Metabolism
Metabolism(代谢)
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Metabolism 相关产品(3072)
- GC13554Deferoxamine mesylateCAS: 138-14-7纯度: >98.00% / >99.00% / >98.50% / >99.50%
Deferoxamine mesylate 是一种通过形成稳定的复合物来螯合铁的药物，该复合物可防止铁进入进一步的化学反应，并用于治疗输血依赖性贫血患者的慢性铁过载。
- GC136022-Hydroxypropyl-β-cyclodextrinCAS: 128446-35-5纯度: >99.00% / >99.50% / >98.00%
A cyclic oligosaccharide used to improve drug aqueous solubility
- GC13639Inolitazone dihydrochlorideCAS: 223132-38-5纯度: >98.00%
Inolitazone dihydrochloride (Efatutazone dihydrochloride) 是一种新型的高亲和力 PPARγ 激动剂，其生物活性依赖于 PPARγ，抑制生长的 IC50 为 0.8 nM。
- GC13670MethylmalonateCAS: 516-05-2纯度: >98.00%
A dicarboxylic acid and byproduct of propionate catabolism
- GC137847-EthoxyresorufinCAS: 5725-91-7纯度: >98.00%
A fluorogenic substrate for, and inhibitor of, CYP1A1
- GC13885Elesclomol (STA-4783)CAS: 488832-69-5纯度: >99.00% / >98.00%
Elesclomol（也称为 STA-4783）最初是在基于细胞的表型筛选中发现的促凋亡活性，是一种新型小分子，可通过快速产生活性氧 (ROS) 有效诱导癌细胞凋亡以及难以控制的氧化应激水平的诱导。
- GC13930N-(p-amylcinnamoyl) Anthranilic AcidCAS: 110683-10-8
A TRP channel blocker and PLA 2 inhibitor
- GC13941Cyclosporin ACAS: 59865-13-3纯度: >98.00% / >97.00% / >99.00%
Cyclosporin A是一种免疫抑制剂，其主要的三个靶点是亲环蛋白、钙调神经磷酸酶和转运蛋白，其抑制亲环蛋白A和钙调神经磷酸酶活性的IC 50 分别为360nM和5nM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC13519 | Navoximod | 1402837-78-8 | >99.00% | |
Navoximod (GDC-0919; NLG-919) 是一种有效的 IDO（吲哚胺-(2,3)-双加氧酶）通路抑制剂，Ki/EC50 为 7 nM/75 nM。 | ||||
| GC13538 | GSK180 | 1799725-26-0 | >99.00% | |
GSK180 是 kynurenine-3-monooxygenase (KMO) 的选择性、竞争性和强效抑制剂，KMO 是色氨酸代谢的关键酶 (IC50, ~6 nM)，但对色氨酸途径上的其他酶的活性可忽略不计。 | ||||
| GC13554 | Deferoxamine mesylate | 138-14-7 | >98.00% / >99.00% / >98.50% / >99.50% | |
Deferoxamine mesylate 是一种通过形成稳定的复合物来螯合铁的药物，该复合物可防止铁进入进一步的化学反应，并用于治疗输血依赖性贫血患者的慢性铁过载。 | ||||
| GC13585 | YM 26734 | 144337-18-8 | - | |
A group IIA sPLA 2 inhibitor | ||||
| GC13602 | 2-Hydroxypropyl-β-cyclodextrin | 128446-35-5 | >99.00% / >99.50% / >98.00% | |
A cyclic oligosaccharide used to improve drug aqueous solubility | ||||
| GC13608 | Lapatinib | 231277-92-2 | >99.50% | |
Lapatinib是一种口服的双重EGFR和HER2酪氨酸激酶抑制剂，对HER2阳性乳腺癌具有显著疗效。Lapatinib对纯化的EGFR和HER2的半数抑制浓度（IC₅₀）值分别为10.2nM和9.8nM。 | ||||
| GC13611 | CGP 3466B maleate | 200189-97-5 | >98.00% | |
A GAPDH ligand | ||||
| GC13620 | FIPI | 939055-18-2 | >99.00% | |
Potent inhibitor of PLD 1 and PLD 2 | ||||
| GC13639 | Inolitazone dihydrochloride | 223132-38-5 | >98.00% | |
Inolitazone dihydrochloride (Efatutazone dihydrochloride) 是一种新型的高亲和力 PPARγ 激动剂，其生物活性依赖于 PPARγ，抑制生长的 IC50 为 0.8 nM。 | ||||
| GC13670 | Methylmalonate | 516-05-2 | >98.00% | |
A dicarboxylic acid and byproduct of propionate catabolism | ||||
| GC13711 | Gabexate mesylate | 56974-61-9 | >98.00% | |
A serine protease inhibitor | ||||
| GC13751 | (3S,5S)-Atorvastatin (sodium salt) | 1428118-38-0 | - | |
An enantiomer of atorvastatin | ||||
| GC13760 | TC HSD 21 | 330203-01-5 | - | |
An inhibitor of 17β-HSD3 | ||||
| GC13763 | KT203 | 1402612-64-9 | >99.00% | |
A potent inhibitor of ABHD6 | ||||
| GC13776 | Piericidin A | 2738-64-9 | >95.00% | |
Piericidin A是一种天然的线粒体NADH-泛醌氧化还原酶（复合物I）抑制剂。 | ||||
| GC13784 | 7-Ethoxyresorufin | 5725-91-7 | >98.00% | |
A fluorogenic substrate for, and inhibitor of, CYP1A1 | ||||
| GC13829 | BADGE | 1675-54-3 | >85.00% | |
A PPARγ ligand that disrupts hormone-mediated cell differentiation | ||||
| GC13836 | 2,3-dihydrothieno-Thiadiazole Carboxylate | 152467-47-5 | - | |
Selective CYP450 inhibitor | ||||
| GC13885 | Elesclomol (STA-4783) | 488832-69-5 | >99.00% / >98.00% | |
Elesclomol（也称为 STA-4783）最初是在基于细胞的表型筛选中发现的促凋亡活性，是一种新型小分子，可通过快速产生活性氧 (ROS) 有效诱导癌细胞凋亡以及难以控制的氧化应激水平的诱导。 | ||||
| GC13930 | N-(p-amylcinnamoyl) Anthranilic Acid | 110683-10-8 | - | |
A TRP channel blocker and PLA 2 inhibitor | ||||
| GC13932 | Dorzolamide | 120279-96-1 | - | |
An Analytical Reference Standard | ||||
| GC13941 | Cyclosporin A | 59865-13-3 | >98.00% / >97.00% / >99.00% | |
Cyclosporin A是一种免疫抑制剂，其主要的三个靶点是亲环蛋白、钙调神经磷酸酶和转运蛋白，其抑制亲环蛋白A和钙调神经磷酸酶活性的IC 50 分别为360nM和5nM。 | ||||
| GC13948 | GPi 688 | 918902-32-6 | - | |
GPi 688 是一种有效且具有口服活性的糖原磷酸化酶 (GPa) 抑制剂，对人肝 GPa、大鼠肝 GPa 和人骨骼肌 GPa 的 IC50 分别为 19 nM、61 nM 和 12 nM。 | ||||
| GC13953 | Methyl α-Linolenyl Fluorophosphonate | - | - | |
A phospholipase inhibitor | ||||