Spleen Tyrosine Kinase (Syk)

An inhibitor of Src, Syk, and platelet aggregation

A prodrug of a Syk inhibitor

BAY 61-3606 dihydrochloride 是一种可口服的、ATP 竞争性、可逆和高选择性的 Syk 抑制剂，Ki 为 7.5 nM，IC50 为 10 nM。

A Syk inhibitor

A selective spleen tyrosine kinase inhibitor

R406是一种口服可用的脾酪氨酸激酶（Syk）抑制剂，IC 50 值为41nM，并以K i =30nM竞争性地抑制ATP结合。

Piceatannol(3,3 '，4,5 ' -反式三羟基二苯乙烯)是天然存在的白藜芦醇羟基化类似物。

PRT062607 Hydrochloride (P505-15 Hydrochloride) 是一种高度特异性和有效的纯化 Syk 抑制剂 (IC50 1-2 nM)。

A dual inhibitor of Syk and JAKs

A potent and selective Syk inhibitor

RO9021 是一种具有口服生物利用度的新型 ATP 竞争性 SYK 抑制剂，平均 IC50 为 5.6 nM。

A potent and selective Syk inhibitor

Fostamatinib (R788) 二钠六水合物是活性化合物 R406 的口服前药。

TAK-659 hydrochloride 是一种高效、选择性、可逆和口服的脾酪氨酸激酶 (SYK) 和 fms 相关酪氨酸激酶 3 (FLT3) 双重抑制剂，对 SYK 和 FLT3 的 IC50 分别为 3.2 nM 和 4.6 nM。 TAK-659 hydrochloride 在肿瘤细胞中诱导细胞死亡，但在非肿瘤细胞中不诱导细胞死亡，并具有治疗慢性淋巴细胞白血病 (CLL) 的潜力。

PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.

A potent, orally bioavailable Syk inhibitor

A dual inhibitor of JAKs and Syk family kinases

A Syk inhibitor

A Syk inhibitor

TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.

A Syk inhibitor

A selective blocker of spleen tyrosine kinase activity

Syk-IN-1 (compound 4) 是一种有效的 Syk 抑制剂，IC50为 35 nM。

SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.