GlpBio

HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

HDAC 相关产品(175)

  • GC10417 structure
    GC10417ACY-241
    CAS: 1316215-12-9
    纯度: >98.50%

    An HDAC6 inhibitor

  • GC11360 structure
    GC11360ORY-1001
    CAS: 1431326-61-2

    An LSD1 inhibitor

  • GC11574 structure
    GC11574HPOB
    CAS: 1429651-50-2

    A potent and selective inhibitor of HDAC6

  • GC11949 structure
    GC11949MI-192
    CAS: 1415340-63-4

    A selective HDAC2/3 Inhibitor

  • GC12074 structure
    GC12074BG45
    CAS: 926259-99-6
    纯度: >99.50%

    A selective HDAC3 inhibitor

  • GC12334 structure
    GC12334HNHA
    CAS: 926908-04-5

    HDAC inhibitor

  • GC12484 structure
    GC12484BRD73954
    CAS: 1440209-96-0
    纯度: >98.00%

    A dual inhibitor of HDAC6 and HDAC8

  • GC12667 structure
    GC126674SC-202
    CAS: 1186222-89-8
    纯度: >99.50%

    An HDAC1-3 and KDM1A inhibitor

  • GC12822 structure
    GC12822BML-210(CAY10433)
    CAS: 537034-17-6

    A potent, synthetic HDAC inhibitor

  • GC12971 structure
    GC12971CAY10603
    CAS: 1045792-66-2
    纯度: >99.50%

    An exceptionally potent inhibitor of HDAC6

  • GC13764 structure
    GC13764Nexturastat A
    CAS: 1403783-31-2
    纯度: >98.00%

    A potent, cell-permeable HDAC6 inhibitor

  • GC13925 structure
    GC13925Nullscript
    CAS: 300816-11-9
    纯度: >98.00%

    A negative control for scriptaid

  • GC14016 structure
    GC14016Sulforaphane
    CAS: 4478-93-7
    纯度: >98.00% / >99.00% / >97.00%

    萝卜硫素 (SFN) 称为 [1-isothiocyanato-4-(methylsulfinyl)butane]。

  • GC14058 structure
    GC14058CBHA
    CAS: 174664-65-4
    纯度: >98.00%

    Inhibitor of histone deacetylases

  • GC14367 structure
    GC14367UF 010
    CAS: 537672-41-6
    纯度: >99.50%

    A class I HDAC inhibitor

  • GC14439 structure
    GC14439Santacruzamate A (CAY10683)
    CAS: 1477949-42-0
    纯度: >99.00%

    Santacruzamate A (CAY10683)是一种天然氨基甲酸酯衍生物，可抑制HDAC2和HDAC6活性，IC 50 值分别为0.119nM和434nM。

  • GC14597 structure
    GC14597ITSA-1 (ITSA1)
    CAS: 200626-61-5
    纯度: >98.00%

    ITSA-1 (ITSA1)是一种组蛋白去乙酰化酶（HDAC）激活剂，可以防止动脉层流剪切力诱导的内皮细胞脱落，并降低血管内皮细胞（vECs）中VCAM-1的表达。

  • GC15410 structure
    GC15410Bufexamac
    CAS: 2438-72-4
    纯度: >98.00%

    An NSAID and a class IIb HDAC inhibitor

  • GC15857 structure
    GC15857Sodium butyrate
    CAS: 156-54-7
    纯度: >99.00%

    A short-chain fatty acid and HDAC inhibitor

  • GC17472 structure
    GC17472Oxamflatin
    CAS: 151720-43-3
    纯度: >98.00%

    Inhibitor of histone deacetylases

  • GC18206 structure
    GC18206WT161
    CAS: 1206731-57-8
    纯度: >98.50%

    A potent inhibitor of HDAC6

  • GC18402 structure
    GC18402GSK3117391
    CAS: 1018673-42-1
    纯度: >98.50%

    An HDAC inhibitor

  • GC19020 structure
    GC19020ACY-738
    CAS: 1375465-91-0
    纯度: >98.50%

    ACY-738是一种具有口服活性的选择性组蛋白去乙酰化酶6（HDAC6；IC 50 =1.7nM）抑制剂。

  • GC19129 structure
    GC19129EDO-S101
    CAS: 1236199-60-2
    纯度: >98.00%

    An HDAC inhibitor and DNA alkylating agent