GlpBio

Entecavir Hydrate3X 积分

目录号: GC16092纯度: >99.50%同义词: 恩替卡韦 (1水合物); BMS200475 monohydrate; SQ34676 monohydrate
An antiviral nucleoside analog
Entecavir Hydrate
Cas No.: 209216-23-9
规格价格库存数量操作
1mg¥207.00现货
1
5mg¥455.00现货
1
10mg¥553.00现货
1
50mg¥1,448.00现货
1
100mg¥2,100.00现货
1
200mg¥3,360.00现货
1
10mM (in 1mL DMSO)¥501.00现货
1
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文献被引

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产品描述 Description

Entecavir hydrate is a reverse transcriptase inhibitor.
Reverse transcriptase (RT) is used to generate complementary DNA (cDNA) from an RNA template, which is mainly associated with retroviruses, such as HBV.
Entecavir hydrate is an oral antiviral drug used in the treatment of hepatitis B virus (HBV) infection. In 17 patients with hepatitis B virus (HBV) genotype C, treatment with peginterferon
(PEG-IFN) a-2b combination with entecavir hydrate (ETV) for 48 weeks. Among 11 patients exhibited pretherapy HBeAg, 8 showed HBeAg seroconversion. Serum HBV DNA levels reduced by 5.2 and 3.3 log copies/ml by the end of the therapy and follow-up periods, respectively. Intrahepatic cccDNA reduced to 1.4 log copies/mg.  
References:
[1]. Hagiwara S, Kudo M, Osaki Y, et al. Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B. J Med Virol, 2013, 85(6): 987-995.

实验参考方法 Experimental Reference Method

Cell experiment:

BMS 200475 is prepared in phosphate-buffered saline (PBS) and diluted with appropriate medium containing 2% fetal bovine serum. HepG2 2.2.15 cells are plated at a density of 5×105 cells per well on 12-well Biocoat collagen-coated plates and are maintained in a confluent state for 2 to 3 days before being overlaid with 1 mL of medium spiked with BMS 200475. Quantification of HBV was performed on day 10[1].

References:

[1]. Innaimo SF, et al. Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus. Antimicrob Agents Chemother. 1997 Jul;41(7):1444-8.
[2]. Rivkin A, et al. A review of entecavir in the treatment of chronic hepatitis B infection. Curr Med Res Opin. 2005 Nov;21(11):1845-56.
[3]. Genovesi EV, et al. Efficacy of the carbocyclic 2'-deoxyguanosine nucleoside BMS-200475 in the woodchuck model of hepatitis B virus infection. Antimicrob Agents Chemother. 1998 Dec;42(12):3209-17.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
209216-23-9
同义词
恩替卡韦 (1水合物); BMS200475 monohydrate; SQ34676 monohydrate
化学名
2-amino-9-[(3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one;hydrate
SMILES
C=C1C(CC(C1CO)O)N2C=NC3=C2NC(=NC3=O)N.O
分子式
C12H15N5O3.H2O
分子量
295.29 g/mol
溶解性
≥ 9.7mg/mL in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol