Olanzapine is a monoamine antagonist [1]. Olanzapine inhibits 5-hydroxytryptamine 2A (5-HT2A) receptors with high affinity and antagonizes dopamine D2 receptors, thereby alleviating symptoms in patients with schizophrenia and bipolar disorder [2-3]. Olanzapine is commonly used to treat acute mania in schizophrenia and bipolar I disorder [4].
In PC12 cells, Olanzapine (100μM; 24h) pretreatment attenuated the decrease in cell viability induced by hydrogen peroxide [5]. In U87 cells, Olanzapine (0-400µM; 24-72h) inhibits tumor cell growth and induces autophagy [6].
In C57BL/6J mice, Olanzapine (6mg/kg; ig; 7 weeks) treatment increased mice food intake and body weight [7]. In Swiss–Kunming mice, Olanzapine (0.01-0.1mg/kg; sc; single injection) treatment improves spatial learning function in the Morris water maze task in mice [8].
References:
[1]. Thomas K, Saadabadi A. Olanzapine[J]. 2018.
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[3]. Taraskina A E, Nasyrova R F, Zabotina A M, et al. Potential diagnostic markers of olanzapine efficiency for acute psychosis: a focus on peripheral biogenic amines[J]. BMC psychiatry, 2017, 17(1): 394.
[4]. McCormack P L, Wiseman L R. Olanzapine: a review of its use in the management of bipolar I disorder[J]. Drugs, 2004, 64(23): 2709-2726
[5]. Wei Z, Bai O, Richardson J S, et al. Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxide[J]. Journal of neuroscience research, 2003, 73(3): 364-368.
[6]. Zhu Y, Zhao Y F, Liu R S, et al. Olanzapine induced autophagy through suppression of NF‐κB activation in human glioma cells[J]. CNS Neuroscience & Therapeutics, 2019, 25(9): 911-921.
[7]. Hou P H, Chang G R, Chen C P, et al. Long-term administration of olanzapine induces adiposity and increases hepatic fatty acid desaturation protein in female C57BL/6J mice[J]. Iranian Journal of Basic Medical Sciences, 2018, 21(5): 495.
[8]. Hou Y, Wu C F, Yang J Y, et al. Differential effects of haloperidol, clozapine and olanzapine on learning and memory functions in mice[J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006, 30(8): 1486-1495.
Olanzapine是一种单胺拮抗剂 [1]。Olanzapine以高亲和力抑制5-羟色胺2A（5-HT2A）受体，并拮抗多巴胺D2受体，从而缓解精神分裂症和双相情感障碍患者的症状 [2-3]。Olanzapine常用于治疗精神分裂症和I型双相情感障碍的急性躁狂症 [4]。
在PC12细胞中，Olanzapine（100μM；24h）预处理可减轻过氧化氢诱导的细胞活力下降 [5]。在U87细胞中，Olanzapine（0-400μM；24-72h）可抑制肿瘤细胞生长并诱导自噬 [6]。
在C57BL/6J小鼠中，Olanzapine（6mg/kg；ig；7周）治疗可增加小鼠的食物摄入量和体重 [7]。在瑞士昆明小鼠中，Olanzapine（0.01-0.1mg/kg；sc；单次注射）治疗可改善小鼠在Morris水迷宫任务中的空间学习功能 [8]。