PFI-6 is a chemical probe for the YEATS domain-containing proteins MLLT1 and MLLT3 (IC50s = 140 and 160 nM, respectively).[1] It is selective for MLLT1 and MLLT3 over YEATS domain-containing 2 (YEATS2) and YEATS4 (IC50s = >30,000 nM for both).
References:
[1].Raux, B., Buchan, K.A., Bennett, J., et al.Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3Bioorg. Med. Chem. Lett.98129546(2024).