GlpBio

HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

HDAC 相关产品(175)

  • GC73828 structure
    GC73828F-SAHA
    CAS: 149648-08-8
    纯度: >99.00%

    F-SAHA是HDAC抑制剂（HDACi），其18F标记的衍生物可用于肿瘤成像研究。

  • GC73848 structure
    GC73848Martinostat hydrochloride
    纯度: >99.00%

    Martinostat hydrochloride是HDAC的抑制剂，可以用放射性核素标记用于诊断应用。

  • GC73925 structure
    GC73925YSR734
    CAS: 3032969-58-4
    纯度: >98.00%

    YSR734（化合物21）是一种共价HDAC抑制剂，对HDAC1、HDAC2和HDAC3的IC50值分别为110 nM、154 nM和143 nM。

  • GC73933 structure
    GC73933CM-1758
    CAS: 2256079-39-5
    纯度: >98.00%

    CM-1758是一种组蛋白去乙酰化酶（HDAC）抑制剂。

  • GC73944 structure
    GC73944SE-7552
    CAS: 2243575-79-1
    纯度: >98.00%

    SE-7552是一种2-（二氟金属）-1,3,4-恶二唑（DFMO）衍生物，是一种具有口服活性、高选择性、非氨基甲酸酯类HDAC6抑制剂，IC50为33 nM。

  • GC74007 structure
    GC74007SelSA
    CAS: 1225038-92-5
    纯度: >99.00%

    SelSA是一种选择性的口服活性组蛋白去乙酰化酶6 （HDAC6）抑制剂，IC50为56.9 nM。

  • GC74062 structure
    GC74062LSD1/HDAC6-IN-2
    CAS: 2982787-50-6
    纯度: >99.00%

    LSD1/HDAC6-IN-2（JBI-802）是一种口服活性LSD1/HDAC6/MOA-A抑制剂，IC50值分别为5 nM、11 nM和5 nM。