Homogentisic acid lactone is a fungal metabolite that has been found in the fungus WF5, has fungicidal activity, and is the lactonized form of homogentisic acid , an intermediate in aromatic amino acid metabolism.[1] It is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone has been used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity and the chemiluminescent detection of HRP release from liposomes.2,3 It is an intermediate in the synthesis of LD-2, a near-infrared probe for the imaging of lipid droplets in live cells.[4]
References:
[1].Mousa, W.K., Schwan, A.L., and Raizada, M.N.Characterization of antifungal natural products isolated from endophytic fungi of finger millet (Eleusine coracana)Molecules21(9)1171(2016).
[2].Bełtowski, J., Wójcicka, G., and Jamroz, A.Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: The possible novel mechanism for proatherogenic effect of chronic hyperleptinemiaAtherosclerosis170(1)21-29(2003).
[3].Kamidate, T., Kikuchi, N., Ishida, A., et al.Determination of peroxidase encapsulated in liposomes using homogentisic acid γ-lactone chemiluminescenceAnal. Sci.21(6)701-704(2005).
[4].Wu, X., Wang, X., Li, Y., et al.A near-infrared probe for specific imaging of lipid droplets in living cellsAnal. Chem.94(11)4881-4888(2022).