GlpBio

Discoidin Domain Receptor

Discoidin Domain Receptor(盘状结构域受体)

Discoidin domain receptors (DDRs) are receptor tyrosine kinases with the unique ability among receptor tyrosine kinases to respond to collagen. Several signaling molecules have been implicated in DDR signaling, including Shp-2, Src, and MAPK pathways. DDRs have been reported to induce the expression of various genes including matrix metalloproteinases and bone morphogenetic proteins, but the regulatory mechanisms underlying DDR-induced gene expression remain to be determined. DDRs regulate cell-collagen interactions in normal and pathological conditions and thus are emerging as major sensors of collagen matrices and potential novel therapeutic targets.

Discoidin Domain Receptor 相关产品(16)

  • GC11057 structure
    GC11057LY2801653
    CAS: 1206799-15-6
    纯度: >98.00%

    A MET kinase inhibitor

  • GC17365 structure
    GC17365DDR1-IN-1
    CAS: 1449685-96-4
    纯度: >98.00%

    A selective discoidin domain receptor 1 inhibitor

  • GC19332 structure
    GC19332Sitravatinib
    CAS: 1123837-84-2
    纯度: >99.50%

    Sitravatinib是一种酪氨酸激酶抑制剂（TKI），能够作用于TYRO3、AX和MERTK（TAM）受体、血管内皮生长因子受体（VEGFR）家族、c-Kit 和 c-MET。

  • GC31724 structure
    GC31724DDR1-IN-2
    CAS: 1429617-90-2
    纯度: >99.00%

    DDR1-IN-2是一种盘状结构域受体1(DDR1)的有效抑制剂，IC 50 为13.1nM，对DDR2的抑制效果相对较弱，IC 50 为203nM。

  • GC33297 structure
    GC33297DDR1-IN-3
    CAS: 1934246-19-1

    DDR1-IN-3 是一种选择性 Discoidin Domain Receptor 1 (DDR1) 抑制剂，IC50 值为 9.4 nM。 DDR1-IN-3 也抑制 TRK 家族。

  • GC33361 structure
    GC33361DDR Inhibitor
    CAS: 1644069-80-6
    纯度: >99.00%

    DDRInhibitor是一种高效的盘状结构域受体(discoidindomainreceptor)抑制剂，对DDR2的IC50值为3.3nM，在浓度为1.5nM时，对DDR1有53%的抑制作用。

  • GC35822 structure
    GC35822DDR1-IN-1 dihydrochloride
    CAS: 1780303-76-5

    DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2.

  • GC36585 structure
    GC36585Merestinib dihydrochloride
    CAS: 1206801-37-7
    纯度: >98.00%

    Merestinib dihydrochloride (LY2801653 dihydrochloride) 是一种II型ATP竞争性的 MET 抑制剂，Ki 值为 2 nM。

  • GC38206 structure
    GC38206WRG-28
    CAS: 1913291-02-7
    纯度: >99.00%

    WRG-28 是选择性，细胞外作用的 DDR2 变构抑制剂，IC50 为 230 nM。WRG-28 通过受体的变构调节特异地抑制受体-配体相互作用。WRG-28 通过靶向 DDR2 抑制肿瘤侵袭和迁移，基质的肿瘤支持作用，并抑制肺中的转移性乳腺肿瘤细胞定植。

  • GC39301 structure
    GC39301VU6015929
    CAS: 2442597-56-8
    纯度: >98.00%

    VU6015929 is a selective Discoidin Domain Receptor 1/2 (DDR1/2) inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively. VU6015929 potently inhibits collagen-IV production.

  • GC64268 structure
    GC64268DDR1-IN-4
    CAS: 2125676-13-1

    DDR1-IN-4 (Compound 2.45) 是有效、选择性的盘肽结构域受体 1 (DDR1) 自磷酸化的抑制剂，其对 DDR1 和 DDR2 的IC50 值分别为 29 nM 和 1.9 μM。

  • GC65212 structure
    GC65212FGFR1/DDR2 inhibitor 1
    CAS: 2308497-58-5
    纯度: >99.00%

    FGFR1/DDR2 inhibitor 1 is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoidin domain receptor 2 (DDR2).

  • GC65378 structure
    GC65378DDR1-IN-5
    CAS: 2416022-90-5

    DDR1-IN-5 是选择性的盘状结构域受体家族成员 1 (DDR1) 抑制剂，IC50 为 7.36 nM。DDR1-IN-5 抑制 DDR1b (Y513) 自磷酸化，IC50 为 4.1 nM。DDR1-IN-5 具有抗癌活性。

  • GC66476 structure
    GC66476DDR1-IN-6
    CAS: 2416021-47-9

    DDR1-IN-6 是选择性的盘状结构域受体家族成员 1 (DDR1) 抑制剂，IC50 为 9.72 nM。DDR1-IN-6 抑制 DDR1b (Y513) 自磷酸化，IC50 为 9.7 nM。DDR1-IN-6 具有抗癌活性。

  • GC70345 structure
    GC70345DDR2-IN-1
    CAS: 1573053-23-2
    纯度: >99.00%

    DDR2-IN-1是有效的DDR2抑制剂，IC50为26nM。

  • GC73659 structure
    GC73659DDR1/2 inhibitor-2
    CAS: 2908756-11-4
    纯度: >99.00%

    DDR1/2 inhibitor-2（实施例31）是一种DDR1/DDR2抑制剂，IC50值小于100nM。