaling Pathways

Tanzawaic acid B is a fungal metabolite that has been found in Penicillium and has diverse biological activities.

Rosuvastatin EP impurity A is a potential impurity in commercial preparations of the HMG-CoA reductase inhibitor rosuvastatin.

L-742,001 is an inhibitor of influenza virus PA endonuclease (IC50 = 0.5 µM), an essential subdomain of the viral RNA polymerase.

GSK199 analog is an inhibitor of peptidyl arginine deiminase 4 (PAD4) and a derivative of the PAD4 inhibitor GSK199.

(±)2-HOTrE is an oxylipin.

Nedometinib is a MEK1 inhibitor (IC50 = 135 nM).

10-(Phosphonooxy)-1-decanole is a hydrolytic degradation product of 10-methacryloyloxydecyl dihydrogen phosphate-N-methylacryloyl glycine (MDP-NMGly) dental primers.

Pomalidomide 4’-PEG5-amine is a PEGylated form of the cereblon (CRBN) inhibitor pomalidomide .

Clerosterol is a phytosterol that has been found in C. fragile and has diverse biological activities.

Pomalidomide 4'-alkylC6-amine is a building block in the synthesis of proteolysis-targeting chimeras (PROTACs) and a derivative of the cereblon inhibitor pomalidomide .

10α-hydroxy Naltrexone is a derivative of the opioid antagonist naltrexone.

PROTAC RAF degrader 1 is a proteolysis-targeting chimera (PROTAC) that contains the inhibitor of mutant V600E and wild-type B-RAF vemurafenib (PLX4032; ) conjugated to VHL ligand 1 .

DTPD-Q is an oxidized derivative of the antioxidant and methylphenyl substituted p-phenylenediamine DTPD.

CP-4 is a fluorescent probe for mesenchymal stem cells.

LYS-006 is an inhibitor of leukotriene A4 (LTA4) hydrolase.

PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.

GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4).

PFI-6 is a chemical probe for the YEATS domain-containing proteins MLLT1 and MLLT3 (IC50s = 140 and 160 nM, respectively).

Homogentisic acid lactone is a fungal metabolite that has been found in the fungus WF5, has fungicidal activity, and is the lactonized form of homogentisic acid , an intermediate in aromatic amino acid metabolism.

8RK64 is a covalent inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1; IC50 = 0.32 µM) and a click chemistry reagent.

FDW028 is an inhibitor of fucosyltransferase 8 (FUC8).

FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.

AZD 5462 is an agonist of relaxin family peptide receptor 1 (RXFP1).

WLB-89462 is a ligand of sigma intracellular receptor 2 (σ2 receptor).