Metabolism(代谢)

Cat.No. 产品名称 Information

GC38919 KY-226

抑制剂

KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.

GC38916 GNF362 GNF362 是肌醇三磷酸3'激酶 B (Itpkb) 的选择性，有效且可口服生物利用的抑制剂，IC50为 9 nM。 GNF362 还抑制 Itpka 和 Itpkc，IC50 值分别为 20 nM 和 19 nM。肌醇三磷酸3'激酶 B (Itpkb) 是一种 Ca2+ 依赖性激酶，其磷酸化 Ins (1,4,5) P3 的 3' 位置，生成肌醇 1,3,4,5-四磷酸 [Ins (1,3,4,5) P4]。

GC38890 Autotaxin-IN-3 Autotaxin-IN-3 是 Autotaxin(ATX) 抑制剂，IC50 值为 2.4 nM，源于专利 WO2018212534A1 中，化合物 33。

GC46030 3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) An ENPP1 inhibitor

GC46028 Malabaricone C

马拉巴酮C

A diarylnonanoid with diverse biological activities

GC46011 SPI 112 A cell-impermeable SHP-2 inhibitor

GC46009 1,2,3-Trioctanoyl-rac-glycerol-13C3

三辛酸甘油酯-1,1,1-13

An internal standard for the quantification of 1,2,3-trioctanoyl glycerol-¹³C₃

GC45997 Naftifine-d3 (hydrochloride)

盐酸萘替芬 d3 (盐酸盐)

An internal standard for the quantification of naftifine

GC45996 Octanoic Acid-d2

2,2-氘代辛酸(D2),Caprylic acid-d2

An internal standard for the quantification of octanoic acid

GC45995 DO264 An ABHD12 inhibitor

GC45992 Diallyl Tetrasulfide

二烯丙基四硫醚,ICD-1585

An organosulfur compound with diverse biological activities

GC45982 Octanoic Acid-d15

氘代辛酸(D15),Caprylic acid-d15

An internal standard for the quantification of octanoic acid

GC45981 Pristanic Acid-d3

降植烷酸

An internal standard for the quantification of pristanic acid

GC45976 Palmitic Acid-13C (C2 labeled)

棕榈酸 13C

An internal standard for the quantification of palmitic acid

GC45969 6β-hydroxy Eplerenone

依普利酮6-BETA-羟基类似物

A major metabolite of eplerenone

GC45956 1,2,3-Trinonanoyl-rac-glycerol

三壬酸甘油酯

A triacylglycerol

GC45945 Trihydroxycholestanoic Acid

粪甾烷酸,Trihydroxycoprostanic Acid

A cholic acid intermediate

GC38846 SBI-425 A TNAP inhibitor

GC38784 GKA50

GKA50 是一种有效的葡萄糖激酶 (glucokinase) 激活剂 (EC50=33 nM)。GKA50 刺激小鼠胰岛和 MIN6 细胞分泌胰岛素。GKA50 对高脂高脂脂肪雌性大鼠有显著的降糖作用。

GC38783 Ginkgolic acid C17:1

银杏酸 C17

A phenolic acid with antibacterial and anticancer activities

GC38759 CP-532623 CP-532623 是 CETP 抑制剂，可提高高密度脂蛋白胆固醇水平。CP-532623 与 Torcetrapib 的结构相似，并具有高度亲脂性。

GC38758 Clomethiazole

氯美噻唑

Chlormethiazole 是一种有效的口服 GABAA 激动剂。 Chlormethiazole 还可以抑制人肝微粒体中的细胞色素 P450 亚型: CYP2A6 和 CYP2E1。Chlormethiazole 有抗惊厥作用，具有治疗惊厥性癫痫的潜力。

GC45928 iFSP1

iFSP1是一种有效的不依赖谷胱甘肽的铁死亡抑制蛋白1（FSP1）抑制剂，其EC₅₀值为103nM。

GC45925 1-Palmitoyl-2-12-OAHSA-3-Oleoyl-sn-glycerol

16:0-12-OAHSA-18:1-TG, TG(16:0/12-OAHSA/18:1)

A neuropeptide with diverse biological activities

GC45924 1-Palmitoyl-2-10-OAHSA-3-Oleoyl-sn-glycerol

16:0-10-OAHSA-18:1-TG, TG(16:0/10-OAHSA/18:1)

A neuropeptide with diverse biological activities

GC45923 1-Palmitoyl-2-9-OAHSA-3-Oleoyl-sn-glycerol

16:0-9-OAHSA-18:1-TG, TG(16:0/9-OAHSA/18:1)

A neuropeptide with diverse biological activities

GC45922 (±)11(12)-EET-d11 methyl ester

(±)11,12-EpETrE-d11 methyl ester

A neuropeptide with diverse biological activities

GC45921 (±)8(9)-EET-d11 methyl ester

(±)8,9-EpETrE-d11 methyl ester

A neuropeptide with diverse biological activities

GC45920 (±)14(15)-EET-d11 methyl ester

(±)14,15-EpETrE-d11 methyl ester

A neuropeptide with diverse biological activities

GC45919 (±)5(6)-EET-d11 methyl ester

(±)5,6-EpETrE-d11 methyl ester

A neuropeptide with diverse biological activities

GC45915 1-Palmitoyl-2-10-PAHSA-3-Oleoyl-sn-glycerol

16:0-10-PAHSA-18:1-TG, TG(16:0/10-PAHSA/18:1)

A neuropeptide with diverse biological activities

GC45914 1-Palmitoyl-2-9-PAHSA-3-Oleoyl-sn-glycerol

TG(16:0/9-PAHSA/18:1)

A neuropeptide with diverse biological activities

GC45903 Quazinone

快嗪酮

A PDE3 inhibitor

GC45887 Bufuralol-d9 (hydrochloride)

丁呋洛尔-叔丁基-D9盐酸盐,Ro 3-4787-d9 hydrochloride

An internal standard for the quantification of bufuralol

GC45878 Tolnaftate-d7

托萘酯 D7

An internal standard for the quantification of tolnaftate

GC45841 4-Nitrophenyl-N-acetyl-β-D-glucosaminide

4-硝基苯基-2-乙酰胺基-2-脱氧-B-D-吡喃葡糖霉

A chromogenic substrate for N-acetyl-β-glucosaminidase

GC45833 N-Oleoyl-L-phenylalanine

18-1-Phe, C18:1-Phe

An N-acyl amide

GC45829 Troglitazone-d4

CS-045-d4

Troglitazone-d4 是氘标记的曲格列酮。 Troglitazone 是一种 PPARγ 激动剂，对人和鼠 PPARγ 受体的 EC50 分别为 550 nM 和 780 nM。

GC45820 Balsalazide-d4 Balsalazide-d4 是氘标记的 Balsalazide。

GC45813 Octanoic Acid-d3

8,8,8-氘代辛酸(D3),Caprylic acid-d3

An internal standard for the quantification of octanoic acid

GC45806 Tauro-ω-muricholic Acid (sodium salt)

T-ω-MCA, TOMCA

具有多种生物活性的神经肽

GC45802 Zonisamide-13C2,15N An internal standard for the quantification of zonisamide

GC45799 Tranexamic Acid-13C2,15N

AMCA-13C2,15N, TXA-13C2,15N

An internal standard for the quantification of tranexamic acid

GC45798 Rhein-13C4

1,8-二羟基-3-羧基蒽醌

An internal standard for the quantification of rhein

GC45793 IM-93 A dual inhibitor of ferroptosis and NETosis

GC45792 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

Iron Salophene Complex, N,N'-o-Phenylenebis(salicylideneaminato)iron(III) Chloride

An inducer of ferroptosis

GC45786 Lomitapide-d8

AEGR-733-d8; BMS-201038-d8

A neuropeptide with diverse biological activities

GC45779 Palmitic Acid-13C (C1 labeled)

棕榈酸 1-13C

An internal standard for the quantification of palmitic acid

GC45777 Peonidin 3-O-glucoside (chloride)

氯化葡萄糖苷芍药素

An anthocyanin with diverse biological activities

GC45764 Ciclopirox-d11 (sodium salt)

HOE 296b-d11

A neuropeptide with diverse biological activities