Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC70812Guanosine 5'-triphosphate-5'-adenosine triammonium纯度: 不显示
Guanosine 5'-triphosphate-5'-adenosine triammonium5′帽类似物可用于体外RNA合成。
- GC70828Ninerafaxstat trihydrochlorideCAS: 2311824-72-1纯度: >99.00%
Ninerafaxstat trihydrochloride是一种新型促分裂剂。
- GC70837UDP-glucosamine disodiumCAS: 1355005-51-4纯度: >99.00%
UDP-glucosamine disodium是O-GlcNAc转移酶的底物，催化O-GlcNAc附着于蛋白质。
- GC70866SS(no Galnac)-Inclisiran sodium纯度: >95.00%
SS(no Galnac)-Inclisiran sodium是一个没有GalNAc的单stran Inclisiran。
- GC71006Cathepsin K inhibitor 6CAS: 325775-42-6纯度: >98.00%
Cathepsin K inhibitor 6（化合物19）是组织蛋白酶K（Cat K）的抑制剂，IC50为17nM。
- GC7104218β-Glycyrrhetyl-3-O-sulfateCAS: 10251-38-4纯度: >98.00%
18β-Glycyrrhetyl-3-O-sulfate（甘草次酸3-O-（硫酸氢））是一种强效的2型11β-羟基类固醇脱氢酶（11β-HSD2）抑制剂，使用大鼠肾微粒体时IC50为0.10µM。
- GC71084Tyrosinase-IN-12CAS: 1860779-42-5纯度: >99.00%
Tyrosinase-IN-12是一种强效的非竞争性酪氨酸酶抑制剂，IC50值为49.33±2.64µM，Ki值为31.25±0.25µM。
- GC71150O-Phospho-L-serine-13C3,15NCAS: 2734706-69-3纯度: 不显示
O-Phospho-L-serine-13C3,15N是13C和15N标记的O-磷酸-L-丝氨酸。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC70812 | Guanosine 5'-triphosphate-5'-adenosine triammonium | - | 不显示 | |
Guanosine 5'-triphosphate-5'-adenosine triammonium5′帽类似物可用于体外RNA合成。 | ||||
| GC70827 | Ninerafaxstat | 2254741-41-6 | >90.00% | |
Ninerafaxstat（IMB-1018972）是一种新型促分裂剂。 | ||||
| GC70828 | Ninerafaxstat trihydrochloride | 2311824-72-1 | >99.00% | |
Ninerafaxstat trihydrochloride是一种新型促分裂剂。 | ||||
| GC70837 | UDP-glucosamine disodium | 1355005-51-4 | >99.00% | |
UDP-glucosamine disodium是O-GlcNAc转移酶的底物，催化O-GlcNAc附着于蛋白质。 | ||||
| GC70845 | Z-FF-FMK | 105608-85-3 | >98.00% | |
Z-FF-FMK是一种选择性组织蛋白酶- l抑制剂。 | ||||
| GC70858 | PG 116800 | 291533-11-4 | 不显示 | |
PG 116800 (PG 530742)是一种口服活性MMP抑制剂。 | ||||
| GC70865 | SS-Inclisiran sodium | - | >98.00% | |
SS-Inclisiran sodium是Inclisiran的一个感官链。 | ||||
| GC70866 | SS(no Galnac)-Inclisiran sodium | - | >95.00% | |
SS(no Galnac)-Inclisiran sodium是一个没有GalNAc的单stran Inclisiran。 | ||||
| GC70867 | AS-Inclisiran sodium | - | >95.00% | |
AS-Inclisiran sodium是Inclisiran的反义。 | ||||
| GC70952 | NADH-IN-1 | 1432445-15-2 | >99.00% | |
NADH-IN-1具有抑制NADH:泛醌氧化还原酶活性，IC50值为27 μM。 | ||||
| GC71006 | Cathepsin K inhibitor 6 | 325775-42-6 | >98.00% | |
Cathepsin K inhibitor 6（化合物19）是组织蛋白酶K（Cat K）的抑制剂，IC50为17nM。 | ||||
| GC71023 | CL-197 | 1030595-07-3 | >99.00% | |
CL-197是一种口服活性长效嘌呤抗HIV核苷逆转录酶抑制剂（NRTI）。 | ||||
| GC71026 | TP-030-2 | 2095514-84-2 | >98.00% | |
TP-030-2是RIPK1抑制剂（人Ki=0.43 nM；小鼠IC50=100 nM）。 | ||||
| GC71038 | TP0597850 | 2642181-22-2 | >99.00% | |
TP0597850是MMP2的选择性抑制剂（IC50=0.22 nM）。 | ||||
| GC71042 | 18β-Glycyrrhetyl-3-O-sulfate | 10251-38-4 | >98.00% | |
18β-Glycyrrhetyl-3-O-sulfate（甘草次酸3-O-（硫酸氢））是一种强效的2型11β-羟基类固醇脱氢酶（11β-HSD2）抑制剂，使用大鼠肾微粒体时IC50为0.10µM。 | ||||
| GC71043 | SPC5001 | - | 不显示 | |
SPC5001是一种与人PCSK9（前蛋白转化酶枯草杆菌蛋白酶/kexin 9型）mRNA互补的锁定核酸（LNA）修饰的反义寡核苷酸（ASO）。 | ||||
| GC71084 | Tyrosinase-IN-12 | 1860779-42-5 | >99.00% | |
Tyrosinase-IN-12是一种强效的非竞争性酪氨酸酶抑制剂，IC50值为49.33±2.64µM，Ki值为31.25±0.25µM。 | ||||
| GC71106 | MMP-9-IN-6 | 2241964-36-1 | >99.00% | |
MMP-9-IN-6(化合物3g)是一种MMP-9抑制剂，IC50值为50 μM，具有良好的抗溃疡作用。 | ||||
| GC71150 | O-Phospho-L-serine-13C3,15N | 2734706-69-3 | 不显示 | |
O-Phospho-L-serine-13C3,15N是13C和15N标记的O-磷酸-L-丝氨酸。 | ||||
| GC71198 | SEW84 | 259089-67-3 | 不显示 | |
SEW84是aha1刺激的Hsp90 (ASH) atp酶活性的抑制剂。 | ||||
| GC71210 | MTK458 | 2499962-58-0 | >99.00% | |
MTK458是一种口服活性脑渗透PINK1激活剂。 | ||||
| GC71214 | CZL55 | 667408-87-9 | >98.00% | |
CZL55是一种半胱天冬酶-1抑制剂，IC50值为24nM。 | ||||
| GC71251 | MMP-7-IN-2 | 2848717-49-5 | >99.00% | |
MMP-7-IN-2（化合物16）是MMP7的选择性抑制剂，IC50值为16nM。 | ||||
| GC71265 | Z16078526 | 852222-94-7 | >98.00% | |
Z16078526诱导内源性Ucp1表达，促进原代小鼠棕色脂肪细胞p38 MAPK磷酸化和脂肪分解。 | ||||