Fangchinoline is an alkaloid that has been found in S. tetrandrae and has diverse biological activities, including anti-inflammatory, neuroprotective, and anticancer properties.1,2,3 It inhibits the activity of sheep COX and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells with IC50 values of 129 and 3.7 ?M, respectively.1 Fangchinoline (1 and 10 ?M) reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons.2 It decreases proliferation of PC3 human prostate cancer cells by 63 and 86% when used at concentrations of 20 and 30 ?M, respectively.3 Fangchinoline reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 5 mg/kg per day for 12 days.
1.Choi, H.S., Kim, H.S., Min, K.R., et al.Anti-inflammatory effects of fangchinoline and tetrandrineJ. Ethnopharmacol.69(2)173-179(2000) 2.Cho, S.O., and Seong, Y.H.Protective effect of fangchinoline on cyanide-induced neurotoxicity in cultured rat cerebellar granule cellsArch. Pharm. Res.25(3)349-356(2002) 3.Wang, C.D., Huang, J.G., Gao, X., et al.Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograftBiosci. Biotechnol. Biochem.74(3)488-493(2010)