Tanzawaic acid B is a fungal metabolite that has been found in Penicillium and has diverse biological activities.[1],[2] It inhibits protein tyrosine phosphatase 1B (PTP1B) in a cell-free assay (IC50 = 8.2 µM) and LPS-induced production of nitric oxide (NO) in BV-2 microglia (IC50 = 42.5 µM).[1] Tanzawaic acid B is active against chloroquine-resistant and chloroquine-sensitive P. falciparum strains (IC50s = 78.5 and 79.2 µM, respectively).[2]
References:
[1].Quang, T.H., N.T.T., N., Ko, W., et al.Tanzawaic acid derivatives from a marine isolate of Penicillium sp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activitiesBiooorg. Med. Chem. Lett.24(24)5787-5791(2014).
[2].Matsuo, H., Hokari, R., Ishiyama, A., et al.Hatsusamides A and B: Two new metabolites produced by the deep-sea-derived fungal strain Penicillium steckii FKJ-0213Mar Drugs18(10)513(2020).