GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC62618 structure
    GC62618IPN60090
    CAS: 1853164-83-6
    纯度: >99.00%

    IACS-6274 (IPN60090), is a potent, selective and orally active glutaminase inhibitor with potential antineoplastic and immunostimulating activities.

  • GC62621 structure
    GC62621Milademetan tosylate hydrate
    CAS: 2095625-97-9
    纯度: >98.00%

    Milademetan (DS-3032) tosylate hydrate 是特异性的、具有口服活性的 MDM2 抑制剂，用于急性髓系白血病和实体肿瘤的研究。Milademetan (DS-3032) tosylate hydrate 可诱导 G1 细胞周期阻滞、衰老和凋亡。

  • GC62634 structure
    GC62634GSK-2793660
    CAS: 1613458-70-0

    GSK-2793660（游离碱）是一种口服的、不可逆的组织蛋白酶 C (CTSC) 抑制剂。

  • GC62662 structure
    GC62662WNK-IN-11 D3
    CAS: 2123483-49-6

    WNK-IN-11 D3 是一种具有口服活性、选择性和强效的 With-No-Lysine (WNK) 激酶抑制剂。WNK-IN-11 D3 有效调节心血管稳态。

  • GC62716 structure
    GC62716MD-222
    CAS: 2136246-72-3
    纯度: >99.00%

    MD-222 是一种首创的高效的基于 PROTAC 的 MDM2 降解剂。MD-222 诱导 MDM2 蛋白快速降解并激活细胞中的野生型 p53。MD-222 具有抗癌作用。

  • GC62721 structure
    GC62721DI-591
    CAS: 2245887-38-9
    纯度: >99.00%

    DI-591 是一种有效，高亲和力和细胞渗透性的 DCN1-UBC12 相互作用的抑制剂。DI-591 分别以 Ki 值为 12 nM 和 10.4 nM 与 DCN1 和 DCN2 结合，并且几乎不与 DCN3，DCN4 和 DCN5 蛋白结合。DI-591 选择性抑制 cullin 3 的二烯化，但对其他 cullin 家族成员的二烯化没有影响或影响很小。

  • GC62731 structure
    GC62731(2R,3R)-Butane-2,3-diol
    CAS: 24347-58-8
    纯度: >99.00%

    (2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) is an endogenous metabolite.

  • GC62734 structure
    GC62734(E)-Oct-2-enoic acid
    CAS: 1871-67-6
    纯度: >99.50%

    2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma.

  • GC62737 structure
    GC62737(R)-(-)-O-Desmethyl Venlafaxine D6
    CAS: 1062609-96-4

    (R)-(-)-O-Desmethyl Venlafaxine D6 是 (R)-(-)-O-Desmethyl Venlafaxine 的氘代物。O-Desmethyl Venlafaxine 是 Venlafaxine 的活性代谢产物。Venlafaxine 是 5-羟色胺-去甲肾上腺素再摄取抑制剂 (SNRI) 类的抗抑郁剂。

  • GC62744 structure
    GC62744(Rac)-OSMI-1
    CAS: 2748153-92-4
    纯度: >96.00%

    (Rac)-OSMI-1 是 OSMI-1 的外消旋体。OSMI-1 是一种 O-GlcNAc 转移酶 (OGT) 抑制剂，IC50 值为 2.7 μM。OSMI-1 抑制哺乳动物细胞系中的蛋白 O-连接的 N-乙酰氨基葡萄糖 (O-GlcNAcylation)，而没有定性地改变细胞表面 N-或 O-连接的聚糖。

  • GC62747 structure
    GC62747(S)-(-)-Citronellal
    CAS: 5949-05-3
    纯度: >98.00%

    (-)-Citronellal, a constituent of citronella oil, is used in the synthesis of bioactive compounds.

  • GC62748 structure
    GC62748(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate
    CAS: 18835-59-1

    3,5-Diiodotyrosine Dihydrate (Iodogorgoic acid, apothyrin, jodgorgon) is a product from the iodination of monoiodotyrosine. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones.

  • GC62749 structure
    GC62749(S)-3-Hydroxy-2-(Phosphonooxy)Propanoic Acid
    CAS: 23295-92-3

    (S)-3-Hydroxy-2-(Phosphonooxy)Propanoic Acid 是一种内源性代谢产物。

  • GC62751 structure
    GC62751(S)-Higenamine hydrobromide
    CAS: 105990-27-0

    (S)-Higenamine ((S)-Norcoclaurine) hydrobromide，Higenamine 的 S 型异构体，是苄基异喹啉生物碱生物合成的起始化合物，由去甲月桂碱合酶 (NCS) 将多巴胺和 4-羟基苯乙醛 (4-HPAA) 缩合生成。

  • GC62755 structure
    GC627551,4-D-Gulonolactone
    CAS: 6322-07-2

    1,4-D-Gulonolactone在易患坏血病、缺乏维生素 C 的动物（例如人类）中缺失。L-古洛糖酸内酯存在于人体血液中，已被用作比较运动引起的氧化应激变化的标志物之一。

  • GC62758 structure
    GC6275813-cis-Vitamin A palmitate
    CAS: 26771-20-0

    13 -cis-?retinyl hexadecanoate是十六烷酸的羧基与13-cis-retinol的羟基缩合而成的视黄酯,是由维生素A棕榈酸酯在玉米片中形成的13顺式异构体。13-顺式维生素 A 棕榈酸酯的生物活性是全反式维生素 A 棕榈酸酯的 75%，是维生素 A 中最具生物活性的形式。

  • GC62763 structure
    GC627632-(2’,3’,4’-Trihydroxybutyl)quinoxaline
    CAS: 42015-38-3

    2-(2’,3’,4’-Trihydroxybutyl)quinoxaline 是一种食物代谢物，可以由高葡聚糖形成。

  • GC62766 structure
    GC627662,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate
    CAS: 50887-69-9
    纯度: >99.50%

    2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate 是一种内源性代谢产物。

  • GC62767 structure
    GC6276723,25-Dihydroxy-24-oxovitamin D3
    CAS: 84164-55-6
    纯度: >99.50%

    23,25-Dihydroxy-24-oxovitamin D3 是 24(R),25-Dihydroxyvitamin D3 的主要代谢物。23,25-Dihydroxy-24-oxovitamin D3 可用于代谢性疾病的研究。

  • GC62769 structure
    GC627692-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
    CAS: 343-65-7

    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是一种内源性代谢产物。

  • GC62770 structure
    GC627702-Amino-5-ureidopentanoic acid
    CAS: 627-77-0
    纯度: >98.00%

    L-Citrulline (Citrulline, Cit) is a naturally occurring nonessential amino acid which is the key intermediate in the urea cycle.

  • GC62772 structure
    GC627722’-Deoxyadenosine-5’-triphosphate trisodium
    CAS: 54680-12-5
    纯度: >98.00%

    2’-Deoxyadenosine-5’-triphosphate trisodium (dATP trisodium) 是一种核苷酸，在细胞中用于 DNA 合成或复制。2’-Deoxyadenosine-5’-triphosphate (dATP) 是 DNA 聚合酶的底物。

  • GC62774 structure
    GC627742’-Deoxyguanosine 5’-monophosphate disodium
    CAS: 33430-61-4
    纯度: >99.00%

    2’-Deoxyguanosine 5’-monophosphate disodium (5′-dGMP disodium) 是一种以鸟嘌呤为核碱基的单核苷酸。2’-Deoxyguanosine 5’-monophosphate disodium 是核酸鸟苷三磷酸 (GTP) 的衍生物。

  • GC62777 structure
    GC627772-Methoxy-4-vinylphenol
    CAS: 7786-61-0
    纯度: >98.00%

    2-Methoxy-4-vinylphenol (2M4VP) 是天然的发芽抑制剂，具有抗炎活性。