GlpBio

TAM Receptor

TAM Receptor(TAM受体)

TAM receptors (Tyro3, Axl, and Mer) belong to a family of receptor tyrosine kinases that have important effects on hemostasis and inflammation. TAM receptors affect cell proliferation, survival, adhesion, and migration. TAM receptors can be activated by the vitamin K-dependent proteins Gas6 and protein S. Protein S is more commonly known as an important cofactor for protein C as well as a direct inhibitor of multiple coagulation factors.

The TAM receptors-Tyro3, Axl, and Mer-comprise a unique family of receptor tyrosine kinases, in that as a group they play no essential role in embryonic development. TAM receptor signaling plays an especially important role in the engulfment and phagocytic clearance of apoptotic cells (ACs) and membranes in adult tissues.

TAM Receptor 相关产品(32)

  • GC10408 structure
    GC104082-D08
    CAS: 144707-18-6
    纯度: >98.00%

    2-D08是一种合成黄酮和具有细胞通透性的小泛素样修饰蛋白（SUMO）抑制剂，也能抑制Axl靶点，IC 50 为0.49nM。

  • GC13500 structure
    GC13500UNC2881
    CAS: 1493764-08-1
    纯度: >99.50%

    A Mer kinase inhibitor

  • GC14214 structure
    GC14214BMS-777607
    CAS: 1025720-94-8
    纯度: >99.00%

    BMS-777607 是一种泛 TAM 抑制剂，对不同类型的癌症显示出抗肿瘤活性。

  • GC14218 structure
    GC14218TP-0903
    CAS: 1341200-45-0
    纯度: >99.50%

    An Axl kinase inhibitor

  • GC14241 structure
    GC14241LDC1267
    CAS: 1361030-48-9
    纯度: >98.00%

    A TAM family kinase inhibitor

  • GC14488 structure
    GC14488NPS-1034
    CAS: 1221713-92-3
    纯度: >98.00%

    A dual MET/AXL inhibitor

  • GC15779 structure
    GC15779Cabozantinib (XL184, BMS-907351)
    CAS: 849217-68-1
    纯度: >99.50%

    Cabozantinib (XL184,BMS-907351) 是一种新型 MET 和 VEGFR2 抑制剂，可同时抑制转移、血管生成和肿瘤生长。

  • GC17618 structure
    GC17618R428
    CAS: 1037624-75-1
    纯度: >99.50% / >99.00%

    R428作为一种Axl抑制剂,在纳摩尔浓度下阻断Axl在其C端对接位点Tyr821上的自动磷酸化。

  • GC17793 structure
    GC17793UNC2250
    CAS: 1493694-70-4
    纯度: >98.00%

    A selective Mer kinase inhibitor

  • GC18211 structure
    GC18211Ningetinib
    CAS: 1394820-69-9
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC19102 structure
    GC19102CEP-40783
    CAS: 1437321-24-8
    纯度: >99.00%

    A multi-kinase inhibitor

  • GC19166 structure
    GC19166Glesatinib hydrochloride
    CAS: 1123838-51-6
    纯度: >98.00%

    Glesatinib hydrochloride (MGCD265 hydrochloride) 是一种具有口服活性的强效 MET/SMO 双重抑制剂。 Glesatinib hydrochloride 是一种酪氨酸激酶抑制剂，可拮抗 P-糖蛋白 (P-gp) 介导的非小细胞肺癌 (NSCLC) 中的多药耐药 (MDR)。

  • GC19330 structure
    GC19330SGI-7079
    CAS: 1239875-86-5
    纯度: >99.50% / >98.00%

    An Axl kinase inhibitor

  • GC19482 structure
    GC19482Gilteritinib
    CAS: 1254053-43-4
    纯度: >99.00%

    Gilteritinib（ASP2215，Xospata）用于复发和/或难治性 AML (R/R AML)。

  • GC33271 structure
    GC33271R916562
    CAS: 1037798-41-6

    R916562是有效的和有选择性的Axl/VEGF-R2双重抑制剂,IC50值分别为136和24nM。

  • GC36135 structure
    GC36135Gilteritinib hemifumarate
    CAS: 1254053-84-3
    纯度: >99.50%

    A FLT3 inhibitor

  • GC36744 structure
    GC36744Ningetinib Tosylate
    CAS: 1394820-77-9
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC37733 structure
    GC37733TAM-IN-2
    CAS: 2135642-56-5
    纯度: >99.50%

    TAM-IN-2 是专利 US 20170275290 A1 中提到的 TAM 抑制剂，吡咯并三嗪化合物 0904。

  • GC37858 structure
    GC37858UNC2541
    CAS: 1612782-86-1
    纯度: >99.00%

    UNC2541 is a potent and specific inhibitor of Mer tyrosine kinase (MerTK) that binds in the MerTK ATP pocket with IC50 of 4.4 nM. UNC2541 inhibits phosphorylated MerTK (pMerTK) with EC50 of 510 nM.

  • GC38580 structure
    GC38580RU-301
    CAS: 1110873-99-8
    纯度: >99.50%

    RU-301 is a pan-TAM receptor (Axl, Tyro3 and Mertk) inhibitor that blocks the Axl receptor dimerization site with Kd of 12 μM and IC50 of 10 μM, respectively.

  • GC62266 structure
    GC62266XL092
    CAS: 2367004-54-2
    纯度: >99.50%

    XL092 (JUN04542) is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER, with IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays, respectively.

  • GC62516 structure
    GC62516UNC5293
    CAS: 2226789-82-6
    纯度: >99.00%

    UNC5293 是一种 MERTK 选择性的有效抑制剂 (Ki=190 pM)。UNC5293 抑制 MERTK (IC50=0.9 nM)，对 Axl、Tyro3 和 Flt3 更具选择性。UNC5293 表现出优异的小鼠药代动力学特性，并可以被用于骨髓白血病研究。

  • GC62597 structure
    GC62597DS-1205b free base
    CAS: 1855860-24-0
    纯度: >99.50%

    DS-1205b free base 是一种有效和选择性的 AXL 激酶抑制剂，IC50 值为 1.3 nM。DS-1205b free base 还可以抑制 MER，MET 和 TRKA，IC50 值分别为 63、104 和 407 nM。 DS-1205b free base 可以抑制细胞迁移和肿瘤生长。

  • GC64071 structure
    GC64071AZ14145845

    AZ14145845 是一种具有体内药效的高选择性I1/2型Mer/Axl双特异性激酶抑制剂。