GlpBio

Mitophagy

Mitophagy(线粒体自噬)

Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Mitophagy 相关产品(83)

  • GA10942 structure
    GA10942H-D-Gln-OH
    CAS: 5959-95-5
    纯度: >99.00%

    H-D-Gln-OH 是一种可渗透细胞的 D 型谷氨酰胺立体异构体。

  • GC10200 structure
    GC10200Mdivi 1
    CAS: 338967-87-6
    纯度: >99.50% / >98.00%

    Mdivi-1（线粒体分裂抑制剂 1）抑制创伤性脑损伤 (TBI) 诱导的动力蛋白相关蛋白 1 (Drp1) 上调、自噬功能障碍和线粒体自噬激活。

  • GC10480 structure
    GC10480Betulinic acid
    CAS: 472-15-1
    纯度: >98.00%

    白桦脂酸（Betulinic acid）是一种天然的五环三萜类化合物，是真核细胞拓扑异构酶I的抑制剂，IC 50 值为5μM。

  • GC10518 structure
    GC10518AICAR
    CAS: 2627-69-2
    纯度: >98.00% / >99.00%

    AICAR（也称为 acadesine）是一种嘌呤核苷。

  • GC10580 structure
    GC10580AICAR phosphate
    CAS: 681006-28-0
    纯度: >99.00% / >98.00%

    An activator of AMPK

  • GC10585 structure
    GC10585Simvastatin (Zocor)
    CAS: 79902-63-9
    纯度: >99.00% / >98.00%

    An HMG-CoA reductase inhibitor

  • GC10710 structure
    GC107103-Methyladenine
    CAS: 5142-23-4
    纯度: >97.00% / >96.00% / >98.00%

    3-甲基腺嘌呤是一种经典的自噬抑制剂。

  • GC11237 structure
    GC11237Dexamethasone acetate
    CAS: 1177-87-3
    纯度: >98.00%

    An acetate form of dexamethasone

  • GC11332 structure
    GC11332Pitavastatin
    CAS: 147511-69-1

    Pitavastatin是一种3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂，在Hep G2细胞中对HMG-CoA还原酶活性的IC 50 值为5.8nM。

  • GC11424 structure
    GC11424Valproic acid
    CAS: 99-66-1
    纯度: >98.00%

    A class I HDAC inhibitor

  • GC11720 structure
    GC1172017-AAG (KOS953)
    CAS: 75747-14-7
    纯度: >99.00% / >98.00%

    17-AAG（格尔德霉素）是一种天然的苯醌安沙霉素抗生素，是第一个确定的 Hsp90 抑制剂。

  • GC12017 structure
    GC12017Isoniazid
    CAS: 54-85-3
    纯度: >99.50%

    An inhibitor of mycolic acid synthesis

  • GC12116 structure
    GC12116Pitavastatin Calcium
    CAS: 147526-32-7
    纯度: >99.00%

    An HMG-CoA reductase inhibitor

  • GC12339 structure
    GC12339Ivermectin
    CAS: 70288-86-7
    纯度: >98.00%

    Ivermectin是一种大环内酯类内外抗寄生虫药，对体内和体外寄生虫均有活性。

  • GC12495 structure
    GC12495Olanzapine
    CAS: 132539-06-1
    纯度: >99.00% / >98.00% / >99.50%

    Olanzapine是一种单胺拮抗剂。

  • GC13001 structure
    GC13001SB 203580 hydrochloride
    CAS: 869185-85-3
    纯度: >98.00%

    A water soluble p38 MAPK inhibitor

  • GC13443 structure
    GC13443Doxazosin Mesylate
    CAS: 77883-43-3
    纯度: >99.50%

    An α 1 -AR antagonist

  • GC13554 structure
    GC13554Deferoxamine mesylate
    CAS: 138-14-7
    纯度: >98.00% / >99.00% / >98.50% / >99.50%

    Deferoxamine mesylate 是一种通过形成稳定的复合物来螯合铁的药物，该复合物可防止铁进入进一步的化学反应，并用于治疗输血依赖性贫血患者的慢性铁过载。

  • GC13595 structure
    GC13595SB 203580
    CAS: 152121-47-6
    纯度: >98.00% / >99.00%

    SB 203580是p38-MAPK（有丝分裂原活化蛋白激酶）通路的特异性抑制剂。

  • GC14191 structure
    GC14191Ruxolitinib (INCB18424)
    CAS: 941678-49-5
    纯度: >98.00%

    Ruxolitinib (INCB18424)作为一种抑制剂，能够抑制Janus相关激酶(JAKs)JAK1和JAK2, IC50 分别为 3.3 nM 和 2.8 nM，Ruxolitinib介导对造血和免疫功能重要的若干细胞因子和生长因子信号。

  • GC14553 structure
    GC14553Resveratrol
    CAS: 501-36-0
    纯度: >99.50%

    白藜芦醇（转-白藜芦醇；SRT501）是一种植物抗菌素。

  • GC14591 structure
    GC14591Hemin chloride
    CAS: 16009-13-5
    纯度: >98.00%

    氯化血红素是血红素加氧酶(HO)-1的底物，可诱导多种细胞表达HO-1，发挥抗氧化和抗炎作用。

  • GC14683 structure
    GC14683Sunitinib malate
    CAS: 341031-54-7
    纯度: >99.00%

    A multi-kinase inhibitor

  • GC14787 structure
    GC14787Curcumin
    CAS: 458-37-7
    纯度: >98.00%

    A yellow pigment with diverse biological activities