GlpBio

Taurodeoxycholic Acid-d4 (sodium salt)

目录号: GC19797纯度: >99.00% deuterated forms (d1-d4)同义词: Sodium Taurodeoxycholate-d4; TDCA-d4
An internal standard for the quantification of taurodeoxycholic acid
Taurodeoxycholic Acid-d4 (sodium salt)
Cas No.: 2410279-82-0
规格价格库存数量操作
1mg¥3,318.00现货
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产品描述 Description

Taurodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of taurodeoxycholic acid by GC- or LC-MS. Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid [1] Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally.[2] Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.[1]

Reference:
[1]. Schmid, A., Neumann, H., Karrasch, T., et al. Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS). PLoS One 11(2), e0148869 (2016).
[2]. Hendrick, S.M., Mroz, M.S., Greene, C.M., et al. Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cells. Am. J. Physiol. Lung. Cell. Mol. Physiol. 307(5), L407-L418 (2014).

产品文档 Product Documents

Purity:>99.00% deuterated forms (d1-d4)Appearance:A crystalline solid

化学性质Chemical Properties

CAS 号
2410279-82-0
同义词
Sodium Taurodeoxycholate-d4; TDCA-d4
化学名
2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt
SMILES
[H][C@]12[C@@]([C@@](CC[C@]3([H])[C@H](C)CCC(NCCS(=O)([O-])=O)=O)([H])[C@]3(C)[C@@H](O)C2)([H])CC[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@@]41C.[Na+]
分子式
C26H40D4NO6S • Na
分子量
525.7 g/mol
溶解性
DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol