2-deoxy-D-Glucose-6-phosphate (sodium salt) is a derivative of 2-deoxy-D-glucose and possesses good water solubility and stability [1]. 2-Deoxy-D-Glucose-6-phosphate can accumulate within the cells, resulting in cell cycle arrest and inhibition of cell growth[2]. 2-Deoxy-D-Glucose-6-phosphate has been widely used as a model compound to investigate the characteristics of the binding sites and kinetic parameters for glycogen phosphorylase b[3].
References:
[1] Hopkins J C A, Radda G K, Veech R L, et al. Accumulation of 2-deoxy-D-glucose-6-phosphate as a measure of glucose uptake in the isolated perfused heart: a 31P NMR study[J]. Metabolic engineering, 2004, 6(1): 36-43.
[2] Pajak B, Siwiak E, Sołtyka M, et al. 2-Deoxy-d-glucose and its analogs: from diagnostic to therapeutic agents[J]. International journal of molecular sciences, 2019, 21(1): 234.
[3] Oikonomakos N G, Zographos S E, Johnson L N, et al. The Binding of 2-Deoxy-D-glucose 6-Phosphate to Glycogen Phosphorylaseb: Kinetic and Crystallographic Studies[J]. Journal of molecular biology, 1995, 254(5): 900-917.
2-deoxy-D-Glucose-6-phosphate (sodium salt)是2-脱氧-D-葡萄糖的衍生物，具有良好的水溶性和稳定性[1]。2-deoxy-D-Glucose-6-phosphate可在细胞内积累，导致细胞周期阻滞并抑制细胞生长[2]。2-deoxy-D-Glucose-6-phosphate已广泛作为模型化合物用于研究糖原磷酸化酶b的结合位点特性及动力学参数[3]。