HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

HDAC 相关产品(175)

GC10322 Tubastatin A HCl
CAS: 1310693-92-5
纯度: >98.00%
A potent HDAC6 inhibitor
GC10423 RG2833
CAS: 1215493-56-3
纯度: >98.00%
An HDAC inhibitor
GC10839 Tubastatin A
CAS: 1252003-15-8
纯度: >98.00%
Tubastatin A 是一种有效的选择性 HDAC6 抑制剂，IC 50 值为 15 nM。并且Tubastatin A也是一种新型GPX4抑制剂，Tubastatin A 直接与 GPX4 结合，诱导乳腺癌细胞铁死亡。
GC11095 Pyroxamide
CAS: 382180-17-8
纯度: >99.50%
A HDAC inhibitor
GC11334 Romidepsin (FK228, depsipeptide)
CAS: 128517-07-7
纯度: >99.50%
Romidepsin (FK228, depsipeptide)是一种有效且选择性的组蛋白去乙酰化酶（HDAC）抑制剂，抑制HDAC1，HDAC2，HDAC4和HDAC6的IC 50 值分别为36nM，47nM，510nM和1.4μM。
GC11424 Valproic acid
CAS: 99-66-1
纯度: >98.00%
A class I HDAC inhibitor
GC11625 Entinostat (MS-275,SNDX-275)
CAS: 209783-80-2
纯度: >99.00% / >98.00%
Entinostat (MS-275,SNDX-275)是一种强效的、可口服的组蛋白去乙酰化酶（HDACs）抑制剂，对HDAC1和HDAC3的IC₅₀分别为0.368μM和0.501μM，但对HDAC8的抑制作用相对较弱。
GC11975 CHAPS
CAS: 75621-03-3
纯度: >99.00%
CHAPS 是胆酸的衍生物，是一种用于溶解膜蛋白的两性离子去污剂。
GC12019 TCS HDAC6 20b
CAS: 956154-63-5
An HDAC6 inhibitor
GC12115 CUDC-907
CAS: 1339928-25-4
纯度: >99.50%
CUDC 是一种口服生物可利用的小分子 PI3K 和 HDAC 双重抑制剂，作用于 PI3K α 和 HDAC1 / 2 / 3 / 10，IC50 分别为 19 nm 和 1.7 nm / 5 nm / 1.8 nm / 2.8 nm .在 WSU DLCL2 细胞中评估了双功能 HDAC 和 PI3K 抑制剂 CUDC-907 的抗肿瘤活性。
GC12257 Panobinostat (LBH589)
CAS: 404950-80-7
纯度: >99.00%
Panobinostat (LBH589)是一种强效，且具有口服活性和抗肿瘤活性的广谱组蛋白去乙酰化酶（HDAC）抑制剂，IC 50 值为5nM。
GC12961 Apicidin
CAS: 183506-66-3
纯度: >98.00% / >90.00%
A cell-permeable HDAC inhibitor
GC13055 Mocetinostat (MGCD0103, MG0103)
CAS: 726169-73-9
纯度: >99.00%
An orally available HDAC inhibitor
GC13237 LMK 235
CAS: 1418033-25-6
纯度: >99.50%
A selective inhibitor of HDAC4 and HDAC5
GC13408 CI994 (Tacedinaline)
CAS: 112522-64-2
纯度: >98.00%
An inhibitor of HDAC1, -2, and -3
GC13435 KD 5170
CAS: 940943-37-3
An inhibitor of class I and II HDACs
GC13591 TC-H 106
CAS: 937039-45-7
纯度: >98.00%
A tight-binding inhibitor of class I HDACs
GC13706 Droxinostat
CAS: 99873-43-5
纯度: >99.50%
An inhibitor of HDAC3, HDAC6, and HDAC8
GC14243 Resminostat hydrochloride
CAS: 1187075-34-8
纯度: >99.00%
An orally bioavailable HDAC inhibitor
GC14285 RGFP966
CAS: 1357389-11-7
纯度: >99.50% / >98.00%
RGFP966是一种N-(o-aminophenyl)carboxamide HDAC抑制剂，对HDAC3的IC50为0.08 μM，是一类针对HDAC3的慢开/慢关竞争性紧密结合抑制剂。
GC14340 Tasquinimod
CAS: 254964-60-8
纯度: >98.00%
Tasquinimod是一种具有口服活性的组蛋白去乙酰化酶4（HDAC4）和S100 钙结合蛋白A9（S100A9）抑制剂。
GC14590 AR-42 (OSU-HDAC42)
CAS: 935881-37-1
HDAC inhibitor,novel and potent
GC14682 PCI-24781 (CRA-024781)
CAS: 783355-60-2
纯度: >98.50%
An HDAC inhibitor
GC14998 Rocilinostat (ACY-1215)
CAS: 1316214-52-4
纯度: >98.00%
A selective inhibitor of HDAC6

分类产品列表
货号	产品名称	CAS号	纯度
GC10322	Tubastatin A HCl	1310693-92-5	>98.00%
GC10322	A potent HDAC6 inhibitor
GC10423	RG2833	1215493-56-3	>98.00%
GC10423	An HDAC inhibitor
GC10839	Tubastatin A	1252003-15-8	>98.00%
GC10839	Tubastatin A 是一种有效的选择性 HDAC6 抑制剂，IC 50 值为 15 nM。并且Tubastatin A也是一种新型GPX4抑制剂，Tubastatin A 直接与 GPX4 结合，诱导乳腺癌细胞铁死亡。
GC11095	Pyroxamide	382180-17-8	>99.50%
GC11095	A HDAC inhibitor
GC11334	Romidepsin (FK228, depsipeptide)	128517-07-7	>99.50%
GC11334	Romidepsin (FK228, depsipeptide)是一种有效且选择性的组蛋白去乙酰化酶（HDAC）抑制剂，抑制HDAC1，HDAC2，HDAC4和HDAC6的IC 50 值分别为36nM，47nM，510nM和1.4μM。
GC11424	Valproic acid	99-66-1	>98.00%
GC11424	A class I HDAC inhibitor
GC11625	Entinostat (MS-275,SNDX-275)	209783-80-2	>99.00% / >98.00%
GC11625	Entinostat (MS-275,SNDX-275)是一种强效的、可口服的组蛋白去乙酰化酶（HDACs）抑制剂，对HDAC1和HDAC3的IC₅₀分别为0.368μM和0.501μM，但对HDAC8的抑制作用相对较弱。
GC11975	CHAPS	75621-03-3	>99.00%
GC11975	CHAPS 是胆酸的衍生物，是一种用于溶解膜蛋白的两性离子去污剂。
GC12019	TCS HDAC6 20b	956154-63-5	-
GC12019	An HDAC6 inhibitor
GC12115	CUDC-907	1339928-25-4	>99.50%
GC12115	CUDC 是一种口服生物可利用的小分子 PI3K 和 HDAC 双重抑制剂，作用于 PI3K α 和 HDAC1 / 2 / 3 / 10，IC50 分别为 19 nm 和 1.7 nm / 5 nm / 1.8 nm / 2.8 nm .在 WSU DLCL2 细胞中评估了双功能 HDAC 和 PI3K 抑制剂 CUDC-907 的抗肿瘤活性。
GC12257	Panobinostat (LBH589)	404950-80-7	>99.00%
GC12257	Panobinostat (LBH589)是一种强效，且具有口服活性和抗肿瘤活性的广谱组蛋白去乙酰化酶（HDAC）抑制剂，IC 50 值为5nM。
GC12961	Apicidin	183506-66-3	>98.00% / >90.00%
GC12961	A cell-permeable HDAC inhibitor
GC13055	Mocetinostat (MGCD0103, MG0103)	726169-73-9	>99.00%
GC13055	An orally available HDAC inhibitor
GC13237	LMK 235	1418033-25-6	>99.50%
GC13237	A selective inhibitor of HDAC4 and HDAC5
GC13408	CI994 (Tacedinaline)	112522-64-2	>98.00%
GC13408	An inhibitor of HDAC1, -2, and -3
GC13435	KD 5170	940943-37-3	-
GC13435	An inhibitor of class I and II HDACs
GC13591	TC-H 106	937039-45-7	>98.00%
GC13591	A tight-binding inhibitor of class I HDACs
GC13706	Droxinostat	99873-43-5	>99.50%
GC13706	An inhibitor of HDAC3, HDAC6, and HDAC8
GC14243	Resminostat hydrochloride	1187075-34-8	>99.00%
GC14243	An orally bioavailable HDAC inhibitor
GC14285	RGFP966	1357389-11-7	>99.50% / >98.00%
GC14285	RGFP966是一种N-(o-aminophenyl)carboxamide HDAC抑制剂，对HDAC3的IC50为0.08 μM，是一类针对HDAC3的慢开/慢关竞争性紧密结合抑制剂。
GC14340	Tasquinimod	254964-60-8	>98.00%
GC14340	Tasquinimod是一种具有口服活性的组蛋白去乙酰化酶4（HDAC4）和S100 钙结合蛋白A9（S100A9）抑制剂。
GC14590	AR-42 (OSU-HDAC42)	935881-37-1	-
GC14590	HDAC inhibitor,novel and potent
GC14682	PCI-24781 (CRA-024781)	783355-60-2	>98.50%
GC14682	An HDAC inhibitor
GC14998	Rocilinostat (ACY-1215)	1316214-52-4	>98.00%
GC14998	A selective inhibitor of HDAC6