Metabolism(代谢)

Cat.No. 产品名称 Information

GC52071 10-oxo-12(Z)-Octadecenoic Acid

10-keto-12Z-Octadecenoic Acid, 10-oxo-12-cis-Octadecenoic Acid

A metabolite of linoleic acid and an activator of TRPV1

GC52064 UDP-N-acetyl-D-Galactosamine (sodium salt)

尿嘧啶核苷-5′-二磷酸-N-乙酰氨基半乳糖二钠盐

A nucleotide sugar

GC52062 7-Benzyloxy-4-(trifluoromethyl)coumarin

7-苄氧基-4-三氟甲基香豆素

A fluorogenic substrate for CYP1A2 and CYP3A

GC52060 Trimipramine N-oxide

10,11-二氢-N,N,BETA-三甲基-5H-二苯并[B,F]氮杂卓-5-丙胺N-氧化物

An active metabolite of trimipramine

GC52056 6(Z),9(Z),12(Z),15(Z)-Hexadecatetraenoic Acid ethyl ester

(6Z,9Z,12Z)-十六烷-6,9,12,15-四烯酸乙酯

A polyunsaturated fatty ester

GC52047 Fustin

黄颜木素,(±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone

A flavanone with diverse biological activities

GC52045 N-desmethyl Azelastine

氮卓斯汀杂质

An active metabolite of azelastine

GC52042 Hexahydrohippuric Acid

六氢马尿酸

A derivative of glycine

GC52038 Desthiazolylmethyl Ritonavir

利托那韦杂质L

A ritonavir degradation product

GC52026 10-oxo-12(Z),15(Z)-Octadecadienoic Acid

10-oxo-12(Z),15(Z)-18:2, 10-oxo-12(Z),15(Z)-ODE

An oxylipin gut microbiota metabolite

GC52024 Aripiprazole N-oxide

阿立哌唑-N1-氧化物

A metabolite of aripiprazole

GC52019 Norpropranolol (hydrochloride)

(±)-Desisopropylpropranolol, N-Desisopropylpropranolol

An active metabolite of propranolol

GC52013 (±)-10-hydroxy-12(Z)-Octadecenoic Acid

10-hydroxy-cis-12-Octadecenoic Acid

An oxylipin and metabolite of linoleic acid

GC52010 (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid

αHYA, (±)-10-hydroxy-12(Z),15(Z)-ODE

An oxylipin gut microbiota metabolite

GC52009 Isovaleryl-DL-carnitine-d9 (chloride)

CAR 5:0-d9, C5:0 Carnitine-d9, DL-Carnitine isovaleryl ester-d9, DL-Isovalerylcarnitine-d9

An internal standard for the quantification of isovaleryl-DL-carnitine

GC52007 N-hydroxylamine Dapsone

羟胺氨苯砜

An active metabolite of dapsone

GC19941 DL-Leucic Acid

GC19936 Quisinostat dihydrochloride

QUISINOSTAT二盐酸盐,JNJ-26481585 dihydrochloride

A pan-HDAC inhibitor

GC49890 β-Glycerophosphate-d5 (sodium salt hydrate)

Glycerol 2-Phosphate-d5

An internal standard for the quantification of β-glycerophosphate

GC49885 BQ-3020 (trifluoroacetate salt) A peptide ET_B receptor antagonist

GC49884 Trigonelline-d3 (chloride)

Trigonelline-d3 hydrochloride

An internal standard for the quantification of trigonelline

GC49879 Metformin hydroxy analog 2

二甲双胍杂质3

An oxidation product of metformin

GC49877 5-bromo-3-indolyl-β-D-Galactopyranoside

5-溴-3-吲哚基-beta-D-吡喃半乳糖苷,Bluo-Gal

A chromogenic substrate for β-galactosidase

GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride)

盐酸文拉法辛杂质D

A minor active metabolite of venlafaxine

GC49868 D-α-Tocopheryl Quinone

α-Tocopherylquinone

An oxidative metabolite of vitamin E

GC49866 Desmethyl Carvedilol

O-去甲卡维地洛

An active metabolite of carvedilol

GC49862 5α-Cholanic Acid-3,6-dione

NSC 18165

A secondary bile acid

GC49855 Harmalol (hydrochloride hydrate)

骆驼蓬酚盐酸盐(二水)

A β-carboline alkaloid and an active metabolite of harmaline

GC49851 Norquetiapine

11-(1-哌嗪基)二苯并[B,F][1,4]硫氮杂卓

An active metabolite of quetiapine

GC49848 16-Ketoestradiol

16-keto E2, NSC 51169, 16-Oxoestradiol

An active metabolite of estrone

GC49842 Digoxigenin Bisdigitoxoside

Bisdigoxigenin

A Na⁺/K⁺-ATPase inhibitor

GC49840 2-Methylbutyrylglycine

N-(2-甲基-1-氧代丁基)-甘氨酸

A metabolite of isoleucine

GC49832 Hydroxymetronidazole

羟基甲硝唑,Metronidazole-OH

An active metabolite of metronidazole

GC49827 5-Androstenetriol

Δ5-AT

An active metabolite of DHEA

GC49817 Desethoxy Quetiapine (hydrochloride)

喹硫平羟基杂质二盐酸盐

An active metabolite of quetiapine

GC49815 Oleuropein aglycone

3,4-DHPEA-EA

A polyphenol with diverse biological activities

GC49811 DX3-213B A mitochondrial complex I inhibitor

GC49790 Reuterin

罗氏菌素,3-Hydroxypropionaldehyde; 3-Hydroxypropanal

A bacterial glycerol metabolite with antibacterial activity

GC49784 AZD 2716 An sPLA₂ inhibitor

GC49782 L-Phenylalanine-13C6

L-苯丙氨酸-13C6,(S)-2-Amino-3-phenylpropionic acid-13C6

An internal standard for the quantification of phenylalanine

GC49771 rac-Hesperetin-d3

三氘代橙皮素

An internal standard for the quantification of hesperetin

GC49769 β-Glucogallin

1-没食子酸酰葡萄糖

A plant metabolite and an aldose reductase 2 inhibitor

GC49762 Etiocholanedione

雄甾-3,17-二酮

A neurosteroid

GC64370 Kongensin A Kongensin A 是一种从 Croton kongensis 中分离的天然产物。 Kongensin A 是一种有效的，共价的 HSP90 抑制剂，可阻断 RIP3 依赖性坏死病。Kongensin A 是一种有效的坏死性抑制剂和凋亡诱导剂，并具有潜在的抗坏死性和消炎性应用。

GC64352 L-Glutamic acid-15N

L-谷氨酸 15N

L-Glutamic acid-15N 是一种 15N 标记的 L-Glutamic acid。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。

GC64306 ROC-0929 ROC-0929 (compound 13a) 是一种有效且选择性的分泌型磷脂酶 A2 (sPLA2s) 抑制剂。其IC50值为 80 nM，特异性靶点为hGX。ROC-0929 抑制 ERK1/2 和 p-38 的磷酸化。分泌型磷脂酶 A2 (sPLA2s) 是富含二硫键的 Ca2+ 依赖性酶家族，可水解甘油磷脂的 sn-2 位以释放脂肪酸和溶血磷脂。ROC-0929具有研究炎症相关疾病的潜力。

GC64266 Enavogliflozin

DWP-16001

Enavogliflozin (DWP-16001) 作为一种抗糖尿病药物，是一种具有口服活性，一流的选择性钠-葡萄糖协同转运体 -2 (SGLT-2) 抑制剂。

GC64119 Saponarin

皂草甙

A flavonoid glycoside with diverse biological activities

GC64099 AZD-9574 AZD-9574是一种新型的、具有血脑屏障通透性的PARP1抑制剂，AZD-9574在SSB位点选择性抑制PARP1。

GC64074 DSM705 hydrochloride DSM705 hydrochloride，一种具有口服活性的抗疟化合物，是基于吡咯的二氢乳清酸脱氢酶 (DHODH) 抑制剂。DSM705 hydrochloride 对 Plasmodium DHODH 和 Plasmodium 寄生虫表现出纳摩尔级效力 (抑制 P. falciparum 和 P. vivax DHODH 的 IC50 分别为 95 nM 和 52 nM)，对哺乳动物 DHODH 没有抑制作用。