GlpBio

Ningetinib Tosylate

目录号: GC36744纯度: >99.50%同义词: 对甲苯磺酸宁格替尼
A multi-kinase inhibitor
Ningetinib Tosylate
Cas No.: 1394820-77-9
规格价格库存数量操作
2mg¥485.00现货
1
5mg¥765.00现货
1
10mg¥1,080.00现货
1
25mg¥2,500.00现货
1
50mg¥3,780.00现货
1
100mg¥6,480.00现货
1
200mg¥0.01现货
1
500mg¥0.01现货
1
Free Sample (0.1-0.5 mg)¥0.01现货
1
10mM (in 1mL DMSO)¥1,227.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Ningetinib is a multi-kinase inhibitor that inhibits c-Met, VEGFR2/KDR, and Axl (IC50s = 19, 37, and 11 nM, respectively).1 In vivo, ningetinib (20 mg/kg) inhibits tumor growth in MKN45, Caki-1, NCI-H441, Huh-7, U87MG, and MDA-MB-231 mouse xenograft models by 53-97%.

1.Xi, N.Substituted quinoline compounds and methods of useUS20120219522A1(2012)

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
1394820-77-9
同义词
对甲苯磺酸宁格替尼
SMILES
CC1=CC=C(S(=O)(O)=O)C=C1.CC2=C(C(NC3=CC(F)=C(OC4=CC=NC5=C4C=CC(OCC(C)(O)C)=C5)C=C3)=O)C(N(C6=CC=CC=C6)N2C)=O
分子式
C38H37FN4O8S
分子量
728.79 g/mol
溶解性
DMSO: 33.33 mg/mL (45.73 mM); Water: < 0.1 mg/mL (insoluble)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol