GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC63040 structure
    GC63040L-Cysteic acid monohydrate
    CAS: 23537-25-9
    纯度: >98.00%

    L-Cysteic acid monohydrate (CAM) is an active endogenous metabolite.

  • GC63042 structure
    GC63042Levothyroxine acyl glucuronide
    CAS: 909880-81-5

    Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide) 是一种内源性代谢物，是甲状腺素 (T4) 的酰基葡萄糖醛酸形式。

  • GC63071 structure
    GC63071Methyl β-D-Galactopyranoside
    CAS: 1824-94-8

    Methyl β-D-Galactopyranoside (Methyl beta-D-galactoside, Methylgalactoside) is an endogenous metabolite.

  • GC63084 structure
    GC63084Mucic acid
    CAS: 526-99-8

    A monosaccharide

  • GC63092 structure
    GC63092N-Acetyl-L-arginine dihydrate
    CAS: 210545-23-6

    N-Acetyl-L-arginine (Ac-Arg-OH) dihydrate is an endogenous metabolite.

  • GC63093 structure
    GC63093N-Acetyloxytocin
    CAS: 10551-48-1

    N-Acetyloxytocin 是在大鼠垂体神经中间叶 (NIL) 中分离出来的，其存在于大鼠的几个脑区。

  • GC63102 structure
    GC63102neo-Inositol
    CAS: 488-54-0

    neo-Inositol 是肌醇的一个立体异构体，可从牛脑中分离得到。

  • GC63106 structure
    GC63106NHC-diphosphate triammonium
    纯度: >98.50%

    NHC-triphosphate triammonium 是 NHC 的活性胞内磷酸盐代谢物 (intracellular metabolite )，以三磷酸盐的形式存在。NHC-triphosphate triammonium 是病毒聚合酶 (viral polymerase) 的弱底物替代物，会被并入 HCV 复制子 RNA 中。

  • GC63107 structure
    GC63107NHC-triphosphate tetraammonium
    纯度: >96.00% / >97.00%

    NHC-triphosphate tetraammonium 是 NHC 的活性胞内磷酸盐代谢物 (intracellular metabolite )，以三磷酸盐的形式存在。NHC-triphosphate tetraammonium 是病毒聚合酶 (viral polymerase) 的弱底物替代物，会被并入 HCV 复制子 RNA 中。

  • GC63113 structure
    GC63113N-Methylphenethylamine
    CAS: 589-08-2
    纯度: >98.00%

    N-Methylphenethylamine 一种天然的仲胺类神经调节剂 (neuromodulator)，可在人的尿液或植物中检测到。

  • GC63116 structure
    GC63116Normetanephrine hydrochloride
    CAS: 1011-74-1

    Normetanephrine ((±)-Normetanephrine) hydrochloride 是去甲肾上腺素 (ne) 的 O-甲基化代谢产物。

  • GC63119 structure
    GC63119NT1-O12B
    CAS: 2739805-63-9

    NT1-O12B 是一种内源性化学物质，也是一种神经递质衍生的类脂质体 (NT-lipidoid)，是几种血脑屏障 (BBB) 非渗透性物质增强脑内转运的有效载体。将 NT1-O12B 掺杂到 BBB 非渗透性脂质纳米粒 (LNPs) 中，可以使 LNPs 具有穿过 BBB 的能力。NT 类脂质体不仅有利于 BBB 的跨膜转运，而且可以将其转运到神经细胞中进行功能基因沉默或基因重组。

  • GC63132 structure
    GC63132Otaplimastat
    CAS: 1176758-04-5

    Otaplimastat (SP-8203) 是一种基质金属蛋白酶 (MMP) 抑制剂，以竞争方式阻断 NMDA 受体介导的兴奋性毒性。Otaplimastat 还具有抗氧化活性。Otaplimastat 可用于脑缺血损伤的研究。

  • GC63136 structure
    GC63136Palatinose hydrate
    CAS: 343336-76-5
    纯度: >98.00%

    Isomaltulose (Palatinose) hydrate is a disaccharide carbohydrate widely used during exercise to maintain glycaemia and hydration.

  • GC63140 structure
    GC63140Pentane-1,5-diamine dihydrochloride
    CAS: 1476-39-7

    1,5-Diaminopentane (Cadaverine) is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue.

  • GC63152 structure
    GC63152Potassium 2-hydroxy-2-methylsuccinate
    CAS: 1030365-02-6

    Potassium 2-hydroxy-2-methylsuccinate 是一种内源性代谢产物。

  • GC63161 structure
    GC63161Pyrimidine
    CAS: 289-95-2
    纯度: >99.50%

    Pyrimidine 是一种内源性代谢产物。

  • GC63166 structure
    GC63166Raffinose
    CAS: 512-69-6
    纯度: >98.00%

    Raffinose (Melitose, Melitriose) is a complex carbohydrate, a trisaccharide composed of galactose, fructose, and glucose. It can be broken apart into galactose and sucrose via the enzyme alpha-galactosidase.

  • GC63168 structure
    GC63168rel-(2R,3S)-2,3-Dihydroxysuccinic acid hydrate
    CAS: 5990-63-6

    rel-(2R,3S)-2,3-Dihydroxysuccinic acid (hydrate) 是一种内源性代谢产物。

  • GC63170 structure
    GC63170Retagliptin
    CAS: 1174122-54-3
    纯度: >98.50%

    Retagliptin (SP2086) 是一种选择性的竞争性，且具有口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。Retagliptin 可用于 2 型糖尿病 (T2DM) 的研究。

  • GC63179 structure
    GC63179S-Adenosyl-L-methionine iodide
    CAS: 3493-13-8
    纯度: >80.00%

    S-(5’-Adenosyl)-L-methionine iodide (S-Adenosyl-L-methionine iodide) 是很重要的甲基供体，存在于所有生物体中。

  • GC63183 structure
    GC63183Secaubryenol
    CAS: 925932-08-7

    Secaubryenol 是一类从 Coussarea macrophylla 中分离的 3,4-七环烷三萜。Secaubryenol 在 10 µg/mL 的剂量下不显示任何细胞毒性。

  • GC63233 structure
    GC63233Toltrazuril sulfoxide
    CAS: 69004-15-5

    Toltrazuril sulfoxide 是托曲脲短暂的中间代谢物 (intermediary metabolite)，在体内可代谢为活性的托曲脲砜 (TZR-SO2)。Toltrazuril 是一种抗原生动物 (antiprotozoal agent) 试剂，作用于 Coccidia 球虫寄生虫。

  • GC63235 structure
    GC63235Trans-2-butene-1,4-dicarboxylic acid
    CAS: 4436-74-2
    纯度: >98.50%

    trans-β-Hydromuconic acid (trans-2-Butene-1,4-dicarboxylic Acid, 3-hexenediodicacid, β-Hydromuconic acid) is a normal human unsaturated dicarboxylic acid metabolite with increased excretion in patients with Dicarboxylic aciduria caused by fatty acid metabolism disorders.