Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC627842-Phenylbutanoic acidCAS: 90-27-7
2-Phenylbutyric acid (alpha-Phenylbutyric acid, alpha-phenylbutyrate, alpha-Ethylphenylacetic acid), belongs to the class of organic compounds known as phenylpropanes, is used as an anticholesteremic.
- GC627883-(2,4-Dihydroxyphenyl)propanoic acidCAS: 5631-68-5纯度: >98.00%
Hydroumbellic acid (2,4-Dihydroxyhydrocinnamic acid) is used as pharmaceutical intermediates.
- GC627893-(2-Hydroxyphenyl)propanoic acidCAS: 495-78-3
3-(2-Hydroxyphenyl)propanoic acid (Melilotic acid, Melilotate, 2-hydroxybenzenepropanoic acid) is an endogenous metabolite.
- GC627933-Amino-2-oxazolidinoneCAS: 80-65-9纯度: >98.00%
3-Amino-2-oxazolidinone (AOZ) 是呋喃唑烷酮 的代谢物 (metabolite)。3-Amino-2-oxazolidinone 作为检测呋喃唑烷酮残留的一个指标。
- GC627953-Methylhistamine dihydrochlorideCAS: 36475-47-5
3-Methylhistamine dihydrochloride 是一种内源性代谢产物。
- GC627973-Oxo-4,6-choladien-24-oic acidCAS: 88179-71-9
3-Oxo-4,6-choladien-24-oic acid 是一种内源性代谢物。3-Oxo-4,6-choladien-24-oic acid 存在于肝胆疾病患者的尿液中。
- GC627983-Phenylbutyric acidCAS: 4593-90-2纯度: >99.50%
3-Phenylbutyric acid 通过苯环的初始氧化和侧链的初始氧化而代谢，可用于从堆肥土壤中分离出紫红红球菌 (Rhodococcus rhodochrous) PB1。
- GC628004,4’-Disulfanediylbis(2-aminobutanoic acid)CAS: 462-10-2纯度: >95.00%
An oxidized dimeric form of homocysteine
- GC628034-FormylaminoantipyrineCAS: 1672-58-8
4-Formylaminoantipyrine 是氨基苯那酮的排泄代谢物 (metabolite)。Aminophenazone 是一种具有镇痛、抗炎、解热作用的吡唑啉酮。
- GC628105-Hydroxytryptamine creatinine sulfate monohydrateCAS: 61-47-2
Serotonin (5-Hydroxytryptamine) creatinine sulfate monohydrate is an active endogenous metabolite.
- GC628115-Methoxy-5-oxopentanoic acidCAS: 1501-27-5纯度: >98.50%
Monomethyl glutaric acid (5-Methoxy-5-oxopentanoic acid) is a dicarboxylic acid monoester and has a role as a human urinary metabolite.
- GC628145-Phenylvaleric acidCAS: 2270-20-4
5-Phenylvaleric acid (Benzenepentanoic acid, Phenylpentanoic acid, Phenylvaleric Acid) is a Pentanoic acid of bacterial origin, occasionally found in human biofluids.
- GC628166-Hydroxypyridin-2(1H)-one hydrochlorideCAS: 10357-84-3
6-Hydroxypyridin-2(1H)-one hydrochloride 是一种内源性代谢产物。
- GC628177-Methylguanosine 5’-diphosphate sodiumCAS: 104809-16-7纯度: >97.00%
7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium，一种 cap 类似物，可以用来合成 mRNA cap 类似物。
- GC62828Adenine monohydrochloride hemihydrateCAS: 6055-72-7纯度: >99.00%
Adenine monohydrochloride hemihydrate 是一种内源性代谢产物。
- GC62845Apoatropine hydrochlorideCAS: 5978-81-4纯度: >99.50%
Apoatropine hydrochloride 是从 Atropa belladonna 中分离出来的一种莨菪烷生物碱。
- GC62859Aβ42-IN-2CAS: 1914989-80-2纯度: >98.00%
Aβ42-IN-2 是一种 γ-secretase 调节剂，详细信息请参考专利文献 WO2016070107 中 的化合物 36。Aβ42-IN-2 对 αβ42 作用的 IC50 值为 6.5 nM 。Aβ42-IN-2 可用于阿尔茨海默症的研究。
- GC62883Calcium 2-hydroxy-4-(methylthio)butanoateCAS: 4857-44-7纯度: >97.00%
Calcium 2-hydroxy-4-(methylthio)butanoate is an active endogenous metabolite.
- GC62884Calcium L-ThreonateCAS: 70753-61-6纯度: >98.00%
L-Threonic acid Calcium Salt (Calcium threonate) is a calcium salt of threnoic acid. L-Threonic acid is a metabolite of ascorbic acid (vitamin C).
- GC62889Cathepsin D and E FRET Substrate acetate纯度: >99.00%
Cathepsin D and E FRET Substrate acetate 为 cathepins D 和 E 的荧光底物 (fluorogenic substrate)，而不是 B、H 或 I 的荧光底物，它的裂解发生在 Phe-Phe 酰胺键处。Cathepsin D and E FRET Substrate 是用于组织蛋白酶 D 和组织蛋白酶 E 的常规检测和机制研究的有用工具。(激发波长:328 nm; 发射波长:393 nm)
- GC62896Cholesterol glucuronideCAS: 17435-78-8
Cholesterol glucuronide 是一种由 UDP 葡萄糖醛酸转移酶在肝脏中产生的脂质的内源性代谢产物。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC62779 | 2-Methylcyclohexanone | 583-60-8 | >96.50% | |
2-Methylcyclohexanone 是一种内源性代谢产物。 | ||||
| GC62784 | 2-Phenylbutanoic acid | 90-27-7 | - | |
2-Phenylbutyric acid (alpha-Phenylbutyric acid, alpha-phenylbutyrate, alpha-Ethylphenylacetic acid), belongs to the class of organic compounds known as phenylpropanes, is used as an anticholesteremic. | ||||
| GC62788 | 3-(2,4-Dihydroxyphenyl)propanoic acid | 5631-68-5 | >98.00% | |
Hydroumbellic acid (2,4-Dihydroxyhydrocinnamic acid) is used as pharmaceutical intermediates. | ||||
| GC62789 | 3-(2-Hydroxyphenyl)propanoic acid | 495-78-3 | - | |
3-(2-Hydroxyphenyl)propanoic acid (Melilotic acid, Melilotate, 2-hydroxybenzenepropanoic acid) is an endogenous metabolite. | ||||
| GC62793 | 3-Amino-2-oxazolidinone | 80-65-9 | >98.00% | |
3-Amino-2-oxazolidinone (AOZ) 是呋喃唑烷酮 的代谢物 (metabolite)。3-Amino-2-oxazolidinone 作为检测呋喃唑烷酮残留的一个指标。 | ||||
| GC62795 | 3-Methylhistamine dihydrochloride | 36475-47-5 | - | |
3-Methylhistamine dihydrochloride 是一种内源性代谢产物。 | ||||
| GC62796 | 3-Methylvaleric Acid | 105-43-1 | >99.50% | |
3-Methylvaleric acid is a flavouring ingredient. | ||||
| GC62797 | 3-Oxo-4,6-choladien-24-oic acid | 88179-71-9 | - | |
3-Oxo-4,6-choladien-24-oic acid 是一种内源性代谢物。3-Oxo-4,6-choladien-24-oic acid 存在于肝胆疾病患者的尿液中。 | ||||
| GC62798 | 3-Phenylbutyric acid | 4593-90-2 | >99.50% | |
3-Phenylbutyric acid 通过苯环的初始氧化和侧链的初始氧化而代谢，可用于从堆肥土壤中分离出紫红红球菌 (Rhodococcus rhodochrous) PB1。 | ||||
| GC62800 | 4,4’-Disulfanediylbis(2-aminobutanoic acid) | 462-10-2 | >95.00% | |
An oxidized dimeric form of homocysteine | ||||
| GC62803 | 4-Formylaminoantipyrine | 1672-58-8 | - | |
4-Formylaminoantipyrine 是氨基苯那酮的排泄代谢物 (metabolite)。Aminophenazone 是一种具有镇痛、抗炎、解热作用的吡唑啉酮。 | ||||
| GC62810 | 5-Hydroxytryptamine creatinine sulfate monohydrate | 61-47-2 | - | |
Serotonin (5-Hydroxytryptamine) creatinine sulfate monohydrate is an active endogenous metabolite. | ||||
| GC62811 | 5-Methoxy-5-oxopentanoic acid | 1501-27-5 | >98.50% | |
Monomethyl glutaric acid (5-Methoxy-5-oxopentanoic acid) is a dicarboxylic acid monoester and has a role as a human urinary metabolite. | ||||
| GC62814 | 5-Phenylvaleric acid | 2270-20-4 | - | |
5-Phenylvaleric acid (Benzenepentanoic acid, Phenylpentanoic acid, Phenylvaleric Acid) is a Pentanoic acid of bacterial origin, occasionally found in human biofluids. | ||||
| GC62816 | 6-Hydroxypyridin-2(1H)-one hydrochloride | 10357-84-3 | - | |
6-Hydroxypyridin-2(1H)-one hydrochloride 是一种内源性代谢产物。 | ||||
| GC62817 | 7-Methylguanosine 5’-diphosphate sodium | 104809-16-7 | >97.00% | |
7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium，一种 cap 类似物，可以用来合成 mRNA cap 类似物。 | ||||
| GC62824 | Acetaminophen glucuronide | 16110-10-4 | - | |
An inactive metabolite of acetaminophen | ||||
| GC62828 | Adenine monohydrochloride hemihydrate | 6055-72-7 | >99.00% | |
Adenine monohydrochloride hemihydrate 是一种内源性代谢产物。 | ||||
| GC62845 | Apoatropine hydrochloride | 5978-81-4 | >99.50% | |
Apoatropine hydrochloride 是从 Atropa belladonna 中分离出来的一种莨菪烷生物碱。 | ||||
| GC62859 | Aβ42-IN-2 | 1914989-80-2 | >98.00% | |
Aβ42-IN-2 是一种 γ-secretase 调节剂，详细信息请参考专利文献 WO2016070107 中 的化合物 36。Aβ42-IN-2 对 αβ42 作用的 IC50 值为 6.5 nM 。Aβ42-IN-2 可用于阿尔茨海默症的研究。 | ||||
| GC62883 | Calcium 2-hydroxy-4-(methylthio)butanoate | 4857-44-7 | >97.00% | |
Calcium 2-hydroxy-4-(methylthio)butanoate is an active endogenous metabolite. | ||||
| GC62884 | Calcium L-Threonate | 70753-61-6 | >98.00% | |
L-Threonic acid Calcium Salt (Calcium threonate) is a calcium salt of threnoic acid. L-Threonic acid is a metabolite of ascorbic acid (vitamin C). | ||||
| GC62889 | Cathepsin D and E FRET Substrate acetate | - | >99.00% | |
Cathepsin D and E FRET Substrate acetate 为 cathepins D 和 E 的荧光底物 (fluorogenic substrate)，而不是 B、H 或 I 的荧光底物，它的裂解发生在 Phe-Phe 酰胺键处。Cathepsin D and E FRET Substrate 是用于组织蛋白酶 D 和组织蛋白酶 E 的常规检测和机制研究的有用工具。(激发波长:328 nm; 发射波长:393 nm) | ||||
| GC62896 | Cholesterol glucuronide | 17435-78-8 | - | |
Cholesterol glucuronide 是一种由 UDP 葡萄糖醛酸转移酶在肝脏中产生的脂质的内源性代谢产物。 | ||||