Crotonoside is a FLT3 and HDAC3/6 inhibitor that can be used to study acute myeloid leukemia (AML)[1].
Crotonoside (50μM, 24h) induced late apoptosis in about 50% AML cell line MV4-11[1]. Crotonoside (7.5, 15, or 30μM; 48h) significantly induced AML cell apoptosis in a dose-dependent manner[2].
Crotonoside (25, 50, or 100mg/kg; 20 days; i.p.) ameliorated the severity of collagen-induced arthritis (CIA) in mice[3]. Compared with the rabbits in the normal saline (NS) group, the group given Crotonoside (4.5mg/kg, intravenous injection) effectively prolonged the time of aconitine-induced arrhythmias and significantly reduced the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF)[4].
References:
[1] Li YZ, Yu S, Yan PA, et al. Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6. Oncotarget. 2017 Nov 11;8(61):103087.
[2] Ma C, Liu P, Cui S, et al. The identification of APOBEC3G as a potential prognostic biomarker in acute myeloid leukemia and a possible drug target for crotonoside. Molecules. 2022 Sep 7;27(18):5804.
[3] Lin SC, Lin CC, Li S, et al. Alleviation of collagen-induced arthritis by crotonoside through modulation of dendritic cell differentiation and activation. Plants. 2020 Nov 10;9(11):1535.
[4] Liu Z, Jia Y, Song L, et al. Antiarrhythmic effect of crotonoside by regulating sodium and calcium channels in rabbit ventricular myocytes. Life sciences. 2020 Mar 1;244:117333.
Crotonoside是一种FLT3和HDAC3/6抑制剂，可用于研究急性髓系白血病(AML)[1]。
Crotonoside（50μM，24小时）诱导约50%的AML细胞株MV4-11发生晚期凋亡[1]。Crotonoside（7.5、15或30μM，48小时）以剂量依赖性方式显著诱导AML细胞凋亡[2]。
Crotonoside（25、50或100 mg/kg，20天，腹腔注射）可改善小鼠胶原诱导性关节炎（CIA）的严重程度[3]。与生理盐水（NS）组的兔相比，Crotonoside（4.5mg/kg，静脉注射）组能有效延长Crotonoside诱发的心律失常时间，并明显降低室性心动过速（VT）和心室颤动（VF）的发生率[4]。