Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC40218(-)-Epigallocatechin Gallate-d3/d4纯度: >99.00%
An internal standard for the quantification of (–)-epigallocatechin gallate
- GC40220Pravastatin-d3 (sodium salt)CAS: 1329836-90-9纯度: >99.00%
An internal standard for the quantification of pravastatin
- GC40221Ritonavir-d6CAS: 1217720-20-1纯度: >99.00%
An internal standard for the quantification of ritonavir
- GC40229(±)-Warfarin-d5CAS: 75472-93-4纯度: >99.00%
An internal standard for the quantification of warfarin
- GC40234Ramipril-d5CAS: 1132661-86-9纯度: >99.00%
An internal standard for the quantification of ramipril
- GC40256p-APMSF (hydrochloride)CAS: 74938-88-8纯度: >95.00%
An irreversible inhibitor of serine proteases
- GC4037112(S)-HEPECAS: 116180-17-7纯度: >98.00%
An anti-inflammatory monohydroxy fatty acid derived from EPA
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC40191 | Ibuprofen Carboxylic Acid | 15935-54-3 | >98.00% | |
A major metabolite of ibuprofen | ||||
| GC40218 | (-)-Epigallocatechin Gallate-d3/d4 | - | >99.00% | |
An internal standard for the quantification of (–)-epigallocatechin gallate | ||||
| GC40220 | Pravastatin-d3 (sodium salt) | 1329836-90-9 | >99.00% | |
An internal standard for the quantification of pravastatin | ||||
| GC40221 | Ritonavir-d6 | 1217720-20-1 | >99.00% | |
An internal standard for the quantification of ritonavir | ||||
| GC40229 | (±)-Warfarin-d5 | 75472-93-4 | >99.00% | |
An internal standard for the quantification of warfarin | ||||
| GC40234 | Ramipril-d5 | 1132661-86-9 | >99.00% | |
An internal standard for the quantification of ramipril | ||||
| GC40252 | Phosphatidic Acids (egg) (ammonium salt) | - | >98.00% | |
A mixture of phosphatidic acids | ||||
| GC40256 | p-APMSF (hydrochloride) | 74938-88-8 | >95.00% | |
An irreversible inhibitor of serine proteases | ||||
| GC40259 | (±)-β-Tocopherol | 148-03-8 | >99.50% | |
A lipid-soluble form of vitamin E | ||||
| GC40260 | (±)-γ-Tocopherol | 7616-22-0 | >95.00% | |
A form of vitamin E | ||||
| GC40265 | Pheleuin | 169195-23-7 | >98.00% | |
A pyrazinone | ||||
| GC40278 | Leukotriene B3 | 88099-35-8 | >97.00% | |
The LTA hydrolase metabolite of LTA 3 | ||||
| GC40286 | (E,Z)-2-propyl-2-Pentenoic Acid | 60218-41-9 | >98.00% | |
A valproic acid metabolite | ||||
| GC40298 | N-acetyl-5-Aminosalicylic Acid | 51-59-2 | >98.00% | |
A metabolite of 5-ASA and sulfasalazine | ||||
| GC40301 | Tamoxifen N-oxide | 75504-34-6 | >98.00% | |
A metabolite of tamoxifen | ||||
| GC40339 | Hepoxilin A3 methyl ester | - | >98.00% | |
A metabolite of arachidonic acid | ||||
| GC40349 | 12(S)-HETE-19,20-alkyne | - | >97.00% | |
A probe for 12(S)-HETE activity | ||||
| GC40357 | 9(S)-HpODE | 29774-12-7 | >98.00% | |
A 5-LO product derived from linoleic acid | ||||
| GC40368 | 11(R)-HEPE | 109430-11-7 | >98.00% | |
Produced by the oxidation of EPA by 11(R)-LO | ||||
| GC40371 | 12(S)-HEPE | 116180-17-7 | >98.00% | |
An anti-inflammatory monohydroxy fatty acid derived from EPA | ||||
| GC40372 | 12-OxoETE | 108437-64-5 | >90.00% | |
A 12-oxo derivative of arachidonic acid | ||||
| GC40373 | 15(S)-HEPE | 86282-92-0 | >98.00% | |
A monohydroxy fatty acid derived from EPA | ||||
| GC40376 | 15-OxoETE | 81416-72-0 | >98.00% | |
An oxylipin produced by oxidation of the 15-hydroxyl of 15-HETE | ||||
| GC40378 | 5(S)-HEPE | 92008-51-0 | >98.00% | |
A fatty acid produced by 5-LO oxidation of EPA | ||||