Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a histone deacetylase inhibitor (HDACi), that plays key roles in epigenetic or non-epigenetic regulation, inducing growth arrest, differentiation and apoptosis of tumor cells.[1] Vorinostat is a small molecular with the formular of C14H20N2O3 and molecular weight of 264.3. The major mechanism of HDACi-induced apoptosis is the activation of the intrinsic apoptotic pathway. HDACi can activate the intrinsic apoptotic pathway by releasing of cytochrome c from mitochondria and regulating of Bcl-2 family expression.[2]
Vorinostat（又称亚硝基苯酰氢氧酰胺）是一种组蛋白去乙酰化酶抑制剂（HDACi），在表观遗传或非表观遗传调控中发挥重要作用，可诱导肿瘤细胞生长停滞、分化和凋亡[1]。 Vorinostat是一种小分子，化学式为C14H20N2O3，分子量为264.3。 HDACi诱导凋亡的主要机制是激活内在凋亡通路。 HDACi可以通过释放线粒体中的细胞色素c和调节Bcl-2家族表达来激活内在凋亡通路[2]。
Reference
[1] Hui-ming Z, Qian-hai D, Wei-ping C, Ru-bin L. Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-kB nuclear translocation. International Immunopharmacology. 2013, 17. 329-335.
[2] Norihisa U, Sayaka K, Hisanori M, Katsuhiko Y, Airo T. Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells. Cancer Letters. 2012, 315. 112-121.