Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC4039411-deoxy CorticosteroneCAS: 64-85-7纯度: >99.50% / >99.00%
11-deoxy Corticosterone是一种由肾上腺产生的类固醇激素，具有盐皮质激素活性，并作为醛固酮的前体。
- GC40442(±)8-HETECAS: 79495-84-4纯度: >98.00%
A monohydroxy fatty acid produced by the non-enzymatic oxidation of arachidonic acid
- GC4044812(S)-HETECAS: 54397-83-0纯度: >98.00%
The predominant lipoxygenase product of mammalian platelets
- GC40480α-Phenyl-α-(2-pyridyl)acetonitrileCAS: 5005-36-7纯度: >98.00%
The major metabolite of α-phenyl-α-(2-pyridyl)thioacetamide
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC40380 | 5-OxoETE | 106154-18-1 | >95.00% | |
A polyunsaturated keto acid?that stimulates neutrophil migration | ||||
| GC40382 | 8(S)-HEPE | 118492-81-2 | >98.00% | |
A monohydroxy fatty acid produced by lipoxygenase oxidation of EPA | ||||
| GC40383 | 9(S)-HEPE | 141545-44-0 | >98.00% | |
A monohydroxy fatty acid derived from EPA | ||||
| GC40394 | 11-deoxy Corticosterone | 64-85-7 | >99.50% / >99.00% | |
11-deoxy Corticosterone是一种由肾上腺产生的类固醇激素，具有盐皮质激素活性，并作为醛固酮的前体。 | ||||
| GC40399 | Linoelaidic Acid | 506-21-8 | >98.00% | |
An all-trans fatty acid homolog of linoleic acid | ||||
| GC40427 | 15(S)-HEDE | 92693-04-4 | >98.00% | |
Isolated by the chromatographic resolution of (±)15-HEDE | ||||
| GC40442 | (±)8-HETE | 79495-84-4 | >98.00% | |
A monohydroxy fatty acid produced by the non-enzymatic oxidation of arachidonic acid | ||||
| GC40445 | 11(R)-HETE | 73347-43-0 | >98.00% | |
An oxylipin | ||||
| GC40447 | 12(R)-HETE | 82337-46-0 | >98.00% | |
An active metabolite of arachidonic acid | ||||
| GC40448 | 12(S)-HETE | 54397-83-0 | >98.00% | |
The predominant lipoxygenase product of mammalian platelets | ||||
| GC40451 | 15(S)-HETE | 54845-95-3 | >98.00% | |
An active metabolite of arachidonic acid | ||||
| GC40459 | 5(R)-HETE | 61641-47-2 | >98.00% | |
A rare lipoxygenase product of arachidonic acid | ||||
| GC40462 | 8(R)-HETE | 105500-09-2 | >98.00% | |
A product of lipoxygenation of arachidonic acid in marine invertebrates | ||||
| GC40463 | 8(S)-HETE | 98462-03-4 | >98.00% | |
A PKC and PPARα activator | ||||
| GC40480 | α-Phenyl-α-(2-pyridyl)acetonitrile | 5005-36-7 | >98.00% | |
The major metabolite of α-phenyl-α-(2-pyridyl)thioacetamide | ||||
| GC40495 | DL-Mevalonolactone | 674-26-0 | >98.00% | |
A precursor in the mevalonate pathway | ||||
| GC40529 | 7-hydroxy Warfarin | 17834-03-6 | - | |
A phase I metabolite of (-)-warfarin | ||||
| GC40538 | Decylubiquinone | 55486-00-5 | >98.00% | |
An analog of ubiquinone (coenzyme Q 10 ) | ||||
| GC40539 | (±)12(13)-EpOME | - | >98.00% | |
The 12,13-cis epoxide form of linoleic acid | ||||
| GC40542 | 9(R)-HODE | 10075-11-3 | >98.00% | |
A linoleic acid metabolite | ||||
| GC40555 | Tiopronin | 1953-02-2 | >98.00% | |
Tiopronin is an antioxidant that has diverse biological activities. | ||||
| GC40609 | Lipoxin A5 | 110657-98-2 | >95.00% | |
An EPA-derived bronchoconstrictor | ||||
| GC40612 | Resolvin E1 | 552830-51-0 | >95.00% | |
A specialized pro-resolving mediator | ||||
| GC40616 | Des-4-fluorobenzyl Mosapride | 152013-26-8 | >96.00% | |
A metabolite of mosapride | ||||