GlpBio

Mitophagy

Mitophagy(线粒体自噬)

Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Mitophagy 相关产品(83)

  • GC14882 structure
    GC14882Salinomycin
    CAS: 53003-10-4
    纯度: >98.00%

    A selective cancer stem cell inhibitor

  • GC14968 structure
    GC14968Esmolol HCl
    CAS: 81161-17-3
    纯度: >99.00%

    A β 1 -AR antagonist

  • GC15083 structure
    GC15083Celastrol
    CAS: 34157-83-0
    纯度: >99.50%

    Celastrol是一种蛋白酶体抑制剂，有效且优先的抑制纯化的20S蛋白酶体，IC 50 为2.5 μM。

  • GC15617 structure
    GC15617Etoposide
    CAS: 33419-42-0
    纯度: >99.50% / >99.00% / >98.50%

    Etoposide（VP-16）是一种非特异性拓扑异构酶II（Topoisomerase II）抑制剂，IC 50 值为59.2 μM。

  • GC15618 structure
    GC15618Melatonin
    CAS: 73-31-4
    纯度: >99.00% / >98.50%

    An indoleamine neurohormone that entrains circadian rhythms

  • GC15706 structure
    GC15706Aspirin (Acetylsalicylic acid)
    CAS: 50-78-2
    纯度: >99.50%

    A non-selective, irreversible COX inhibitor

  • GC15794 structure
    GC15794Valproic acid sodium salt (Sodium valproate)
    CAS: 1069-66-5
    纯度: >98.00%

    Valproic acid sodium salt (Sodium valproate)（VPA）是一种具有口服活性的组蛋白脱乙酰酶 （HDAC）抑制剂，IC 50 值为1.5mM，抑制HDAC1的IC 50 值为400μM，同时可诱导HDAC2的降解。

  • GC15904 structure
    GC15904PP242
    CAS: 1092351-67-1
    纯度: >98.50%

    Potent inhibitor of mTOR kinase in both mTORC1 and mTORC2

  • GC15951 structure
    GC15951URB597
    CAS: 546141-08-6
    纯度: >99.00%

    An inhibitor of FAAH

  • GC16105 structure
    GC16105Iohexol
    CAS: 66108-95-0
    纯度: >98.00%

    Iohexol是一种低渗透压非离子型造影剂，为三碘化苯衍生物，分子量为821.1Da。

  • GC16124 structure
    GC16124Ruxolitinib phosphate
    CAS: 1092939-17-7
    纯度: >99.50%

    A potent and selective JAK1/JAK2 inhibitor

  • GC16267 structure
    GC162676-Hydroxydopamine hydrobromide
    CAS: 636-00-0
    纯度: >98.00%

    6-Hydroxydopamine hydrobromide (6-OHDA) 是儿茶酚胺、多巴胺和去甲肾上腺素的结构类似物，对儿茶酚胺能神经元发挥毒性作用。

  • GC16508 structure
    GC16508Salicylic acid
    CAS: 69-72-7
    纯度: >98.00%

    An Analytical Reference Standard

  • GC16994 structure
    GC16994Doxorubicin
    CAS: 23214-92-8
    纯度: >98.00%

    多柔比星（Doxorubicin，简称DOX），也被称为阿霉素，是一种蒽环类化合物，具有最广泛的活性谱。

  • GC17234 structure
    GC17234ABT-737
    CAS: 852808-04-9
    纯度: >98.00%

    ABT-737作为一种BH3模拟药物，是Bcl-2家族的抑制剂，可抑制Bcl2、Bcl-xL和Bcl-w的活性，IC 50 值<1nM。

  • GC17340 structure
    GC17340Carbamazepine
    CAS: 298-46-4
    纯度: >99.50%

    卡马西平是一种钠通道阻滞剂，是一种抗惊厥药。

  • GC17390 structure
    GC17390Vorinostat (SAHA, MK0683)
    CAS: 149647-78-9
    纯度: >98.00% / >99.00%

    An HDAC inhibitor

  • GC17443 structure
    GC17443Metformin HCl
    CAS: 1115-70-4
    纯度: >98.00%

    A biguanide with diverse biological activities

  • GC17567 structure
    GC17567Doxorubicin (Adriamycin) HCl
    CAS: 25316-40-9
    纯度: >99.50% / >98.00%

    An anthracycline antitumor antibiotic

  • GC17580 structure
    GC17580Olaparib (AZD2281, Ku-0059436)
    CAS: 763113-22-0
    纯度: >99.50% / >98.00%

    Olaparib (AZD2281, Ku-0059436) 是一种有效的选择性 PARP 抑制剂，特异性靶向 PARP1 和 PARP2（IC 50 分别 = 5 nM 和 1 nM）。

  • GC17651 structure
    GC17651Sunitinib
    CAS: 557795-19-4
    纯度: >99.00% / >98.00%

    舒尼替尼Sunitinib（SU 11248）是一种具口服活性的多靶点受体酪氨酸激酶抑制剂，对血管内皮生长因子受体（VEGFR2）和血小板衍生生长因子受体（PDGFRβ）的IC 50 分别为80nM和2nM。

  • GC17683 structure
    GC17683Brefeldin A
    CAS: 20350-15-6
    纯度: >99.50%

    Brefeldin A（BFA）是一种真菌大环内酯，能够有效、可逆地抑制内质网和高尔基体之间的蛋白质运输和囊泡形成。

  • GC17874 structure
    GC17874Matrine
    CAS: 519-02-8
    纯度: >98.00%

    苦参碱（Matrine）是一种存在于槐属植物中的生物碱，可作为 kappa 阿片受体和μ-受体激动剂。

  • GC18049 structure
    GC18049GSK2578215A
    CAS: 1285515-21-0
    纯度: >99.50%

    A potent LRRK2 inhibitor