Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC49291rac-N-desmethyl Ivabradine-d6 (hydrochloride)CAS: 2804269-05-2纯度: >99.00%
An internal standard for the quantification of N-desmethyl ivabradine
- GC492941-(4-Chlorobenzhydryl)piperazineCAS: 303-26-4纯度: >98.00%
An inactive metabolite of meclizine and chlorcyclizine
- GC492987α-ThiomethylspironolactoneCAS: 38753-77-4纯度: >95.00%
A major metabolite of spironolactone
- GC49316O-Desmethyl-N-deschlorobenzoyl IndomethacinCAS: 50995-53-4纯度: >95.00%
A metabolite of indomethacin
- GC493302-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride)CAS: 13473-53-5纯度: >95.00%
A metabolite of mazindol
- GC493374-AcetamidobenzenesulfonamideCAS: 121-61-9纯度: >98.00%
A metabolite of asulam and sulfanilamide
- GC49340Pitavastatin lactone-d4纯度: >99.00%
An internal standard for the quantification of pitavastatin lactone
- GC49355Norfluoxetine-d5 (hydrochloride)CAS: 1185132-92-6纯度: >99.00%
An internal standard for the quantification of norfluoxetine
- GC49359IM-156 (acetate)CAS: 2043654-54-0纯度: >98.00%
A mitochondrial complex I inhibitor and an AMPKα activator
- GC49382L-Lysine-d3 (hydrochloride)CAS: 2330878-43-6纯度: >99.00%
An internal standard for the quantification of L-lysine
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC49256 | N-acetyl Lenalidomide | 1421593-80-7 | >98.00% | |
A metabolite of lenalidomide | ||||
| GC49282 | Hydroxy Lenalidomide | 1421593-78-3 | >90.00% | |
A metabolite of lenalidomide | ||||
| GC49288 | Dolutegravir M1 | 1485081-26-2 | >95.00% | |
A metabolite of dolutegravir | ||||
| GC49289 | Dolutegravir O-β-D-Glucuronide | 1485692-21-4 | >95.00% | |
A metabolite of dolutegravir | ||||
| GC49291 | rac-N-desmethyl Ivabradine-d6 (hydrochloride) | 2804269-05-2 | >99.00% | |
An internal standard for the quantification of N-desmethyl ivabradine | ||||
| GC49294 | 1-(4-Chlorobenzhydryl)piperazine | 303-26-4 | >98.00% | |
An inactive metabolite of meclizine and chlorcyclizine | ||||
| GC49298 | 7α-Thiomethylspironolactone | 38753-77-4 | >95.00% | |
A major metabolite of spironolactone | ||||
| GC49315 | 5-hydroxy Indomethacin | 2504-32-7 | >98.00% | |
A metabolite of indomethacin | ||||
| GC49316 | O-Desmethyl-N-deschlorobenzoyl Indomethacin | 50995-53-4 | >95.00% | |
A metabolite of indomethacin | ||||
| GC49330 | 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride) | 13473-53-5 | >95.00% | |
A metabolite of mazindol | ||||
| GC49337 | 4-Acetamidobenzenesulfonamide | 121-61-9 | >98.00% | |
A metabolite of asulam and sulfanilamide | ||||
| GC49340 | Pitavastatin lactone-d4 | - | >99.00% | |
An internal standard for the quantification of pitavastatin lactone | ||||
| GC49349 | O-Desethyl Sildenafil | 139755-91-2 | >95.00% | |
A metabolite of sildenafil | ||||
| GC49355 | Norfluoxetine-d5 (hydrochloride) | 1185132-92-6 | >99.00% | |
An internal standard for the quantification of norfluoxetine | ||||
| GC49356 | 17(S)-HDoTE | 105835-39-0 | >98.00% | |
A metabolite of adrenic acid | ||||
| GC49359 | IM-156 (acetate) | 2043654-54-0 | >98.00% | |
A mitochondrial complex I inhibitor and an AMPKα activator | ||||
| GC49363 | Salicyluric Acid | 487-54-7 | >95.00% | |
A major metabolite of aspirin and salicylic acid | ||||
| GC49364 | 3-Hydroxycoumarin | 939-19-5 | >97.00% | |
A coumarin with diverse biological activities | ||||
| GC49365 | 25-Desacetyl Rifampicin | 16783-99-6 | >95.00% | |
A major active metabolite of rifampicin | ||||
| GC49366 | 1-Salicylate Glucuronide | 7695-70-7 | >95.00% | |
A metabolite of salicylic acid and aspirin | ||||
| GC49367 | 4’-hydroxy Atomoxetine Glucuronide (hydrate) | - | >95.00% | |
A metabolite of atomoxetine | ||||
| GC49382 | L-Lysine-d3 (hydrochloride) | 2330878-43-6 | >99.00% | |
An internal standard for the quantification of L-lysine | ||||
| GC49386 | Tepoxalin | 103475-41-8 | >98.00% | |
A dual inhibitor of COX and 5-LO | ||||
| GC49391 | 7α-Thiospironolactone | 38753-76-3 | >90.00% | |
An active metabolite of spironolactone | ||||