Pomalidomide 4’-PEG5-amine is a PEGylated form of the cereblon (CRBN) inhibitor pomalidomide .[1],[2] It has been conjugated to various ligands in the development of proteolysis-targeting chimeras (PROTACs).
References:
[1].Cheng-Sánchez, I., Gosselé, K.A., Palaferri, L., et al.Discovery and characterization of active CBP/EP300 degraders targeting the HAT domainACS Med. Chem. Lett.15(3)355-361(2024).
[2].Zhu, S., Liu, J., Xiao, D., et al.Design, synthesis, and biological evaluation of Wee1 kinase degradersEur. J. Med. Chem.243:114786(2022).