Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC49399N-Desbutyl Dronedarone (hydrochloride)CAS: 197431-02-0纯度: >95.00%
An active metabolite of dronedarone
- GC49421Atorvastatin lactone-d5CAS: 125995-03-1纯度: >99.00%
An internal standard for the quantification of atorvastatin lactone
- GC49428O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipineCAS: 113994-45-9纯度: >95.00%
A major metabolite of amlodipine
- GC49472Methylmalonic Acid-d3CAS: 42522-59-8纯度: >99.00%
An internal standard for the quantification of methylmalonic acid
- GC49479Hypoxanthine-d4CAS: 2483831-32-7纯度: >99.00%
An internal standard for the quantification of hypoxanthine
- GC49480Salicylic Acid-d4CAS: 78646-17-0纯度: >99.00% / >98.00%
An internal standard for the quantification of salicylic acid
- GC494886-Methylmercaptopurine-d3CAS: 33312-93-5纯度: >99.00%
An internal standard for the quantification of 6-MMP
- GC49529Thymidine-d4CAS: 347841-67-2纯度: >99.00%
An internal standard for the quantification of thymidine
- GC49559Hydroxymethyl Tolperisone (hydrochloride)CAS: 352233-14-8纯度: >95.00%
A metabolite of tolperisone
- GC49565RoxatidineCAS: 78273-80-0纯度: >95.00%
A histamine H 2 receptor antagonist and major active metabolite of roxatidine acetate
- GC49590Docosahexaenoic Acid 1,2,3,4-13C纯度: >95.00%
An internal standard for the quantification of DHA
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC49399 | N-Desbutyl Dronedarone (hydrochloride) | 197431-02-0 | >95.00% | |
An active metabolite of dronedarone | ||||
| GC49403 | Benzarone | 1477-19-6 | >98.00% | |
An active metabolite of benzbromarone | ||||
| GC49406 | ACT-373898 | 1433875-14-9 | >90.00% | |
A metabolite of macitentan | ||||
| GC49409 | Desmethyl Ranolazine | 172430-45-4 | >95.00% | |
A metabolite of ranolazine | ||||
| GC49410 | CVT-2738 | 5294-61-1 | >98.00% | |
An active metabolite of ranolazine | ||||
| GC49421 | Atorvastatin lactone-d5 | 125995-03-1 | >99.00% | |
An internal standard for the quantification of atorvastatin lactone | ||||
| GC49428 | O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine | 113994-45-9 | >95.00% | |
A major metabolite of amlodipine | ||||
| GC49437 | Gliotoxin-13C13 | - | >95.00% | |
An internal standard for the quantification of gliotoxin | ||||
| GC49454 | Complex 3 | 2480150-28-3 | >90.00% | |
A fluorescent copper complex with anticancer activity | ||||
| GC49457 | Oleoyl-Coenzyme A (sodium salt) | - | >95.00% / >90.00% / >70.00% | |
酰基辅酶A硫酯 | ||||
| GC49472 | Methylmalonic Acid-d3 | 42522-59-8 | >99.00% | |
An internal standard for the quantification of methylmalonic acid | ||||
| GC49479 | Hypoxanthine-d4 | 2483831-32-7 | >99.00% | |
An internal standard for the quantification of hypoxanthine | ||||
| GC49480 | Salicylic Acid-d4 | 78646-17-0 | >99.00% / >98.00% | |
An internal standard for the quantification of salicylic acid | ||||
| GC49488 | 6-Methylmercaptopurine-d3 | 33312-93-5 | >99.00% | |
An internal standard for the quantification of 6-MMP | ||||
| GC49501 | Nirvanol | 631-07-2 | >98.00% | |
An active metabolite of mephenytoin | ||||
| GC49511 | Nicorandil N-oxide | 107833-98-7 | >98.00% | |
A metabolite of nicorandil | ||||
| GC49529 | Thymidine-d4 | 347841-67-2 | >99.00% | |
An internal standard for the quantification of thymidine | ||||
| GC49538 | Lamotrigine N2-oxide | 136565-76-9 | >95.00% | |
A metabolite of lamotrigine | ||||
| GC49544 | 8-hydroxy Mirtazapine | 102335-57-9 | >95.00% | |
A metabolite of mirtazapine | ||||
| GC49559 | Hydroxymethyl Tolperisone (hydrochloride) | 352233-14-8 | >95.00% | |
A metabolite of tolperisone | ||||
| GC49565 | Roxatidine | 78273-80-0 | >95.00% | |
A histamine H 2 receptor antagonist and major active metabolite of roxatidine acetate | ||||
| GC49575 | 4-hydroxy Omeprazole sulfide | 103876-98-8 | >98.00% | |
A metabolite of omeprazole | ||||
| GC49583 | N-desmethyl Sertraline (hydrochloride) | 675126-09-7 | >95.00% | |
A metabolite of sertraline | ||||
| GC49590 | Docosahexaenoic Acid 1,2,3,4-13C | - | >95.00% | |
An internal standard for the quantification of DHA | ||||