Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC74536TafolecimabCAS: 2225109-03-3纯度: >95.00%
Tafolecimab（IBI-306）特异性结合PCSK-9，并通过抑制PCSK-9介导的LDL受体的内吞作用来降低LDL-C水平，这反过来又增强了LDL-C的清除并导致LDL-C含量降低。
- GC746333-Hydroxyanthranilic acid-d3CAS: 1794970-56-1纯度: >99.00%
3-Hydroxyanthranilic acid-d3是氘标记的3-羟基邻氨基苯甲酸。
- GC746403-Amino-2-methylpropanoic acid-d3CAS: 1219803-65-2纯度: 不显示
3-Amino-2-methylpropanoic acid-d3是氘标记的3-氨基-2-甲基丙酸。
- GC746443-Methyl-D-histidine-d3 hydrochloride纯度: >96.00%
3-Methyl-D-histidine-d3 hydrochloride是氘标记的3-金属- d -组氨酸氯。
- GC74650D-Ribose(mixture of isomers)-13C5CAS: 202114-47-4纯度: >99.00%
D-Ribose(mixture of isomers)-13C5 isomers- 13c5是13C标记的d -核糖异构体混合物。
- GC747102-Methylbutyrylcarnitine chloride纯度: >98.00%
2-Methylbutyrylcarnitine chloride是一种肠道微生物代谢产物，与血小板中的整合素α2β1结合，增强细胞质磷脂酶A2（cPLA2）的活化和血小板的过度反应性。
- GC74728Butylated hydroxytoluene-d3CAS: 86819-59-2纯度: >98.00%
Butylated hydroxytoluene-d3是氘标记的丁基化羟基甲苯。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC74377 | Enlicitide chloride | 2407527-16-4 | >98.00% | |
Enlicitide chloride是一种有效的PCSK9拮抗剂。 | ||||
| GC74379 | Arg-Arg-AMC acetate | - | >98.00% | |
Arg-Arg-AMC acetate是Arg-Arg-AMC的醋酸盐形式。 | ||||
| GC74380 | Ac-VRPR-AMC TFA | - | >99.00% | |
Ac-VRPR-AMC TFA是一种荧光的metacaspase底物。 | ||||
| GC74381 | Bz-Ala-Arg TFA | - | >99.00% | |
Bz-Ala-Arg TFA是一种二肽。 | ||||
| GC74514 | Begelomab | 1403744-56-8 | >95.00% | |
Begelomab（SAND-26）是一种针对DPP-4/CD26的小鼠IgG2b单克隆抗体。 | ||||
| GC74536 | Tafolecimab | 2225109-03-3 | >95.00% | |
Tafolecimab（IBI-306）特异性结合PCSK-9，并通过抑制PCSK-9介导的LDL受体的内吞作用来降低LDL-C水平，这反过来又增强了LDL-C的清除并导致LDL-C含量降低。 | ||||
| GC74598 | Recaticimab | 2361290-85-7 | >99.00% | |
Recaticimab (shrr -1209)是一种抑制PCSK9的人源化单克隆抗体。 | ||||
| GC74633 | 3-Hydroxyanthranilic acid-d3 | 1794970-56-1 | >99.00% | |
3-Hydroxyanthranilic acid-d3是氘标记的3-羟基邻氨基苯甲酸。 | ||||
| GC74635 | Creatine-d3 | 143827-19-4 | >98.00% | |
Creatine-d3是氘标记的肌酸。 | ||||
| GC74640 | 3-Amino-2-methylpropanoic acid-d3 | 1219803-65-2 | 不显示 | |
3-Amino-2-methylpropanoic acid-d3是氘标记的3-氨基-2-甲基丙酸。 | ||||
| GC74641 | Suberic acid-d12 | 169397-99-3 | >98.00% | |
Suberic acid-d12是氘标记的苏比克酸。 | ||||
| GC74644 | 3-Methyl-D-histidine-d3 hydrochloride | - | >96.00% | |
3-Methyl-D-histidine-d3 hydrochloride是氘标记的3-金属- d -组氨酸氯。 | ||||
| GC74647 | Adipic acid-13C | 2708283-72-9 | >98.00% | |
Adipic acid-13C是13C标记的己二酸。 | ||||
| GC74649 | D-Ribose-d6 | - | >99.00% | |
D-Ribose-d6是氘标记的d -核糖。 | ||||
| GC74650 | D-Ribose(mixture of isomers)-13C5 | 202114-47-4 | >99.00% | |
D-Ribose(mixture of isomers)-13C5 isomers- 13c5是13C标记的d -核糖异构体混合物。 | ||||
| GC74657 | 1-Octanol-d17 | 153336-13-1 | >99.00% | |
1-Octanol-d17是氘标记的1-辛醇。 | ||||
| GC74668 | 3-Methoxy-9H-Carbazole | 18992-85-3 | >99.00% | |
3-Methoxy-9H-Carbazole诱导caspase-3活性和细胞产生活性氧。 | ||||
| GC74710 | 2-Methylbutyrylcarnitine chloride | - | >98.00% | |
2-Methylbutyrylcarnitine chloride是一种肠道微生物代谢产物，与血小板中的整合素α2β1结合，增强细胞质磷脂酶A2（cPLA2）的活化和血小板的过度反应性。 | ||||
| GC74728 | Butylated hydroxytoluene-d3 | 86819-59-2 | >98.00% | |
Butylated hydroxytoluene-d3是氘标记的丁基化羟基甲苯。 | ||||
| GC74729 | Urea-13C,15N2 | 58069-83-3 | >99.00% | |
Urea-13C,15N2为13C和15N标记的尿素。 | ||||
| GC74730 | Benzophenone-d5 | 2694-78-2 | >99.00% | |
Benzophenone-d5是氘标记的二苯甲酮。 | ||||
| GC90077 | Furin Inhibitor I (trifluoroacetate salt) | - | >95.00% | |
一种前蛋白酶转化酶抑制剂 | ||||
| GC90194 | Ethyl-β-D-Glucuronide-d5 | 1135070-98-2 | >99.00% | |
一种用于乙基-β-D-葡萄糖醛酸盐定量的内部标准 | ||||
| GC90472 | Cyano-myracrylamide | 2801702-34-9 | >98.00% | |
一种zDHHC20抑制剂 | ||||