ALK

ALK (anaplastic lymphoma kinase) is a member of insulin receptor protein-tyrosine superfamily, functioning in embryonic development and involved in cell survival and cell fate.

Products for ALK

Cat.No. 产品名称 Information
GC12273 GSK1838705A GSK1838705A是一种小分子激酶抑制剂，可靶向胰岛素样生长因子1受体（IGF-1R）和胰岛素受体，其IC₅₀分别为2.0nM和1.6nM。
GC14552 LDK378
色瑞替尼; LDK378
An ALK inhibitor
GC16580 LDN-193189
LDN 193189;LDN193189

An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
GC17283 AP26113
Brigatinib analog
A potent ALK inhibitor
GC14349 SB525334
6-[2-(1,1-二甲基乙基)-5-(6-甲基-2-吡啶基)-1H-咪唑-4-基]喹喔啉
SB525334已被鉴定为一种高效且选择性的转化生长因子β1（TGF-β1）受体、活化素受体样激酶（ALK5）抑制剂。SB525334对ALK5激酶活性的IC₅₀为14.3nM。
GC16694 TAE684 (NVP-TAE684)
TAE 684
A selective ALK inhibitor
GC14931 LDN193189 Hydrochloride
DM-3189 hydrochloride

LDN193189 (hydrochloride) 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。
GC17452 LDK378 dihydrochloride
双盐酸盐色瑞替尼; LDK378 dihydrochloride
LDK378 dihydrochloride (LDK378 dihydrochloride) 是一种选择性、口服生物利用度和 ATP 竞争性的 ALK 酪氨酸激酶抑制剂，IC50 为 200 pM。
GC14446 ASP3026
ASP 3026;ASP-3026
An ALK inhibitor
GC17376 ALK inhibitor 2
2-[[5-氯-2-[[2-甲氧基-4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]-N-甲基苯磺酰胺
An inhibitor of TSSK2
GC14729 (R)-Crizotinib
克唑替尼; PF-02341066
A c-MET and ALK receptor tyrosine kinase inhibitor