GlpBio

IGF1R

IGF1R(胰岛素样生长因子1受体)

IGF1R (insulin-Like growth factor 1 receptor) is a receptor tyrosine kinase that bind to insulin-like growth factor 1 with high affinity. It plays a vital role in in cell growth, cell survival and malignant transformation etc.

IGF1R 相关产品(34)

  • GC13697 structure
    GC13697AG-1024
    CAS: 65678-07-1
    纯度: >98.50%

    AG-1024是一种可逆的，竞争性和选择性的胰岛素样生长因子-1受体（IGF-1R）抑制剂，IC 50 值为7μM。AG-1024能够抑制胰岛素受体（IR）的磷酸化，IC 50 值为57μM。

  • GC16991 structure
    GC16991PQ 401
    CAS: 196868-63-0
    纯度: >99.50%

    An inhibitor of IGF-1R

  • GC12273 structure
    GC12273GSK1838705A
    CAS: 1116235-97-2
    纯度: >99.00%

    GSK1838705A是一种小分子激酶抑制剂，可靶向胰岛素样生长因子1受体（IGF-1R）和胰岛素受体，其IC₅₀分别为2.0nM和1.6nM。

  • GC12712 structure
    GC12712NT157
    CAS: 1384426-12-3

    NT157是一种具有选择性的胰岛素受体底物-1/-2（IRS-1/2）抑制剂。

  • GC12963 structure
    GC12963NVP-AEW541
    CAS: 475489-16-8
    纯度: >98.50%

    An IGF-1R inhibitor

  • GC13102 structure
    GC13102XL228
    CAS: 898280-07-4
    纯度: >99.00%

    A tyrosine kinase inhibitor

  • GC14189 structure
    GC14189AZD-3463
    CAS: 1356962-20-3
    纯度: >99.50%

    An ALK and IGF-1R inhibitor

  • GC14552 structure
    GC14552LDK378
    CAS: 1032900-25-6
    纯度: >99.50%

    An ALK inhibitor

  • GC15749 structure
    GC15749Linsitinib
    CAS: 867160-71-2
    纯度: >98.00%

    Linsitinib是一种强效、选择性、具有口服生物利用度的IGF-1R/IR双激酶抑制剂，对IGF-1R和IR的IC 50 值分别为0.035μM和0.075μM。

  • GC16712 structure
    GC16712BMS-754807
    CAS: 1001350-96-4
    纯度: >99.50% / >98.00%

    Dual inhibitor of IGF-1R and InsR tyrosine kinases

  • GC16821 structure
    GC16821TAE226(NVP-TAE226)
    CAS: 761437-28-9
    纯度: >98.00%

    TAE226(NVP-TAE226)是一种强效的ATP竞争性抑制剂，能抑制多种酪氨酸蛋白激酶，尤其是FAK和IGF-IR激酶，其IC 50 值分别为5.5nM和140nM。

  • GC17452 structure
    GC17452LDK378 dihydrochloride
    CAS: 1380575-43-8
    纯度: >99.50%

    LDK378 dihydrochloride (LDK378 dihydrochloride) 是一种选择性、口服生物利用度和 ATP 竞争性的 ALK 酪氨酸激酶抑制剂，IC50 为 200 pM。

  • GC17612 structure
    GC17612GSK1904529A
    CAS: 1089283-49-7
    纯度: >99.00%

    A dual inhibitor of InsR and IGF-1R kinases

  • GC17773 structure
    GC17773BMS-536924
    CAS: 468740-43-4
    纯度: >98.50%

    A dual inhibitor of IGF-1R and IR

  • GC25881 structure
    GC25881S961
    CAS: 1083433-49-1

    S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.

  • GC31706 structure
    GC31706Ginsenoside Rg5
    CAS: 186763-78-0
    纯度: >98.00%

    A ginsenoside with diverse biological activities

  • GC33072 structure
    GC33072AZ7550
    CAS: 1421373-99-0

    An active metabolite of AZ 9291

  • GC34287 structure
    GC34287AZ7550 hydrochloride
    CAS: 2309762-40-9

    An active metabolite of AZ 9291

  • GC34414 structure
    GC34414AZ7550 Mesylate (AZ7550 trimesylate salt)

    An active metabolite of AZ 9291

  • GC36311 structure
    GC36311Indirubin Derivative E804
    CAS: 854171-35-0
    纯度: >99.50%

    Indirubin Derivative E804, 是类胰岛素生长因子1型受体 (IGF1R) 的有效抑制剂，其 IC50 值为 0.65 μM。

  • GC44474 structure
    GC44474NVP-AEW541 (hydrochloride)
    CAS: 2320261-63-8
    纯度: >98.00%

    An IGF-1R inhibitor

  • GC45789 structure
    GC45789Ceritinib-d7
    CAS: 1632484-77-5
    纯度: >99.00%

    An internal standard for the quantification of ceritinib

  • GC61111 structure
    GC61111NBI-31772 hydrate
    纯度: >98.00%

    A nonpeptide ligand that releases IGF-1 from IGFBP

  • GC63297 structure
    GC63297I-OMe-Tyrphostin AG 538
    CAS: 1094048-77-7
    纯度: >99.00%

    I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) 是 IGF-1R 激酶的特异性抑制剂。I-OMe-Tyrphostin AG 538 抑制 IGF-1R 介导的信号传导，并优先对营养缺乏的 PANC1 细胞产生细胞毒性。I-OMe-Tyrphostin AG 538 是具有 ATP 竞争性的 PI5P4Kα抑制剂，IC50 为 1 μM。