(±)2-HOTrE is an oxylipin.[1] It is active against the plant pathogenic fungi A. niger, S. cerevisiae, and P. membranae-faciens (MICs = 1.5, 3, and 1 g/L, respectively), as well as P. roqueforti, C. albicans, and C. valida (MICs = 2.33, 3, and 2 g/L, respectively). Hepatic levels of 2-HOTrE are increased in a mouse model of non-alcoholic fatty liver disease (NAFLD) induced by a high-fat diet.[2]
References:
[1].Liang, N., Dacko, A., Tan, A.K., et al.Structure-function relationships of antifungal monohydroxy unsaturated fatty acids (HUFA) of plant and bacterial originFood Res. Int.134109237(2020).
[2].Wu, Z., Xiao, H., Rao, D., et al.Analytical strategy for oxylipin annotation by combining chemical derivatization-based retention index algorithm and feature tandem mass spectrometric fragmentation as a biomarker discovery toolAnal. Chem.95(43)15933-15942(2023).