GlpBio

HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

HDAC 相关产品(175)

  • GC15002 structure
    GC15002Sodium Phenylbutyrate
    CAS: 1716-12-7
    纯度: >99.50%

    Sodium Phenylbutyrate是一种组蛋白去乙酰化酶（HDAC）抑制剂。

  • GC15040 structure
    GC15040NSC 3852
    CAS: 3565-26-2

    A tumor cell differentiating agent

  • GC15114 structure
    GC15114LAQ824 (NVP-LAQ824,Dacinostat)
    CAS: 404951-53-7
    纯度: >98.00%

    LAQ824 (NVP-LAQ824,Dacinostat)是一种新型、高效的组蛋白去乙酰化酶（HDAC）抑制剂，IC 50 为32nM。

  • GC15315 structure
    GC15315Scriptaid
    CAS: 287383-59-9
    纯度: >98.50%

    HDAC inhibitor

  • GC15476 structure
    GC15476JNJ-26481585
    CAS: 875320-29-9
    纯度: >98.00%

    A pan-HDAC inhibitor

  • GC15526 structure
    GC15526Trichostatin A (TSA)
    CAS: 58880-19-6
    纯度: >99.50% / >95.00% / >98.00%

    Trichostatin A (TSA) 是一种有效的组蛋白脱乙酰酶 (HDAC) 抑制剂和抗真菌抗生素，对 HDAC 的 IC50 值为 1.8 nM，具有抑制细胞生长和诱导细胞分化。

  • GC15536 structure
    GC15536NCH 51
    CAS: 848354-66-5
    纯度: >99.50%

    An HDAC inhibitor

  • GC15794 structure
    GC15794Valproic acid sodium salt (Sodium valproate)
    CAS: 1069-66-5
    纯度: >98.00%

    Valproic acid sodium salt (Sodium valproate)（VPA）是一种具有口服活性的组蛋白脱乙酰酶 （HDAC）抑制剂，IC 50 值为1.5mM，抑制HDAC1的IC 50 值为400μM，同时可诱导HDAC2的降解。

  • GC15830 structure
    GC15830Daminozide
    CAS: 1596-84-5
    纯度: >98.00%

    Selective inhibitor of KDM2/7 histone demethylases

  • GC15879 structure
    GC15879Resminostat (RAS2410)
    CAS: 864814-88-0

    Resminostat (RAS2410) (RAS2410; 4SC-201) 是一种有效的 HDAC1、HDAC3 和 HDAC6 抑制剂，平均 IC50 值分别为 42.5、50.1、71.8 nM，对 HDAC8 的活性较低，IC50 为 877 nM .

  • GC15962 structure
    GC15962Belinostat (PXD101)
    CAS: 414864-00-9

    Belinostat (PXD101) 是 HeLa 细胞提取物中组蛋白脱乙酰酶 (HDAC) 活性的新型异羟肟酸型抑制剂，IC50 为 27 nM 。

  • GC15965 structure
    GC15965MC1568
    CAS: 852475-26-4

    A selective class IIa HDAC inhibitor

  • GC16008 structure
    GC16008CUDC-101
    CAS: 1012054-59-9
    纯度: >99.00%

    A multi-target inhibitor of HDACs, EGFR, and HER2

  • GC16143 structure
    GC16143Varenicline Hydrochloride
    CAS: 230615-23-3
    纯度: >98.50%

    Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。

  • GC16386 structure
    GC16386Tubacin
    CAS: 537049-40-4
    纯度: >95.00%

    Tubacin (tubulin acetylation inducer)是一种选择性抑制组蛋白去乙酰化酶6 (HDAC6)，诱导α-微管蛋白乙酰化的小分子，IC50为0.004µM。

  • GC16456 structure
    GC16456M344
    CAS: 251456-60-7
    纯度: >98.00%

    M344是一种组蛋白去乙酰化酶（HDAC）抑制剂，其IC 50 值为100nM。

  • GC16734 structure
    GC16734Pracinostat (SB939)
    CAS: 929016-96-6
    纯度: >99.50%

    A pan-HDAC inhibitor

  • GC17390 structure
    GC17390Vorinostat (SAHA, MK0683)
    CAS: 149647-78-9
    纯度: >98.00% / >99.00%

    An HDAC inhibitor

  • GC17703 structure
    GC17703TMP269
    CAS: 1314890-29-3
    纯度: >98.00%

    A selective class IIa HDAC inhibitor

  • GC17836 structure
    GC17836ITF2357 (Givinostat)
    CAS: 732302-99-7
    纯度: >98.00%

    HDAC inhibitor with anti-inflammatory and antineoplastic activities

  • GC18008 structure
    GC18008PCI-34051
    CAS: 950762-95-5
    纯度: >99.00%

    PCI-34051是一种高效且选择性的HDAC8抑制剂，其IC 50 为10nM。

  • GN10357 structure
    GN10357Parthenolide
    CAS: 20554-84-1
    纯度: >99.50% / >97.00%

    Parthenolide是一种NF-κB抑制剂，对Eca109、KYSE-510、SiHa和MCF-7细胞48h的IC 50 值分别约为10.3、13.3、8.42和9.54µM。

  • GA20481 structure
    GA20481Ac-Arg-Gly-Lys(Ac)-AMC
    CAS: 660846-97-9
    纯度: >98.00%

    Ac-Arg-Gly-Lys(Ac)-AMC 是 HDAC 的底物。

  • GA20605 structure
    GA20605Ac-Lys-AMC
    CAS: 156661-42-6
    纯度: >98.00%

    Ac-Lys-AMC（己酰胺），也称为 MAL，是组蛋白去乙酰化酶 HDAC 的荧光底物。