Tyrosine Kinase
Tyrosine Kinase(酪氨酸激酶)
- Bcr-Abl(73)
- Ack1(3)
- Axl(6)
- ALK(64)
- BMX Kinase(3)
- Broad Spectrum Protein Kinase Inhibitor(10)
- c-FMS(42)
- c-Kit(58)
- c-MET(99)
- c-RET(7)
- CSF-1R(3)
- DDR1/DDR2 Receptor(1)
- EGFR(278)
- EphB4(1)
- FAK(39)
- FGFR(104)
- FLT3(97)
- HER2(15)
- IGF1R(34)
- Insulin Receptor(46)
- IRAK(32)
- ITK(10)
- Lck(1)
- LRRK2(25)
- PDGFR(113)
- PTKs/RTKs(10)
- Pyk2(8)
- ROR(41)
- Spleen Tyrosine Kinase (Syk)(33)
- Src(108)
- Tie-2 (4)
- Trk(43)
- VEGFR(200)
- Kinase
- Discoidin Domain Receptor(16)
- DYRK(35)
- Ephrin Receptor(13)
- RET(30)
- ROS(14)
- TAM Receptor(33)
- IGFBR(1)
- Others(55)
Tyrosine Kinase 相关产品(1402)
- GC37808Toceranib phosphateCAS: 874819-74-6纯度: >98.00%
A multi-targeted receptor tyrosine kinase inhibitor
- GC37857UNC2025 hydrochlorideCAS: 2070015-17-5纯度: >98.00%
An orally bioavailable inhibitor of Mer and Flt3
- GC38006β-HydroxyisovalerylshikoninCAS: 7415-78-3纯度: >99.50%
Beta-hydroxyisovalerylshikonin 是一种从Lithospermium radix 中分离出的天然产物，是一种有效的 PTK 抑制剂， 对 EGFR 和 v-Src 受体作用的 IC50 分别为 0.7 μM 和 1 μM。Beta-hydroxyisovalerylshikonin 对多种肿瘤细胞系均有抑制作用，能高效诱导 NCI-H522 和 DMS114 细胞的死亡。
- GC38081TheliatinibCAS: 1353644-70-8纯度: >99.50%
Theliatinib (HMPL-309) is a highly potent EGFR inhibitor with Ki value of 0.05 nM against the wild type EGFR and IC50 values of 3 nM and 22 nM against EGFR and EGFR T790M/L858R mutant. It demonstrats 50 fold greater selectivity for EGFR compared to 72 other kinases.
- GC38125Tyrphostin AG30CAS: 122520-79-0纯度: >98.50%
Tyrphostin AG30 (AG30), a potent and selective EGFR tyrosine kinase inhibitor, selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts.
- GC38180CyasteroneCAS: 17086-76-9纯度: >98.00%
Cyasterone，一种天然的 EGFR 抑制剂，主要分离自 Ajuga decumbens Thunb (Labiatae)。Cyasterone 通过诱导细胞凋亡 (apoptosis) 和细胞周期阻滞表现出抗增殖作用。 Cyasterone 可作为抗人类肿瘤的临床治疗性药物。
- GC38350Epertinib hydrochlorideCAS: 2071195-74-7纯度: >99.50%
Epertinib hydrochloride (S-222611 hydrochloride) is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4 with IC50 of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib hydrochloride (S-222611 hydrochloride) exhibits antitumor activity.
- GC38595c-Kit-IN-3CAS: 2363169-01-9
c-Kit-IN-3 (Compound 18) 是一种有效的 c-KIT 激酶抑制剂，IC50 为 4 nM。c-Kit-IN-3 在生化分析中显示出对 c-KIT 激酶和多种耐药突变体的强大效价，并具有很高的生物利用度。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC37808 | Toceranib phosphate | 874819-74-6 | >98.00% | |
A multi-targeted receptor tyrosine kinase inhibitor | ||||
| GC37849 | Tyrosine kinase inhibitor | 1021950-26-4 | >99.00% | |
本产品为酪氨酸激酶抑制剂。 | ||||
| GC37857 | UNC2025 hydrochloride | 2070015-17-5 | >98.00% | |
An orally bioavailable inhibitor of Mer and Flt3 | ||||
| GC37858 | UNC2541 | 1612782-86-1 | >99.00% | |
UNC2541 is a potent and specific inhibitor of Mer tyrosine kinase (MerTK) that binds in the MerTK ATP pocket with IC50 of 4.4 nM. UNC2541 inhibits phosphorylated MerTK (pMerTK) with EC50 of 510 nM. | ||||
| GC37886 | Vandetanib trifluoroacetate | 338992-53-3 | - | |
A multi-kinase inhibitor | ||||
| GC37933 | WHI-P180 hydrochloride | 153437-55-9 | - | |
A multi-kinase inhibitor | ||||
| GC37944 | XY101 | 2349368-16-5 | >98.50% | |
XY101 是一种有效选择性的、代谢稳定的口服 RORγ 反向激动剂，IC50 为 30 nM，Kd 为 380 nM。 | ||||
| GC38006 | β-Hydroxyisovalerylshikonin | 7415-78-3 | >99.50% | |
Beta-hydroxyisovalerylshikonin 是一种从Lithospermium radix 中分离出的天然产物，是一种有效的 PTK 抑制剂， 对 EGFR 和 v-Src 受体作用的 IC50 分别为 0.7 μM 和 1 μM。Beta-hydroxyisovalerylshikonin 对多种肿瘤细胞系均有抑制作用，能高效诱导 NCI-H522 和 DMS114 细胞的死亡。 | ||||
| GC38081 | Theliatinib | 1353644-70-8 | >99.50% | |
Theliatinib (HMPL-309) is a highly potent EGFR inhibitor with Ki value of 0.05 nM against the wild type EGFR and IC50 values of 3 nM and 22 nM against EGFR and EGFR T790M/L858R mutant. It demonstrats 50 fold greater selectivity for EGFR compared to 72 other kinases. | ||||
| GC38125 | Tyrphostin AG30 | 122520-79-0 | >98.50% | |
Tyrphostin AG30 (AG30), a potent and selective EGFR tyrosine kinase inhibitor, selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts. | ||||
| GC38180 | Cyasterone | 17086-76-9 | >98.00% | |
Cyasterone，一种天然的 EGFR 抑制剂，主要分离自 Ajuga decumbens Thunb (Labiatae)。Cyasterone 通过诱导细胞凋亡 (apoptosis) 和细胞周期阻滞表现出抗增殖作用。 Cyasterone 可作为抗人类肿瘤的临床治疗性药物。 | ||||
| GC38206 | WRG-28 | 1913291-02-7 | >99.00% | |
WRG-28 是选择性，细胞外作用的 DDR2 变构抑制剂，IC50 为 230 nM。WRG-28 通过受体的变构调节特异地抑制受体-配体相互作用。WRG-28 通过靶向 DDR2 抑制肿瘤侵袭和迁移，基质的肿瘤支持作用，并抑制肺中的转移性乳腺肿瘤细胞定植。 | ||||
| GC38330 | EHT 5372 | 1425945-60-3 | - | |
EHT 5372 是双特异性酪氨酸磷酸化调节酶 (DYRK) 的强效抑制剂，其 IC50 值分别为 0.22，0.28 nM。 | ||||
| GC38350 | Epertinib hydrochloride | 2071195-74-7 | >99.50% | |
Epertinib hydrochloride (S-222611 hydrochloride) is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4 with IC50 of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib hydrochloride (S-222611 hydrochloride) exhibits antitumor activity. | ||||
| GC38380 | Vorolanib | 1013920-15-4 | >99.50% / >98.00% | |
Vorolanib（X-82；CM082）是一种具口服活性的血管内皮生长因子受体（VEGFR）和血小板衍生生长因子受体（PDGFR）的多激酶双重抑制剂，IC 50 值分别为0.052μM、0.26 μM。 | ||||
| GC38402 | BI-4020 | 2664214-60-0 | >99.00% | |
BI-4020 is an orally active, non-covalent EGFR inhibitor with IC50 of 0.6 nM and 0.2 nM for EGFRdel19 T790M C797S as biomarker potency and anti-proliferation potency in BaF3 cells, respectively. | ||||
| GC38412 | Crotonoside | 1818-71-9 | >98.00% | |
Crotonoside是一种FLT3和HDAC3/6抑制剂，可用于研究急性髓系白血病(AML)。 | ||||
| GC38413 | Harmine hydrochloride | 343-27-1 | - | |
A unique regulator of PPARγ expression | ||||
| GC38437 | Fangchinoline | 436-77-1 | >99.50% | |
An alkaloid with diverse biological activities | ||||
| GC38519 | Ilorasertib hydrochloride | 1847485-91-9 | >98.50% | |
A multi-kinase inhibitor | ||||
| GC38575 | CP-547632 hydrochloride | 252003-71-7 | >98.00% | |
A potent inhibitor of VEGFR2 and bFGF | ||||
| GC38580 | RU-301 | 1110873-99-8 | >99.50% | |
RU-301 is a pan-TAM receptor (Axl, Tyro3 and Mertk) inhibitor that blocks the Axl receptor dimerization site with Kd of 12 μM and IC50 of 10 μM, respectively. | ||||
| GC38595 | c-Kit-IN-3 | 2363169-01-9 | - | |
c-Kit-IN-3 (Compound 18) 是一种有效的 c-KIT 激酶抑制剂，IC50 为 4 nM。c-Kit-IN-3 在生化分析中显示出对 c-KIT 激酶和多种耐药突变体的强大效价，并具有很高的生物利用度。 | ||||
| GC38630 | Lanraplenib succinate | 1800047-00-0 | >98.00% | |
A Syk inhibitor | ||||