GlpBio

ALK

ALK (anaplastic lymphoma kinase) is a member of insulin receptor protein-tyrosine superfamily, functioning in embryonic development and involved in cell survival and cell fate.

ALK 相关产品(61)

  • GC14189 structure
    GC14189AZD-3463
    CAS: 1356962-20-3
    纯度: >99.50%

    An ALK and IGF-1R inhibitor

  • GC14552 structure
    GC14552LDK378
    CAS: 1032900-25-6
    纯度: >99.50%

    An ALK inhibitor

  • GC14729 structure
    GC14729(R)-Crizotinib
    CAS: 877399-52-5
    纯度: >99.50%

    A c-MET and ALK receptor tyrosine kinase inhibitor

  • GC17035 structure
    GC17035LDN-212854
    CAS: 1432597-26-6
    纯度: >98.00%

    An ALK2 inhibitor

  • GC17452 structure
    GC17452LDK378 dihydrochloride
    CAS: 1380575-43-8
    纯度: >99.50%

    LDK378 dihydrochloride (LDK378 dihydrochloride) 是一种选择性、口服生物利用度和 ATP 竞争性的 ALK 酪氨酸激酶抑制剂，IC50 为 200 pM。

  • GC17582 structure
    GC17582ML347
    CAS: 1062368-49-3
    纯度: >98.00%

    A selective ALK1 and ALK2 inhibitor

  • GC12273 structure
    GC12273GSK1838705A
    CAS: 1116235-97-2
    纯度: >99.00%

    GSK1838705A是一种小分子激酶抑制剂，可靶向胰岛素样生长因子1受体（IGF-1R）和胰岛素受体，其IC₅₀分别为2.0nM和1.6nM。

  • GC13136 structure
    GC13136(S)-Crizotinib
    CAS: 1374356-45-2
    纯度: >99.50%

    An MTH1 inhibitor

  • GC13225 structure
    GC13225LDN-214117
    CAS: 1627503-67-6
    纯度: >99.50%

    A selective ALK1 and ALK2 inhibitor

  • GC13902 structure
    GC13902KRCA 0008
    CAS: 1472795-20-2
    纯度: >98.50%

    KRCA 0008 是一种选择性 ALK/Ack1 抑制剂，对 ALK 和 Ack1 的 IC50 分别为 12 和 4 nM。 KRCA 0008 可用于癌症研究。

  • GC14349 structure
    GC14349SB525334
    CAS: 356559-20-1
    纯度: >99.50% / >98.00%

    SB525334已被鉴定为一种高效且选择性的转化生长因子β1（TGF-β1）受体、活化素受体样激酶（ALK5）抑制剂。SB525334对ALK5激酶活性的IC 50 为14.3nM。

  • GC14446 structure
    GC14446ASP3026
    CAS: 1097917-15-1
    纯度: >99.50%

    An ALK inhibitor

  • GC14476 structure
    GC14476Entrectinib
    CAS: 1108743-60-7
    纯度: >99.00%

    Entrectinib是一种具有口服活性、可穿透血脑屏障（BBB）且在中枢神经系统起作用的TrkA/B/C、ROS1与ALK抑制剂，其IC 50 值分别为1、3、5、12和7nM。

  • GC14794 structure
    GC14794PF-06463922
    CAS: 1454846-35-5
    纯度: >99.50%

    PF-06463922是一种新型的、具有口服活性的ALK（IC 50 =15-113nM）和ROS1（K i s=0.025-0.7nM）双重抑制剂。

  • GC14931 structure
    GC14931LDN193189 Hydrochloride
    CAS: 1062368-62-0
    纯度: >98.50%

    LDN193189 (hydrochloride) 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。

  • GC15145 structure
    GC15145CEP-28122
    CAS: 1022958-60-6

    An orally active ALK inhibitor

  • GC15273 structure
    GC15273CEP-37440
    CAS: 1391712-60-9
    纯度: >99.50%

    A dual inhibitor of FAK1 and ALK

  • GC16025 structure
    GC16025CH5424802
    CAS: 1256580-46-7
    纯度: >99.50%

    An orally available inhibitor of ALK

  • GC16580 structure
    GC16580LDN-193189
    CAS: 1062368-24-4
    纯度: >99.00%

    An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6

  • GC16694 structure
    GC16694TAE684 (NVP-TAE684)
    CAS: 761439-42-3
    纯度: >99.00%

    A selective ALK inhibitor

  • GC17283 structure
    GC17283AP26113
    CAS: 1197958-12-5
    纯度: >99.50%

    A potent ALK inhibitor

  • GC17376 structure
    GC17376ALK inhibitor 2
    CAS: 761438-38-4
    纯度: >99.50%

    An inhibitor of TSSK2

  • GC19063 structure
    GC19063Belizatinib
    CAS: 1357920-84-3
    纯度: >97.00%

    An ALK inhibitor

  • GC19084 structure
    GC19084Brigatinib
    CAS: 1197953-54-0
    纯度: >99.50%

    An orally bioavailable ALK inhibitor