HDAC
HDAC(组蛋白去乙酰化酶)
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
HDAC 相关产品(175)
- GC25139Biphenyl-4-sulfonyl chlorideCAS: 1623-93-4
Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
- GC30763Benzenebutyric acid (4-Phenylbutyric acid)CAS: 1821-12-1纯度: >98.00% / >99.00%
4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.
- GC31511Sinapinic acid (Sinapic acid)CAS: 530-59-6纯度: >99.50%
A phenylpropanoid hydroxycinnamic acid with diverse biological activities
- GC33050Givinostat (ITF-2357)CAS: 497833-27-9
HDAC inhibitor with anti- inflammatory and antineoplastic activities
- GC33115Pomiferin (NSC 5113)CAS: 572-03-2纯度: >98.00%
Pomiferin (NSC 5113) (NSC 5113) 作为 HDAC 的潜在抑制剂，其 IC50 为 1.05 μM，并且还有效抑制 mTOR (IC50, 6.2 μM)。
- GC33159Givinostat hydrochloride (ITF-2357 hydrochloride)CAS: 199657-29-9
HDAC inhibitor with anti- inflammatory and antineoplastic activities
- GC33290Remetinostat (SHP-141)CAS: 946150-57-8纯度: >98.00%
Remetinostat (SHP-141) (SHP-141) 是一种基于异羟肟酸的组蛋白脱乙酰酶 (HDAC) 抑制剂，正在开发用于治疗皮肤 T 细胞淋巴瘤。
- GC33317HDAC6-IN-1CAS: 1815580-06-3纯度: >99.00%
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.
- GC35551BRD 4354 ditrifluoroacetate
BRD 4354 (ditrifluoroacetate) 是 HDAC5 和 HDAC9 抑制剂，其 IC50 值分别为 0.85，1.88 μM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC19189 | HDAC8-IN-1 | 1417997-93-3 | >99.50% | |
An HDAC8 inhibitor | ||||
| GC19190 | HDAC-IN-4 | 934828-12-3 | >99.00% / >99.50% | |
An HDAC inhibitor | ||||
| GC19337 | SR-4370 | 1816294-67-3 | >98.00% | |
An HDAC3 inhibitor | ||||
| GC19360 | TMP195 | 1314891-22-9 | >99.50% | |
TMP195 是一种有效的选择性 IIa 类 HDAC 抑制剂，对 HDAC4、HDAC5、HDAC7 和 HDAC9 的 IC50 分别为 59 nM、60 nM、26 nM 和 15 nM。 | ||||
| GC19406 | TH34 | 2196203-96-8 | >98.00% | |
TH34 是一种 HDAC6/8/10 抑制剂，IC50 分别为 4.6 μM、1.9 μM 和 7.7 μM，对 HDAC1/2/3 具有高选择性。 | ||||
| GC25139 | Biphenyl-4-sulfonyl chloride | 1623-93-4 | - | |
Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. | ||||
| GC25552 | KT-531 | 2490284-18-7 | - | |
KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms. | ||||
| GC30526 | ACY-957 | 1609389-52-7 | >99.50% | |
ACY-957是一种选择性的HDAC1和HDAC2抑制剂，对HDAC1/2/3的IC50值分别为7nM，18nM和1300nM，对HDAC4/5/6/7/8/9无作用。 | ||||
| GC30763 | Benzenebutyric acid (4-Phenylbutyric acid) | 1821-12-1 | >98.00% / >99.00% | |
4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models. | ||||
| GC30782 | ACY-775 | 1375466-18-4 | >99.50% | |
An HDAC6 inhibitor | ||||
| GC31511 | Sinapinic acid (Sinapic acid) | 530-59-6 | >99.50% | |
A phenylpropanoid hydroxycinnamic acid with diverse biological activities | ||||
| GC32565 | CRA-026440 | 847460-34-8 | - | |
CRA-026440 是一种有效的广谱 HDAC 抑制剂。 | ||||
| GC32964 | NKL 22 | 537034-15-4 | - | |
A selective HDAC1/3 inhibitor | ||||
| GC33050 | Givinostat (ITF-2357) | 497833-27-9 | - | |
HDAC inhibitor with anti- inflammatory and antineoplastic activities | ||||
| GC33115 | Pomiferin (NSC 5113) | 572-03-2 | >98.00% | |
Pomiferin (NSC 5113) (NSC 5113) 作为 HDAC 的潜在抑制剂，其 IC50 为 1.05 μM，并且还有效抑制 mTOR (IC50, 6.2 μM)。 | ||||
| GC33159 | Givinostat hydrochloride (ITF-2357 hydrochloride) | 199657-29-9 | - | |
HDAC inhibitor with anti- inflammatory and antineoplastic activities | ||||
| GC33290 | Remetinostat (SHP-141) | 946150-57-8 | >98.00% | |
Remetinostat (SHP-141) (SHP-141) 是一种基于异羟肟酸的组蛋白脱乙酰酶 (HDAC) 抑制剂，正在开发用于治疗皮肤 T 细胞淋巴瘤。 | ||||
| GC33317 | HDAC6-IN-1 | 1815580-06-3 | >99.00% | |
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability. | ||||
| GC33331 | BRD 4354 | 315698-07-8 | >98.00% | |
BRD4354是HDAC5和HDAC9适度抑制剂，其IC50值分别为0.85，1.88μM。 | ||||
| GC33395 | HDAC-IN-5 | 1314890-51-1 | - | |
HDAC-IN-5是组蛋白去乙酰化酶(HDAC)的一个抑制剂。 | ||||
| GC34165 | Corin | 1808113-09-8 | >98.00% | |
Corin是组氨酸赖氨酸特异性去甲基化酶(LSD1)和组氨酸脱乙酰化酶(HDAC)的双重抑制剂，其对LSD1的Ki(inact)值为110nM，对HDAC1的IC50值为147nM。 | ||||
| GC34458 | ACY-1083 | 1708113-43-2 | >98.50% | |
ACY-1083是一种可渗透脑的选择性HDAC6抑制剂，IC50为3nM，ACY-1083对HDAC6的选择性比其他类别的HDAC亚型高260倍。ACY-1083可有效逆转化疗引起的周围神经病变。 | ||||
| GC34629 | J22352 | 2252395-44-9 | >99.50% | |
J22352是一种具有类似靶向嵌合体蛋白水解(PROTAC)特性、高度选择性HDAC6抑制剂，其IC50值为4.7nM，J22352通过抑制胶质母细胞瘤自噬、诱发抗肿瘤免疫反应来促进HDAC6降解和诱导抗癌效果，并通过降低PD-L1的免疫抑制活性，使宿主抗肿瘤活性恢复。 | ||||
| GC35551 | BRD 4354 ditrifluoroacetate | - | - | |
BRD 4354 (ditrifluoroacetate) 是 HDAC5 和 HDAC9 抑制剂，其 IC50 值分别为 0.85，1.88 μM。 | ||||