Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC39848Indole-2-carboxylic acidCAS: 1477-50-5纯度: >99.50%
Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation.
- GC40007Malformin ACAS: 3022-92-2纯度: >95.00%
A cyclopentapeptide fungal metabolite with diverse biological activities
- GC40038Heptanoyl-L-carnitine (chloride)CAS: 162041-08-9纯度: >95.00% / >98.00%
Heptanoyl-L-carnitine (chloride)是L-肉碱的衍生物，L-肉碱是一种在脂肪酸转运至线粒体进行β-氧化过程中发挥关键作用的化合物。Heptanoyl-L-carnitine (chloride)在生物化学研究中被广泛用于研究代谢过程和线粒体功能。
- GC400877α-hydroxy-4-Cholesten-3-oneCAS: 3862-25-7纯度: >98.00% / >99.00%
7α-Hydroxy-4-cholesten-3-one是一种由胆固醇合成胆汁酸的中间体，是pregnane X receptor（PXR）激动剂。
- GC40099Leukotriene D4 MaxSpec® StandardCAS: 73836-78-9纯度: >95.00% / >97.00%
An active metabolite of LTC 4 and a constituent of SRS-A
- GC40118Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt)纯度: >95.00%
An inhibitor of caspase-8 and granzyme B
- GC40123Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt)纯度: >95.00%
A non-selective caspase inhibitor
- GC40141C18 Phytoceramide-d3 (t18:0/18:0-d3)CAS: 1354806-91-9纯度: >99.00%
An internal standard for the quantification of C18 phytoceramide
- GC40164Ac-IETD-CHO (trifluoroacetate salt)纯度: >95.00%
Ac-IETD-CHO (trifluoroacetate salt)是一种caspase 8抑制剂，可阻止focal adhesion kinase (Fak)被caspase裂解，IC 50 值为200nM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC39848 | Indole-2-carboxylic acid | 1477-50-5 | >99.50% | |
Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. | ||||
| GC40007 | Malformin A | 3022-92-2 | >95.00% | |
A cyclopentapeptide fungal metabolite with diverse biological activities | ||||
| GC40008 | Fuscin | 83-85-2 | >95.00% | |
A fungal metabolite with diverse biological activities | ||||
| GC40018 | Donepezil N-oxide | 120013-84-5 | >98.00% | |
An active metabolite of donepezil | ||||
| GC40029 | 9(S),10(S),13(S)-TriHOME | 135214-44-7 | >98.00% | |
An oxylipin | ||||
| GC40032 | Antipain (hydrochloride) | 37682-72-7 | >95.00% | |
Antipain (hydrochloride)是一种可逆性蛋白酶抑制剂。 | ||||
| GC40037 | Linoleoyl-L-carnitine (chloride) | 173686-75-4 | >98.00% | |
A long-chain acylcarnitine | ||||
| GC40038 | Heptanoyl-L-carnitine (chloride) | 162041-08-9 | >95.00% / >98.00% | |
Heptanoyl-L-carnitine (chloride)是L-肉碱的衍生物，L-肉碱是一种在脂肪酸转运至线粒体进行β-氧化过程中发挥关键作用的化合物。Heptanoyl-L-carnitine (chloride)在生物化学研究中被广泛用于研究代谢过程和线粒体功能。 | ||||
| GC40087 | 7α-hydroxy-4-Cholesten-3-one | 3862-25-7 | >98.00% / >99.00% | |
7α-Hydroxy-4-cholesten-3-one是一种由胆固醇合成胆汁酸的中间体，是pregnane X receptor（PXR）激动剂。 | ||||
| GC40097 | 4-HOBA | 696-60-6 | >98.50% / >98.00% | |
An isomer of 2-HOBA | ||||
| GC40099 | Leukotriene D4 MaxSpec® Standard | 73836-78-9 | >95.00% / >97.00% | |
An active metabolite of LTC 4 and a constituent of SRS-A | ||||
| GC40101 | IMP-1088 | 2059148-82-0 | >95.00% | |
IMP-1088是一种针对人类N-豆蔻酰转移酶NMT1和NMT2的皮摩尔级双重抑制剂，对NMT1的IC 50 值为0.24nM，对NMT2的IC 50 值 < 1nM。 | ||||
| GC40118 | Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt) | - | >95.00% | |
An inhibitor of caspase-8 and granzyme B | ||||
| GC40122 | Ac-AAVALLPAVLLALLAP-DEVD-CHO (trifluoroacetate salt) | - | >95.00% | |
A caspase-3 inhibitor | ||||
| GC40123 | Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt) | - | >95.00% | |
A non-selective caspase inhibitor | ||||
| GC40125 | Z-VA-DL-D(OMe)-FMK (trifluoroacetate salt) | - | >95.00% | |
A pan-caspase inhibitor | ||||
| GC40141 | C18 Phytoceramide-d3 (t18:0/18:0-d3) | 1354806-91-9 | >99.00% | |
An internal standard for the quantification of C18 phytoceramide | ||||
| GC40143 | Dihydrotetrabenazine | 3466-75-9 | >98.00% | |
An active metabolite of tetrabenazine | ||||
| GC40144 | Levofloxacin N-oxide | 117678-38-3 | >95.00% | |
An inactive metabolite of levofloxacin | ||||
| GC40145 | (S)-Laudanosine | 2688-77-9 | >98.00% | |
The (S) enantiomer of laudanosine | ||||
| GC40149 | Boc-AEVD-CHO (trifluoroacetate salt) | - | >95.00% | |
An inhibitor of caspase-8 | ||||
| GC40164 | Ac-IETD-CHO (trifluoroacetate salt) | - | >95.00% | |
Ac-IETD-CHO (trifluoroacetate salt)是一种caspase 8抑制剂，可阻止focal adhesion kinase (Fak)被caspase裂解，IC 50 值为200nM。 | ||||
| GC40183 | 1-Oleoyl Glycerol | 111-03-5 | >99.00% | |
A monoacylglycerol | ||||
| GC40190 | Febuxostat Acyl Glucuronide | 1351692-92-6 | >98.00% | |
A metabolite of febuxostat | ||||